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Facts and research about Covid-19 Vaccinations 

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Facts and research about Covid-19 Vaccinations 

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COVID vaccines and safety: what the research says

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It is clear that coronavirus vaccines are safe and effective, but as more are rolled out, researchers are learning about the extent and nature of side effects. It is clear that coronavirus vaccines are safe and effective, but as more are rolled out, researchers are learning about the extent and nature of side effects.

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Testimonies from POC who believe they may be "Guinea Pigs" for Vaccination trials

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Testimonies from POC who believe they may be "Guinea Pigs" for Vaccination trials

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"'Are we going to be guinea pigs for the vaccine?'"

For months, Dr. James Hildreth's sister had been asking questions like this.

While public health officials were urging Americans to take measures to help stop the coronavirus, high rates of infection within Black communities fueled his sister's mistrust, said Hildreth, the president of Meharry Medical College, an historically Black institution in Nashville. She had no desire to be vaccinated, and thought officials wanted people like her - Black people - "to prove the vaccine is safe so others will take it."

Those concerns have been echoing from communities across the U.S., according to Hildreth, a member of the Biden administration's COVID-19 Health Equity Task Force. He also has worked as a Food and Drug Administration adviser on the veting of the COVID-19 vaccines' safety and effectiveness for their emergency use authorization. He knows whose lives are at stake if he doesn't take these roles seriously.

The coronavirus pandemic repeats a truth that communities of color in the United States have been saying for generations: They suffer worse health outcomes compared to white communities, and systemic racism drives those disparities.

At each turn during America's COVID-19 response, Black, Latino and Indigenous people have endured higher rates of infection, lack of access to and insurance coverage for testing and treatment and death. Despite greater vulnerability to the virus, disproportionately fewer people of color have been vaccinated across the U.S. compared to white people as the nation's immunization campaign ramps up.

Memories of historical atrocities run long and suspicions high when it comes to medical care. Black Americans are more likely than white Americans to say they do not trust their health care provider, rooted in both contemporary experiences - like that of Dr. Susan Moore, a Black physician who died of COVID-19 after posting on social media that her pain and calls for help were not taken seriously - and other painfully recent history.

From 1932 to 1972, federal researchers examined the effects of syphilis on Black men when left untreated. None of the 623 participants in the United States Public Health Service Syphilis Study were told what was happening, and, in one of the worst examples of unethical medical research in modern U.S. history, researchers secured no one's consent. They were told they had "bad blood," but researchers withheld actual treatment from them, even after penicillin was discovered as an effective, affordable and readily available therapy for the disease.

Freddie Lee Tyson was one of the men in the study. A carpenter, loving husband and father of nine children in Tuskegee, Alabama, Tyson worked throughout his adult life to build a better world for himself and his family. Tyson served as a deacon in his church and a firefighter. With his hands, he built his children's Catholic school and the barracks at present-day Moton Field Municipal Airport, where the Tuskegee Airmen excelled as the first Black pilots in the U.S. military during World War II and became national heroes.

But with all of his accomplishments, he didn't deserve to be "treated as though he didn't have any worth," said his daughter, Joyce Christian.

He was never told him he had contracted congenital syphilis from his mother or that he was enrolled in the study, and since he never developed symptoms, he wouldn't have guessed it either. When the Associated Press leaked reports that the men had been denied needed medical care for decades, one of Tyson's sons, who was enlisted in the Air Force, called his family with the news. Researchers ended the study, and later a phone call came for Tyson confirming he had been a test subject. Shortly thereafter, he independently found his name on a list of participants. Tyson's family was first shocked and then angry - "all the things you have when you find out a loved one has been in a study so inhumane," said Christian, 72, a retired nurse who told her family's story to the PBS NewsHour.

Christian said that after a few days, her father had advice for one of her sisters: "'I can't do anything about it now, but you can. You all can do something about it and never let this happen again to anyone."

"Targets for bad experiments"

Growing up, Alanna Nichols was warned about the hazards of the U.S. health care system for Black patients. Nichols' mother, a nurse for more than two decades in Ohio, told her about the horrors in Tuskegee, and that Black mothers and newborns suffered worse outcomes during childbirth than white mothers and infants. Be careful about taking new prescription drugs, her mother would caution.

"Underrepresented groups are always targets for bad experiments," said Nichols, 44, an entrepreneur and social worker by training, who added she keeps up with new peer-reviewed research on health

When the coronavirus emerged, her family - including her husband, a military veteran and U.S. Postal Service worker who has been in remission from prostate cancer - took health precautions seriously and began to avoid travel. Nichols said she obsessively washed her hands and wore face masks.

In December, the Food and Drug Administration began authorizing vaccines to prevent COVID-19 infections for emergency use, the first time the agency had done so to stop a viral pandemic.

"Underrepresented groups are always targets for bad experiments."

The only people Nichols knows personally who have gotten vaccinated are teachers at her son's school, but she said her husband will be "first in line" when it's his turn to get vaccinated.

Nichols, though, still has too many questions about the vaccine candidates. What group saw the weakest results? What are the side effects? Everything about the pandemic remains "so new and confusing," Nichols said, who craves more transparency about what is happening.

"It makes you a little paranoid to jump so fast without knowing the actual [vaccine] data points that's driving urgency," she said. The only trusted messenger she said she would believe is a retired health care professional "who don't have skin in the game" and who "understand what the paranoia or needs are as it relates to underrepresented communities."

"I need them in the conversation right now," she said.

"It made me not trust white people"

After the birth of her first child, Gabriela Momen endured dark feelings she eventually realized were symptoms of postpartum depression. A married Mexican-American mother of five in Round Rock, Texas, Momen raised concerns about her welfare during a check-up. But "My doctor just dismissed them" and chalked everything up to the "stress of being a homemaker and just my culture," she said. Momen never received mental health care, and it had another lasting effect.

"It made me not trust white people to be in charge of my well-being," she said.

Nearly a decade later, the coronavirus pandemic and calls for racial justice following the death of George Floyd opened Momen's eyes to other forms of insidious, casual racism. In her predominantly white neighborhood, Momen, 34,says it wouldn't matter if her family drove better cars or had more money to throw around than their neighbors. They would always be viewed as different because of the color of their skin, their religious beliefs as Muslims and their last name (her husband is Palestinian American).

Momen said she feels "like the vaccine was not created for us," and resents calls from public officials to get vaccinated for COVID-19.

"It makes it feel like rich, white men made a vaccine that worked for them and now we're going to have to take it to protect them," Momen said as she nursed her 1-year-old child, the sound of her four older children participating in virtual classes humming in the background.

A self-described middle-class supporter of "Medicare for All," Momen said she feels like national calls for more expansive health care coverage are ignored, "but when they have a vaccine, they shove it down our throats."

Even if her family decides to eventually get the vaccine, she is discouraged by the current lack of shots near her home in suburban Austin. Members of her household (who include her in-laws) are also concerned about data that suggest some vaccines may be somewhat less effective at preventing infections from certain COVID-19 variants.

Momen said she needs more people who look like her and her family to advocate for vaccines and play a greater role in developing them. Only then, Momen said, will she gain enough confidence to accept any vaccine used against the coronavirus.

"A blessing in disguise"

Kymberly Hartfield, 45, began following headlines about COVID-19 when it was still just a blip in the American news cycle. When China started to construct pop-up hospitals in Wuhan to treat patients of a mysterious pneumonia-like illness, Hartfield said she sensed catastrophe and "really started paying attention to what was going on with the virus."

Hartfield, a Black mother of three and a community activist in Marietta, Georgia, has avoided vaccines for years; she has never gotten a flu shot. When the Trump administration appeared to inject politics into public health campaigns, such as promising that a vaccine would be ready ahead of Election Day, "I was a firm 'hell no,'" Hartfield said.

"Most people recognize there's systemic, structural changes that need to be made and the appetite to do so is greater than ever."

Yet Hartfield kept a close eye on the vaccine effort. From her perspective, Operation Warp Speed "eliminated red tape," and the technology used to develop the two first vaccines had been advanced over several years, not rushed overnight. That gave Hartfield "valid reasons to trust the speed of it all," she said.

It wasn't until Christmas during a phone call with her Great Aunt Lois when she made up her mind to get vaccinated. Her 79-year-old aunt lives nearly 400 miles away in Moss Point, Mississippi, and has been a fixture throughout Hartfield's life.

Being unable to see her aunt for months on end has been one of the hardest things for Hartfield to accept about the pandemic, she said. Her aunt isn't comfortable using computers or even smartphones ("she's just super old school"), so Hartfield can't text her aunt photos or see her facial expressions when they do catch up on the phone. When her aunt asked Hartfield if she planned to get vaccinated for COVID-19, Hartfield said no.

"'If you're not going to get vaccinated, how are we going to see each other?'" Hartfield said her aunt asked.

That struck Hartfield. And then she heard a doctor quoted in a news report say, "Whatever the side effects are, we can treat that easily. It's COVID we can't treat easily."

"That made sense to me," Hartfield said. And together with missing Great Aunt Lois, Hartfield's misgivings eased.

"It's overwhelming to the point where people give up and say, 'If it happens, it happens. I've got other things to deal with. I don't need another hard thing to deal with.'"

The coronavirus and George Floyd's death exposed rampant inequalities in the U.S. with such force that "there's no turning back," Hartfield said. "Most people recognize there's systemic, structural changes that need to be made and the appetite to do so is greater than ever. That's why I call it a blessing in disguise."

But if public health officials think they can convince skeptical people in Black communities to get vaccinated, they won't, Hartfield added. Instead, she said, experts should offer transparent information to these communities and empower them to decide for themselves - as she did. To get there, she thinks that policymakers and public health officials must be more creative in reaching out to communities of color and people who are discouraged and struggling to pay the rent and feed their families: "It's overwhelming to the point where people give up and say, 'If it happens, it happens. I've got other things to deal with. I don't need another hard thing to deal with.'"

"With COVID, we know what's happening"

Over time, Dr. James Hildreth's sister began to change her mind about getting vaccinated for COVID-19, he said. It took several weeks of seeing friends and colleagues in her community get their shots to make her more comfortable. Now she is asking him which of the approved COVID-19 vaccines she should get.

More than simply "hearing information that you need to hear," Hildreth said, it is important for his sister and others to be "hearing it from someone that you trust."

Stories like Hildreth's may soon be more abundant as more and more people get vaccinated and trust grows. But monitoring just how equitably federal, state and local governments handle distribution may still present challenges. In a recent report from the Centers for Disease Control and Prevention, there was no race or ethnicity data for roughly half of all vaccine doses distributed from mid-December to mid-January. That's problematic, Hildreth said, because until the U.S. keeps better records, "we can't truly know what the real disparity is. We need to collect the data to know where all our resources need to be."

Freddie Lee Tyson's experience, and the larger history of atrocities weigh on his daughter every day. To ensure no family suffers in the same way, Christian, her siblings and the descendants of those 623 men established the Voices For Our Fathers Foundation to honor their legacy and hold the U.S. government accountable to history.

"The men had no idea," Christian said. "With COVID, we know what's happening. We know about the facts."

The virus is real and has killed more than 500,000 in the U.S. The vaccines, developed by "the best minds in the world," are the best way to end this pandemic, Christian said. So she, too, has decided to get vaccinated because the only way out is to "rely on science. We have to believe in science."

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For Americans of color considering the COVID-19 vaccine, here's why trust is so important

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"'Are we going to be guinea pigs for the vaccine?'" For months, Dr. James Hildreth's sister had been asking questions like this. While public health officials were urging Americans to take measures to help stop the coronavirus, high rates of infection within Black communities fueled his sister's mistrust, said Hildreth, the president of Meharry Medical College, an historically Black institution in Nashville.

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Positive reflection of why Vaccinations are good news 

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Positive reflection of why Vaccinations are good news 

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The biotech company Moderna released new data Monday morning that strengthens the case for its COVID-19 vaccine. It concludes the vaccine is 94% effective - and strongly protects against serious illness. Based on these latest findings, the company plans to submit an application for emergency use authorization to the Food and Drug Administration today.

They build on Moderna's previously reported findings, based on a smaller number of cases detected in its study of about 30,000 volunteers.

Overall, the study identified 185 cases in the people who received a placebo shot, compared with 11 cases in people who got the active vaccine. These latest findings are similar to results from Pfizer, which has developed a similar vaccine. And, like the Pfizer vaccine, this one seems to prevent severe cases.

"There were 30 cases on placebo and zero cases that were on the vaccine," says Dr. Stephen Hoge, the president of Moderna. "So, it looks like in the trial we've been 100% effective at preventing severe COVID-19, which is really what's driving the burden of disease in hospitals and ultimately straining our public health systems."

Based on those findings - and an analysis of the vaccine's safety and side effects - Moderna has decided it has enough information to submit an application to the FDA. The agency will consider granting emergency use authorization for the product in the coming weeks.

"They will receive a good stack of paper," Hoge says, "but they've been receiving paper almost continuously from when we started."

Pfizer applied for emergency use authorization on Nov. 9 for its COVID-19 vaccine. The FDA will hold its advisory committee to discuss that application on Dec. 10. That meeting is open to the public.

The FDA's charge is to assure that drugs are both safe and effective, and the agency says it is not cutting corners when it comes to COVID-19 vaccines, which will potentially be given to many millions of healthy people.

"They still have an important and solemn responsibility to review that data and develop an independent perspective on it," Hoge says, "and that's not an easy thing to do on a short time horizon."

Moderna expects that on Dec. 17, the FDA will be ready for a public meeting to discuss this data. A vaccine could get the thumbs-up shortly thereafter. Either or both the Pfizer and Moderna vaccines may start to become available in mid to late December, though supplies will be limited.

Both use the same novel technology. Instead of injecting a weakened or dead virus, which is a common strategy for vaccines, these products are essentially small pieces of genetic material. When that's injected into a person's arm, it's picked up by cells in the immune system. The cells read the genetic code and use that to produce a protein that is actually a key fragment of the coronavirus. The body then builds antibodies that latch onto that fragment, so if and when someone encounters the actual coronavirus, the body is primed to fight it off with antibodies.

Though the key action is happening at a cellular level, inoculation can trigger noticeable symptoms, ranging from a sore arm to achiness, or even fever and flu-like symptoms.

Dr. Carlos del Rio, a vaccine scientist at Emory University in Atlanta, was involved in testing the Moderna vaccine. The symptoms he saw were quite similar to symptoms people get when they get the shingles vaccine. For many, the shingles vaccine creates a strong reaction.

"You feel terrible for a day or two but then you're fine," del Rio says.

That's the price of getting a vaccine that protects you, in the case of COVID-19, from a potentially deadly disease. But del Rio says it is a complication in administering the vaccine, because people who get these symptoms after a shot might think the vaccine actually gave them COVID-19.

"We're going to have to do very good messaging to explain to people this is not COVID, it's a side effect of the vaccine and it's OK to have it," del Rio says. "It actually means the vaccine is working."

The vaccine studies have been designed to show whether a shot prevents someone from falling ill. But scientists don't yet know whether people who are vaccinated can still get infected but remain without symptoms. That's important because if a vaccine can prevent even silent infections, it can further reduce the spread of the pandemic.

Hoge said the company is collecting data to look for those silent infections among vaccinated volunteers, but that information won't be in hand until early next year. So, it's possible that some people who are vaccinated can still spread the virus.

"That's why I tell people when you get vaccinated, continue wearing your mask," del Rio says. "We're going to know later if the vaccine actually prevents infection."

He says it's remarkable how quickly all this has come together - less than a year from the time the novel coronavirus was first identified, to now, apparently on the verge of having tens of millions of doses of vaccine ready to go.

"A vaccine that prevents people from getting, sick, especially from getting critically ill? It's a great vaccine right now," del Rio says. With nearly 2,000 deaths per day, "My God, we really need this vaccine."
You can contact NPR Science Correspondent Richard Harris at rharris@npr.org.

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Moderna's COVID-19 Vaccine Candidate Gets More Good News

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The biotech company Moderna released new data Monday morning that strengthens the case for its COVID-19 vaccine. It concludes the vaccine is 94% effective - and strongly protects against serious illness. Based on these latest findings, the company plans to submit an application for emergency use authorization to the Food and Drug Administration today.

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Centers for Disease Control and Prevention

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CDC's home for COVID-19 data. Visualizations, graphs, and data in one easy-to-use website.

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Centers for Disease Control and Prevention

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Symptoms, testing, what to do if sick, daily activities, and more.