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Uncontrolled cell growth originating in the breast tissue that forms a tumor that is commonly seen on x-ray, mammogram, or felt my the individual or their partner.

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Uncontrolled cell growth originating in the breast tissue that forms a tumor that is commonly seen on x-ray, mammogram, or felt my the individual or their partner.

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Not all lumps felt in the breast are cancerous however, they do increase the risk of developing cancer.

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Not all lumps felt in the breast are cancerous however, they do increase the risk of developing cancer.

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Outcomes vary depending on what stage the cancer is and depending if it has spread or not.

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Outcomes vary depending on what stage the cancer is and depending if it has spread or not.

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-TNM
Stage 0-4

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Division of cancer prevention and control. (2020). Breast Cancer. Centers for disease control and prevention. Retrieved from: https://www.cdc.gov/cancer/breast/statistics/index.htm

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Division of cancer prevention and control. (2020). Breast Cancer. Centers for disease control and prevention. Retrieved from: https://www.cdc.gov/cancer/breast/statistics/index.htm

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A multifactorial condition is one that there is a presence of a mutated gene, and in order for the mutation to be expressed, there also may have to be the presence of an environmental or lifestyle factor such as smoking, environmental toxins, diet, or ageing, or there has to be enough of the mutated gene to express the condition.

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A multifactorial condition is one that there is a presence of a mutated gene, and in order for the mutation to be expressed, there also may have to be the presence of an environmental or lifestyle factor such as smoking, environmental toxins, diet, or ageing, or there has to be enough of the mutated gene to express the condition.

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Gender
Age
Race
Family History
Reproductive/Hormonal History
Previous Breast cancer History
Dense breast tissue
Lack of physical activity
Alcohol Consumption
Obesity of overweight
Hormone replacement therapy

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Risk Factors that we can control and cannot.

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-Hereditary Breast and Ovarion Cancer syndrome (BRCA 1 + 2)

-ATM- related Breast Cancer

-Hereditary Diffuse Gastric Cancer (CDH1)

-CHEK2- related Breast Cancer

-NBM- related Breast Cancer

-Neurofibromatosis, type 1 (NF1)

-PALB2- related Breast Cancer

-PTEN Hamartoma Tumor syndrome (PTEN)/ Cowden Syndrome

-Peutz-Jeghers syndrome (STK11)

-Li-Fraumeninsyndrome (TP53)
-HER2

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Genes that influence the development of breast cancer

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Survival rates have improved markedly in the last 10 years. We now can give a percentage of likelihood that an individual will beat breast cancer depending on the stage from the SEER database.

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Localized cancer has a 99% chance of survival.

Regional cancer has an 86% chance of survival.

Distant cancer has a 27% chance of survival.

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Triple-negative breast cancer (TNBC) lack estrogen, progesterone and HER2 receptors.

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Triple-negative breast cancer (TNBC) lack estrogen, progesterone and HER2 receptors.

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Localized cancer has a 91% chance of survival.

Regional cancer has a 65% chance of survival.

Distant cancer has a 11% chance of survival.

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Localized statistics are not available because of how quickly it spreads and usually by the time you notice the inflammatory symptoms it has spread to nearby lymph.

Regional survival rates is 52%.

Distant survival rates is 18%.

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Imaging Studies-
MRI (magnetic resonance imaging)
Breast Ultrasound
Mammogram
Biopsy
Self Breast Exam- watch video below to learn proper ways and time to complete SBE.
https://www.nationalbreastcancer.org/breast-self-exam

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-Breast-Conserving Surgery (BCS)
-Mastectomy with sentinel lymph node biopsy (SLNB).
-Hormone therapy

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-emergence of the CDK 4/6 inhibitors for metastatic cancer.

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Estrogen Receptor (ER)-Positive Breast Cancer  

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-BCS- lumpectomy, partial mastectomy
-Mastectomy
-Radiation therapy
-Hormone therapy
-Chemotherapy

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-Surgery: lumpectomy, partial mastectomy, mastectomy.
-Radiation
- Chemotherapy, Hormone Therapy, HER2 Targeted drugs
-Systemic Therapy

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-Chemotherapy
-Surgery: BCS, mastectomy
-Radiation therapy

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Breast cancer diagnosis rates per 100,000 women.
-Caucasions- 125.8
-African Americans: 121.3
-Asian/Pacific Islanders: 97.7
-Hispanics: 94.5
-American Indian/Alaska Natives: 69.2

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-1 in 5 women have this enzyme on the surface of their cancer cells that promote rapid growth.
-Monoclonal Antibodies
-Antibody-Drug Conjugate (ADC)
-Kinase Inhibitors

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-Targeted Therapy
-Immunotherapy

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-Herceptin
-Neoadjuvant therapy (therapy delivered before surgery)
-drug-antibody conjugates: ado-trastuzumab emtansine (T-DM1)

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-Immunotherapy
-PARP Inhibitors
-Selected Androgen Receptor modulators (SARMs)