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file:///C:/Users/safil/AppData/Local/Temp/kevin_rc_thesis.pdf

https://www.chm.uri.edu/forensics/Gurney_PharmToxAdverseEffectsSynCannDrugs_ForScReview_2014.pdf

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https://en.wikipedia.org/wiki/ADB-PINACA

http://alphalab24.com/cannibinoids/5f-adb/

https://www.google.co.uk/search?q=ADB+pinaca&dcr=0&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjOns32zOnZAhXECsAKHfXAB60Q_AUICigB&biw=1920&bih=971#imgrc=eHnuKgbP-_dqaM:

https://padlet-uploads.storage.googleapis.com/272372482/2c1bfbad379ae19282f9b58c1423a2fe/medical_synthetic_cannabis_blog_full.jpg

https://www.google.co.uk/search?q=cannabinoids+synthetic&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi4sefW2OnZAhUBKsAKHTVjCw8Q_AUICygC&biw=1920&bih=971#imgrc=rjEvQMaLogDk-M:

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Recreational drugs are mostly used for mood relaxation/stress relief. ADB-PINACA along with JWH is a compound found in cannabinoids and is a substitute for Marijuana as the structure is similar along with both binding to a G-coupled protein receptor called CB1. It is also used at a lower dose to reduce the risk of toxicity to an individual.

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In conclusion, ADB-PINACA (having being derived from Cannabis) has many negative qualities including myocardial damage, strokes and even acute renal failure, being one of 113 versions of a cannabinoid. With the only benefits of taking the drug being euphoria, relaxation and creative thinking it can be seen that for the most part the bad outweighs the good however, few studies and research has shown that there can be beneficial circumstances to taking this drug (or similar cannabinoids). They are sometimes able to increase energy levels and appetite in some cases, which is ideal for patients with diseases such as cancer or HIV who may have no appetite and may have low levels of energy.

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· Cannabinoid was first established as a recreational drug landscape in the US.

· The drugs were distributed, manufactured in laboratories also the smoking mixtures had similar effects to use of marijuana.

· Legislation for Cannabinoids was introduced into many countries to reduce the spread of existing drugs.

· In the UK many cannabinoids are strictly under control. For instance, the countries whose drugs legislation are now control for these drugs are Germany, Netherlands and France etc. The majority of these countries have altered their system.

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Cannabimetic synthetic cannabinoids are widespread new psychoactive substances (NPS) producing side effects such as convulsions, myocardial damage, stroke and acute renal failure. The creation of synthetic compounds with cannabinoid-like effects was motivated by the illegal status of marijuana in several countries, such as the United States. The desired effects include mood elevation, euphoria, relaxation, creative thinking, and increased sensory awareness. In an attempt to prevent damage, judicial authorities around the world are trying to control the distribution of NPS; however, new structural classes continually emerge to circumvent these laws, leading to a plethora of targets.

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ADB-PINACA is a synthetic cannabinoids, these drugs are known to present pharmacological effects by interacting with CB1 and CB2 receptors situated all along the peripheral nervous system. Generally, the CB1 receptors are responsible for the psychotropic effects of cannabis and thus the ability of a ligand to bind to and work as an agonist at the CB1 receptor may show its potential as an alternative to ADB PINACA for recreational utilisation. The change of mood (panic, elevation or anxiety) causes the interaction with the CB1 receptors. Furthermore, hypothermia hypomobility marked.

The role of CB2 receptors is largely as an immunosuppressant and potential therapeutic factor, Ligands which interact with the CB2 receptors are gainful in the diminution of inflammatory pain that results in peripheral antinociception.