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"Genetic Analysis of Immune Disorders - Full Text View - ClinicalTrials.gov." Home - ClinicalTrials.gov. N.p., n.d. Web. 16 Feb. 2016.

"MAGT1 - Magnesium Transporter 1." Genetics Home Reference. N.p., n.d. Web. 16 Feb. 2016.

"Signaling Role for Mg2+ Revealed by Immunodeficiency Due to Loss of MagT1." PubMed Central (PMC). N.p., n.d. Web. 16 Feb. 2016.

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Signs and Symptoms

Symptoms include constant infections such as recurrent otitis media, sinusitis, viral pneumonia, diarrhea, upper respiratory infections, epiglottitis, and pertussis. (Signaling)

Basically lots of infections.

Caused by the lack of function of T-cells (cells that fight against infections and disease) due to lack of magnesium transporter

Magnesium transporter production is slowed by XMEN disease

Possible Treatments

Treatments include Hematopoietic stem cell transplant, replacing mutated gene with a new, normal gene. Effectiveness of transplant has been proven.

Continuous oral magnesium threonate supplementation has shown promising results (Genetic)

Life Expectancy

The life expectancy of a victim of EBV lymphoma can be as small as about 30 d (most commonly a result of XMEN)

Prenatal Testing

Prenatal tests consist of collected samples of magnesium transporter from the baby and testing the effectiveness and the amount of magnesium transporter present in the body.

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"XMEN." Genetics Home Reference. US National Library of Medicine, June 2014. Web. 16 Feb. 2016.

Johnson, Cort. "The Epstein-Barr Virus, Magnesium and ME/CFS Connection." SimmaronResearch.com. Simmaron Research, 22 Aug. 2015. Web. 16 Feb. 2016.

"General Care." PrimaryImmune.org. Immune Deficiency Foundation, n.d. Web. 16 Feb. 2016

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Name

XMEN Disease aka immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection, and neoplasia

Gene Location/Karyotype

Located on the X chromosome

Mutation is located on the longer arm of the X chromosome in the 21.1. on the MAGT1 gene (MAGT1)

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A. Classification

Single gene defect classification (XMEN)

Inherited in an X-linked recessive pattern (XMEN)

B. Disorder arousal

Recessive

Refer to Pedigree Chart

C. Frequency

Very rare, more common in men than in women (Johnson)

D. Advisement

Individualized supplement intake (General Care)