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Sickle cell disease is a disorder that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells in the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

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Sickle cell disease is a disorder that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells in the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

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People with this disorder have atypical hemoglobin molecules, referred to as  Hemoglobin S, which can distort the cells into a sickle shape.

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People with this disorder have atypical hemoglobin molecules, referred to as  Hemoglobin S, which can distort the cells into a sickle shape.

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It is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. Each parent carries one copy of the mutated gene, but typically do not show signs and symptoms of the condition.

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It is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. Each parent carries one copy of the mutated gene, but typically do not show signs and symptoms of the condition.

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When red blood cells sickle, they break down prematurely, which can lead to anemia, which can cause shortness of breath, fatigue, and inhibit growth in young children. 

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When red blood cells sickle, they break down prematurely, which can lead to anemia, which can cause shortness of breath, fatigue, and inhibit growth in young children. 

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Episodes can occur when sickled cells, which are stiff and inflexible, get stuck in small blood vessels and restrict blood flow to organs, causing swelling and pain.

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Episodes can occur when sickled cells, which are stiff and inflexible, get stuck in small blood vessels and restrict blood flow to organs, causing swelling and pain.

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Mutations in the HBB gene cause Sickle Cell Disease.

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Mutations in the HBB gene cause Sickle Cell Disease.

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Treatments might include medications and blood transfusions. For some children and teenagers, a stem cell transplant might cure the disease.

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Treatments might include medications and blood transfusions. For some children and teenagers, a stem cell transplant might cure the disease.