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Aminoglycoside Antibiotics
Antibiotics for Treatment of Tuberculosis

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streptomycin

Drug Summary

Classes

Boxed Warning

DEA Class

Description

How Supplied

Dosage & Indications

Maximum Dosage

Adults

Aminoglycoside dosing is highly variable and dependent on several factors. Doses of up to 4 g/day IM have been used. The FDA lists the maximum recommended therapeutic dose as 20 mg/kg/day; see 'Therapeutic Drug Monitoring'.

Elderly

Aminoglycoside dosing is highly variable and dependent on several factors. Doses of up to 4 g/day IM have been used. The FDA lists the maximum recommended therapeutic dose as 20 mg/kg/day; see 'Therapeutic Drug Monitoring'.

Adolescents

Aminoglycoside dosing is highly variable and dependent on several factors. Doses of up to 4 g/day IM have been used. The FDA lists the maximum recommended therapeutic dose as 20 mg/kg/day;

anaphylactoid reactions / Rapid / 0-1.0
arachnoiditis / Early / Incidence not known
hearing loss / Delayed / Incidence not known
hyposthenuria / Delayed / Incidence not known
renal tubular acidosis (RTA) / Delayed / Incidence not known
renal tubular necrosis / Delayed / Incidence not known
proteinuria / Delayed / Incidence not known
azotemia / Delayed / Incidence not known
acute generalized exanthematous pustulosis (AGEP) / Delayed / Incidence not known
exfoliative dermatitis / Delayed / Incidence not known
pancytopenia / Delayed / Incidence not known
hemolytic anemia / Delayed / Incidence not known
angioedema / Rapid / Incidence not known

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https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0012218/?report=details#warning
Warnings

This medicine may cause hearing loss. Call your doctor right away if you notice any changes in your hearing or if you have headaches, nausea, vomiting, or dizziness.

Your doctor may want to test your hearing regularly while you are taking streptomycin. Tell your doctor if you already have hearing problems before you are given this medicine.

Make sure your doctor knows if you have kidney disease or myasthenia gravis.

If you are breastfeeding, talk to your doctor before taking this medicine.

Tell your doctor if you are pregnant or become pregnant while being treated with this medicine. Streptomycin taken during a pregnancy may cause hearing problems in an unborn baby.

If your infection does not improve or if it gets worse while taking this medicine, call your doctor.
This medicine may contain a sulfite. Make sure your doctor knows if you are allergic to sulfites or have asthma.

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https://davisplus.fadavis.com/3976/meddeck/pdf/streptomycin.pdf