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Due to the issues in the cascade, hemophilic patients don't form this clot as easily, which results in their bleeding

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Due to issues in the coagulation cascade, hemophilic patients may not activate this.

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Bruising, joint inflammation, bleeding in the brain

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- Capriotti, T., & Frizzell, J.P. (2016). Pathophysiology introductory concepts and clinical perspectives. Philadelphia, PA: F.A. Davis Company.
- Osmosis. (2017, February 7). Hemophilia - causes, symptoms, diagnosis, treatment, pathology. Retrieved from https://www.youtube.com/watch?v=nkC1vZaUpxs

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Hemophilia B is the deficiency of factor IX! Issues start here

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Hemophilia A is the deficiency of factor VII - issues start here!

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conversion of fibronogen to fibrin

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Cascade of activating factors until factor X is reached 

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Cascade of activating factors until factor X is reached 

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i.e. inflammation or atherosclerosis

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conversion of prothrombin to thrombin

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Factor X and cofactor factor V

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Factor IX and factor X

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Combine to form TF- factor VII

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Factor VII activated and connects with tissue factor

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Blood coagulation and clot formation!

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Without the clotting cascade of the factors, fibrinogen cannot convert to fibrin

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Takes LOTS of time

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Decreased ability or decreased number

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Goes in a cascade as one being cleaved activates the others being cleaved

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Formation of platelet plug

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Limits the blood flow

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Decreased clotting ability

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Deficiency of factor IX
Christmas Disease

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Deficiency of factor VIII
AKA Classic