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"I was trying to show how unfair it is to be opposed to somebody just because he's different than you are.
It was  really a preachment against bigotry"
-Stan Lee in "X-Men Allegory"

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“And from deformed [parents] deformed [offspring] comes to be,” he wrote, “just as lame come to be from lame and blind from blind, and in general they resemble often the features that are against nature, and have inborn signs such as growths and scars.
-Siddhartha Mukherjee in "The Gene: An Intimate History"

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In the biological sense, the X-Men take the hereditary mutation path, where people are born with genetic mutations and the kids of mutans are prone to be born mutants as well

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https://www.youtube.com/watch?v=Y69DPdT9X2k

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Science behind the X-Men is just as important as the way it portrays social injustice and racial problems.

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Their society, just like ours, fear the different because that is something that upsets the status-quo, the balance in an enviroment

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The genetic mutations of the X-Men and women are something born with.