# data[].attributes.headline
Q2: What is the main mechanism to increase oxygen supply to active myocardium?

# data[].attributes.subject
Q2: What is the main mechanism to increase oxygen supply to active myocardium?

# data[].attributes.body
Increase coronary blood flow via vasodilation of coronary vasculature? Vasodilators such as nitric oxide will have a direct effect on coronary vasculature to decrease the vasculature tone so that the diameter of the vessels increase to accommodate more blood.

# data[].attributes.body
The patient describes the chest pain as squeezing sensation during exercise which is caused by occlusion or narrowing of coronary arteries (angina attack)

# data[].attributes.headline
Q6: Explain why patients with dilated cardiomyopathy have increased myocardial oxygen consumption.

# data[].attributes.subject
Q6: Explain why patients with dilated cardiomyopathy have increased myocardial oxygen consumption.

# data[].attributes.body
Dilated cardiomyopathy means the ventricles stretch and become thinner, therefore cannot produce myocardial contraction as strong as before. Decrease in contractility will reduce stroke volume. Therefore, heart rate will increase to pump more blood to sustain the blood supply to the body. This leads to the increase in oxygen demand of myocardium. At the same time, increase in heart rate will decrease coronary perfusion due to shorter diastole.

# data[].attributes.headline
5.Explain why nitroglycerin is prescribed to patients with angina pectoris.

# data[].attributes.subject
5.Explain why nitroglycerin is prescribed to patients with angina pectoris.

# data[].attributes.body
Nitroglycerin belongs to a class of drugs known as vasodilators.  It works by decreasing the smooth muscle tonus through the production of Nitric Oxide (NO). NO is known to decrease coronary vascular resistance thereby improving myocardial contractility and metabolic function.

# data[].attributes.body
Nitric oxide causes vasodilation of the coronary arteries which helps in accommodating more volume of blood and thereby allows more blood flow

# data[].attributes.headline
Q1: What is the basis of this patient's complaints?

# data[].attributes.subject
Q1: What is the basis of this patient's complaints?

# data[].attributes.body
Coronary artery disease- stable angina. Atherosclerotic plaque impedes blood flow in coronary artery, but not to a very significant extent. Therefore chest pain can only be felt during exertion.

# data[].attributes.body
At rest:
- beta oxidation of fatty acids
- carbohydrate metabolism
During exercise:
- lactate produced by skeletal muscles is converted to pyruvate

# data[].attributes.headline
4. What is the role of nitric oxide in the perfusion of coronary tissue?

# data[].attributes.subject
4. What is the role of nitric oxide in the perfusion of coronary tissue?

# data[].attributes.body
NO relaxes the arterial smooth muscle which makes it vasodilate thereby causing blood flow to increase.

# data[].attributes.headline
6. Explain why patients with dilated cardiomyopathy have increased myocardial oxygen consumption.

# data[].attributes.subject
6. Explain why patients with dilated cardiomyopathy have increased myocardial oxygen consumption.

# data[].attributes.headline
5. Explain why nitroglycerin is prescribed to patients with angina pectoris.

# data[].attributes.subject
5. Explain why nitroglycerin is prescribed to patients with angina pectoris.

# data[].attributes.headline
4. What is the role of nitric oxide in the perfusion of coronary tissue?

# data[].attributes.subject
4. What is the role of nitric oxide in the perfusion of coronary tissue?

# data[].attributes.headline
3. What are the sources of energy to support cardiac muscle metabolism at rest and during exercise?

# data[].attributes.subject
3. What are the sources of energy to support cardiac muscle metabolism at rest and during exercise?

# data[].attributes.headline
2. What is the main mechanism to increase oxygen supply to active myocardium?

# data[].attributes.subject
2. What is the main mechanism to increase oxygen supply to active myocardium?

# data[].attributes.headline
1. What is the basis of this patient’s complaints?

# data[].attributes.subject
1. What is the basis of this patient’s complaints?