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recruit subjects from oncology clinics. baseline survey on diet. follow up period 5 years, 6 monthly follow ups to calculate person/month incidence rate.
challenges: loss to follow up due to severe illness, recruitment difficult during time of high stress, recall bias possibility, drug type given possible confounder due lack of appetite as well as effect on cancer.

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recruit patient of pancreatic cancer from cancer registry as case group and recruit the control gropup using matching characteristic of each case.

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how to measure fruit intake?
-self report of how many serves per day on average, but they must first have explained to them how much a serve is. There could be social desirability bias if asked face to face

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recruitment: people diagnosed with pancreatic cancer

follow-up time: person-months

fruit intake definition (low intake, high intake)

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Methodological Challenges

=> Definition of fruit intake
=> What type of fruit intake we are going to look at
=> How much fruit they intake
=> Whether the fruit is organic or not. (raw or cooked fruit)
=> Confounding effects (We should look at another risk factors.)

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Recruitment: all patients with pancreatic cancer
Fruit status quantity: low vs. high intake
Follow up time: person-months?
length of study: 6 years

Methodological challenges:
- dropout due to sickness

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- target population: pancreatic cancer
- define fruit intake (what kind of fruits)
- compare high, moderate and low intake
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Cohort group: people who are diagnosed with pancreatic cancer

categorise them into different groups according to their level of fruit intake (low, moderate, high)

compare the incidence rate among each group

methodological challenges: difference in variety of fruits

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Recruitment: persons who diagnose with pancreatic cancer(accroding to ICD-10)
Follow-up time: person-mouth
Challenges: loss to follow up
some people die from pancreatic cancer
some people  .

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Recruit: people have already been diagnosed with pancreatic cancer Follow up time: from the beginning of the study up to 5 years(person-mouth) Challenges: fruit eating is not the only factor that may extend their survival rate, need to consider and adjust these factors(e.g.

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If you were to design a prospective cohort study to assess the following question, what would be the optimal design (recruitment, follow-up time etc.) and what would be the methodological challenges?

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If you were to design a prospective cohort study to assess the following question, what would be the optimal design (recruitment, follow-up time etc.) and what would be the methodological challenges?

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Whether high intake of fruits  improves survival in persons diagnosed with pancreatic cancer.