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distinguished from other hotspots by its arid or semi-arid climate, allowing for a rich diversity of succulent plants and animals

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https://enviroliteracy.org/ecosystems/hotspots-of-biodiversity/succulent-karoo/
http://www.conservation.org/global/ci_south_africa/where-we-work/succulent-karoo/Pages/succulent-karoo.aspx

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Only 2-3% of the Succulent Karoo habitat is formally protected.

Large reserves including: Richtersveld and Namaqua National Parks

The National Biodiversity Institute of South Africa also has a number of conservation projects underway, including the Succulent Karoo Ecosystem Programme (SKEP)

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mining activities, overgrazing and the illegal collection and trade of its succulent plants.

climate change

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The hotspot is itself a very fragile ecosystem as evidenced by 28 species of plants dependent exclusively on two types of long-tongued flies