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Rheumatology | Dermatomyositis / Polymyositis

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Specific pathophysiology is not known yet; however, it is thought that the cascade of clinical effects for this autoimmune inflammatory disease affecting the perifascicular region of skeletal muscles is driven by anti-Mi2, anti-Jo1, and anti-P155/P140 antibodies.

Clinical manifestations:

Anti-Mi2 antibodies (Gottron papules, and heliotrope rash).

Anti-Jo1 antibodies (mechanic’s hands).

Anti-P155/P140 antibodies (paraneoplastic and juvenile DM).

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Dalakas MC. Mechanisms of disease: signaling pathways and immunobiology of inflammatory myopathies. Nat Clin Pract Rheumatol. 2006 Apr;2(4):219-27. doi: 10.1038/ncprheum0140.