# data[].attributes.attachment_link.embed_code
Yeah ban me already
by u/SweettLemons in GoCommitDie

# data[].attributes.body
wah.

# data[].attributes.attachment_link.description
Play music together live on the web with this simple tool for remote teaching and collaboration.

# data[].attributes.body
when takeing a giant shit

# data[].attributes.attachment_link.title
Man Screaming - CEEDAY Sound Effect (HD)

# data[].attributes.attachment_link.metadata.title
Man Screaming - CEEDAY Sound Effect (HD)

# data[].attributes.attachment_link.description
Mecabricks is the first web service to publish and display 3D models made with LEGO® bricks. No need to install any plugin, it simply works.

# data[].attributes.headline
3 days since the last communication with outside members of this hierarchy society, I instruct urgent care of thy rest place

# data[].attributes.subject
3 days since the last communication with outside members of this hierarchy society, I instruct urgent care of thy rest place

# data[].attributes.headline
yeah, i'm fine people are just a little mean sometimes

# data[].attributes.subject
yeah, i'm fine people are just a little mean sometimes

# data[].attributes.attachment_link.title
Sign up | Miro | Online Whiteboard for Visual Collaboration

# data[].attributes.attachment_link.description
Scalable, secure, cross-device and enterprise-ready team collaboration whiteboard for distributed teams. Join 35M+ users from around the world

# data[].attributes.attachment_link.title
🚨Toilet Rescue Patrol🚨 Talking Tom Shorts 46

# data[].attributes.attachment_link.title
⚽🕺EPIC SPORTS SHORTS! ⚽ Talking Tom Shorts (Cartoon Compilation)

# data[].attributes.attachment_link.title
Red Dead Redemption 2 - Arthur Tells Sister He's Dying & Is Afraid (Very Sad Cutscene)

# data[].attributes.body
and they cut it up and widebody it

# data[].attributes.headline
now listen here, you little *classical music*

# data[].attributes.subject
now listen here, you little *classical music*

# data[].attributes.body
dickdickdickmine

# data[].attributes.attachment_link.description
Burritocraft is real Minecraft 1.5.2 that you can play in any regular web browser. That includes school chromebooks, it works on all chromebooks. It supports both singleplayer and multiplayer with no extensions.

# data[].attributes.headline
guys what if i told you i said dick randomly, its a disorder

# data[].attributes.subject
guys what if i told you i said dick randomly, its a disorder

# data[].attributes.headline
SOON WE  WILL BE HARVESTING MANGOES IN TAHITI

# data[].attributes.subject
SOON WE  WILL BE HARVESTING MANGOES IN TAHITI

# data[].attributes.headline
Jack i was saying hi like an npc in the cience room door and you didnt see me

# data[].attributes.subject
Jack i was saying hi like an npc in the cience room door and you didnt see me

# data[].attributes.attachment_link.keywords[]
Boats and boating--Equipment and supplies

# data[].attributes.body
they turn into a balll and when you throw them on the ground they turn into a car

# data[].attributes.headline
some times you just wanna DictionaryDefinitions from Oxford Languages · Learn moreSearch for a wordsis·sy/ˈsisē/DEROGATORY•INFORMALnounnoun: sissy; plural noun: sissies; noun: cissy; plural noun: cissiesa soft, timid, or oversensitive person, or a boy or man viewed as being overly interested in things traditionally associated with women."he would hate the other boys to think he was a sissy"Similar:cowardweaklingnamby-pambycrybabybabymilquetoastsoftiesnowflakechickenmilksopmama's boywetweedbig girl's blousejessieponcepantywaistcupcakepussysookpoltroonadjectiveadjective: sissy; comparative adjective: sissier; superlative adjective: sissiest; adjective: cissy; comparative adjective: cissier; superlative adjective: cissiestsoft, timid, or oversensitive, or overly interested in things traditionally associated with women."they still think that dancing is a sissy thing for guys to do"Similar:cowardlyweakfeeblespinelesseffeminateeffetelimp-wristedwomanishunmanlysoftwetweedywimpishwimpysissyishsissifiedswishyyellowyellow-belliedcandy-assedOriginmid 18th century (in the sense ‘sister’): from sis1 + -y2.Translate sissy toChoose languageUse over time for: sissyFeedback

# data[].attributes.subject
some times you just wanna DictionaryDefinitions from Oxford Languages · Learn moreSearch for a wordsis·sy/ˈsisē/DEROGATORY•INFORMALnounnoun: sissy; plural noun: sissies; noun: cissy; plural noun: cissiesa soft, timid, or oversensitive person, or a boy or man viewed as being overly interested in things traditionally associated with women."he would hate the other boys to think he was a sissy"Similar:cowardweaklingnamby-pambycrybabybabymilquetoastsoftiesnowflakechickenmilksopmama's boywetweedbig girl's blousejessieponcepantywaistcupcakepussysookpoltroonadjectiveadjective: sissy; comparative adjective: sissier; superlative adjective: sissiest; adjective: cissy; comparative adjective: cissier; superlative adjective: cissiestsoft, timid, or oversensitive, or overly interested in things traditionally associated with women."they still think that dancing is a sissy thing for guys to do"Similar:cowardlyweakfeeblespinelesseffeminateeffetelimp-wristedwomanishunmanlysoftwetweedywimpishwimpysissyishsissifiedswishyyellowyellow-belliedcandy-assedOriginmid 18th century (in the sense ‘sister’): from sis1 + -y2.Translate sissy toChoose languageUse over time for: sissyFeedback

# data[].attributes.body
pussy in booty

# data[].attributes.body
this is dead

# data[].attributes.body
Add a few sections that take up the whole screen that are completely clean chats so we can go there when teachers are looking.

# data[].attributes.headline
The FitnessGram™ Pacer Test is a The FitnessGram™ Pacer Test is a multistage aerobic capacity test that progressively gets more difficult as it continues. The 20 meter pacer test will begin in 30 seconds. Line up at the start. The running speed starts slowly, but gets faster each minute after you hear this signal. [beep] A single lap should be completed each time you hear this sound. [ding] Remember to run in a straight line, and run as long as possible. The second time you fail to complete a lap before the sound, your test is over. The test will begin on the word start. On your mark, get ready, start.

# data[].attributes.subject
The FitnessGram™ Pacer Test is a The FitnessGram™ Pacer Test is a multistage aerobic capacity test that progressively gets more difficult as it continues. The 20 meter pacer test will begin in 30 seconds. Line up at the start. The running speed starts slowly, but gets faster each minute after you hear this signal. [beep] A single lap should be completed each time you hear this sound. [ding] Remember to run in a straight line, and run as long as possible. The second time you fail to complete a lap before the sound, your test is over. The test will begin on the word start. On your mark, get ready, start.

# data[].attributes.body
*slurp*

# data[].attributes.body
men i love

# data[].attributes.headline
We reunite today brothers in the cult of bumshala

# data[].attributes.subject
We reunite today brothers in the cult of bumshala

# data[].attributes.headline
MAKE AMERICA GREAT AGAIN, TRUMP 2024 RAAAH🦅🇺🇸

# data[].attributes.subject
MAKE AMERICA GREAT AGAIN, TRUMP 2024 RAAAH🦅🇺🇸

# data[].attributes.body
no more old messages.

# data[].attributes.headline
You know when Depression is a mental state of low mood and aversion to activity,[3] which affects more than 280 million people of all ages (about 3.5% of the global population).[4] Classified medically as a mental and behavioral disorder,[5] the experience of depression affects a person's thoughts, behavior, motivation, feelings, and sense of well-being.[6] The core symptom of depression is said to be anhedonia, which refers to loss of interest or a loss of feeling of pleasure in certain activities that usually bring joy to people.[7] Depressed mood is a symptom of some mood disorders such as major depressive disorder and dysthymia;[8] it is a normal temporary reaction to life events, such as the loss of a loved one; and it is also a symptom of some physical diseases and a side effect of some drugs and medical treatments. It may feature sadness, difficulty in thinking and concentration and a significant increase or decrease in appetite and time spent sleeping. People experiencing depression may have feelings of dejection, hopelessness and suicidal thoughts. It can either be short term or long term.Contents1	Factors1.1	Life events1.2	Personality1.3	Alcoholism1.4	Bullying1.5	Medical treatments1.6	Substance-induced1.7	Non-psychiatric illnesses1.8	Psychiatric syndromes1.9	Historical legacy2	Measures3	Creative thinking4	Theories5	Management6	Epidemiology7	History8	See also9	References10	External linksFactorsAllegory on melancholy, from circa 1729–40, etching and engraving, dimensions of the sheet: 42 × 25.7 cm, in the Metropolitan Museum of Art (New York City)Life eventsAdversity in childhood, such as bereavement, neglect, mental abuse, physical abuse, sexual abuse, or unequal parental treatment of siblings can contribute to depression in adulthood.[9][10] Childhood physical or sexual abuse in particular significantly correlates with the likelihood of experiencing depression over the survivor's lifetime.[11]Life events and changes that may influence depressed moods include (but are not limited to): childbirth, menopause, financial difficulties, unemployment, stress (such as from work, education, family, living conditions etc.), a medical diagnosis (cancer, HIV, etc.), bullying, loss of a loved one, natural disasters, social isolation, rape, relationship troubles, jealousy, separation, or catastrophic injury.[12][13][14][15][16] Adolescents may be especially prone to experiencing a depressed mood following social rejection, peer pressure, or bullying.[17]The global pandemic of COVID-19 has negatively impacted upon many individuals' mental health, causing levels of depression to surge, reaching devastating heights. A study conducted by the University of Surrey in autumn 2019 and May/June 2020 looked into the impact of COVID-19 upon young people's mental health. This study is published in the Journal of Psychiatry Research Report.[18] The study showed a significant rise in depression symptoms and a reduction in overall wellbeing during lockdown (May/June 2020) compared to the previous Autumn (2019). Levels of clinical depression in those surveyed in the study were found to have more than doubled, rising from 14.9 per cent in Autumn 2019 to 34.7 per cent in May/June 2020.[19] This study further emphasises the correlation that certain life events have with developing depression.PersonalityChanges in personality or in one's social environment can affect levels of depression. High scores on the personality domain neuroticism make the development of depressive symptoms as well as all kinds of depression diagnoses more likely,[20] and depression is associated with low extraversion.[21] Other personality indicators could be: temporary but rapid mood changes, short term hopelessness, loss of interest in activities that used to be of a part of one's life, sleep disruption, withdrawal from previous social life, appetite changes, and difficulty concentrating.[22]AlcoholismAlcohol can be a depressant which slows down some regions of the brain, like the prefrontal and temporal cortex, negatively affecting rationality and memory.[23] It also lowers the level of serotonin in the brain, which could potentially lead to higher chances of depressive mood.[24]The connection between the amount of alcohol intake, level of depressed mood, and how it affects the risks of experiencing consequences from alcoholism, were studied in a research done on college students. The study used 4 latent, distinct profiles of different alcohol intake and level of depression; Mild or Moderate Depression, and Heavy or Severe Drinkers. Other indicators consisting of social factors and individual behaviors were also taken into consideration in the research. Results showed that the level of depression as an emotion negatively affected the amount of risky behavior and consequence from drinking, while having an inverse relationship with protective behavioral strategies, which are behavioral actions taken by oneself for protection from the relative harm of alcohol intake. Having an elevated level of depressed mood does therefore lead to greater consequences from drinking.[25]BullyingSocial abuse, such as bullying, are defined as actions of singling out and causing harm on vulnerable individuals. In order to capture a day-to-day observation of the relationship between the damaging effects of social abuse, the survivor's mental health and depressive mood, a study was conducted on whether individuals would have a higher level of depressed mood when exposed to daily acts of negative behavior. The result concluded that being exposed daily to abusive behaviors such as bullying has a positive relationship to depressed mood on the same day.The study has also gone beyond to compare the level of depressive mood between the victims and non-victims of the daily bullying. Although victims were predicted to have a higher level of depressive mood, the results have shown otherwise that exposure to negative acts has led to similar levels of depressive mood, regardless of the victim status. The results therefore have concluded that bystanders and non-victims feel as equally depressed as the victim when being exposed to acts such as social abuse.[26]Medical treatmentsDepression may also be the result of healthcare, such as with medication induced depression. Therapies associated with depression include interferon therapy, beta-blockers, isotretinoin, contraceptives,[27] anticonvulsants, antimigraine drugs, antipsychotics, hormonal agents such as gonadotropin-releasing hormone agonist,[28] magnetic stimulation to brain and electric therapy.Substance-inducedSeveral drugs of abuse can cause or exacerbate depression, whether in intoxication, withdrawal, and from chronic use. These include alcohol, sedatives (including prescription benzodiazepines), opioids (including prescription pain killers and illicit drugs such as heroin), stimulants (such as cocaine and amphetamines), hallucinogens, and inhalants.[29]Non-psychiatric illnessesMain article: Depression (differential diagnoses)Depressed mood can be the result of a number of infectious diseases, nutritional deficiencies, neurological conditions,[30] and physiological problems, including hypoandrogenism (in men), addison's disease, cushing's syndrome, pernicious anemia, hypothyroidism, hyperparathyroidism, Lyme disease, multiple sclerosis, Parkinson's disease, chronic pain, stroke,[31] diabetes,[32] and cancer.[33]Psychiatric syndromesMain article: Depressive mood disordersA number of psychiatric syndromes feature depressed mood as a main symptom. The mood disorders are a group of disorders considered to be primary disturbances of mood. These include major depressive disorder (MDD; commonly called major depression or clinical depression) where a person has at least two weeks of depressed mood or a loss of interest or pleasure in nearly all activities; and dysthymia, a state of chronic depressed mood, the symptoms of which do not meet the severity of a major depressive episode. Another mood disorder, bipolar disorder, features one or more episodes of abnormally elevated mood, cognition, and energy levels, but may also involve one or more episodes of depression.[34] When the course of depressive episodes follows a seasonal pattern, the disorder (major depressive disorder, bipolar disorder, etc.) may be described as a seasonal affective disorder. Outside the mood disorders: borderline personality disorder often features an extremely intense depressive mood; adjustment disorder with depressed mood is a mood disturbance appearing as a psychological response to an identifiable event or stressor, in which the resulting emotional or behavioral symptoms are significant but do not meet the criteria for a major depressive episode;[35]: 355  and posttraumatic stress disorder, a mental disorder that sometimes follows trauma, is commonly accompanied by depressed mood.[36]Historical legacyMain article: Dispossession, oppression and depressionResearchers have begun to conceptualize ways in which the historical legacies of racism and colonialism may create depressive conditions.[37][38]MeasuresMeasures of depression as an emotional disorder include, but are not limited to: Beck Depression Inventory-11 and the 9-item depression scale in the Patient Health Questionnaire (PHQ-9).[39] Both of these measures are psychological tests that ask personal questions of the participant, and have mostly been used to measure the severity of depression. The Beck Depression Inventory (BDI) is a self-report scale that helps a therapist identify the patterns of depression symptoms and monitor recovery. The responses on this scale can be discussed in therapy to devise interventions for the most distressing symptoms of depression.[7] Several studies, however, have used these measures to also determine healthy individuals who are not experincing depression as a mental disorder, but as an occasional mood disorder. This is substantiated by the fact that depression as an emotional disorder displays similar symptoms to minimal depression and low levels of mental disorders such as major depressive disorder; therefore, researchers were able to use the same measure interchangeably. In terms of the scale, participants scoring between 0–13 and 0–4 respectively were considered healthy individuals.[25]Another measure of depressed mood would be the IWP Multi-affect Indicator.[40] It is a psychological test that indicates various emotions, such as enthusiasm and depression, and asks for the degree of the emotions that the participants have felt in the past week. There are studies that have used lesser items from the IWP Multi-affect Indicator which was then scaled down to daily levels to measure the daily levels of depression as an emotional disorder.[26]Creative thinkingDivergent thinking is defined as a thought process that generates creativity in ideas by exploring many possible solutions. Having a depressed mood will significantly reduce the possibility of divergent thinking, as it reduces the fluency, variety and the extent of originality of the possible ideas generated.[41]Some depressive mood disorders might have a positive effect for creativity. Upon identifying several studies and analyzing data involving individuals with high levels of creativity, Christa Taylor was able to conclude that there is a clear positive relationship between creativity and depressive mood. A possible reason is that having a low mood could lead to new ways of perceiving and learning from the world, but it is unable to account for certain depressive disorders. The direct relationship between creativity and depression remains unclear, but the research conducted on this correlation has shed light that individuals who are struggling with a depressive disorder may be having even higher levels of creativity than a control group, and would be a close topic to monitor depending on the future trends of how creativity will be perceived and demanded.[42]TheoriesSchools of depression theories include:Cognitive theory of depressionTripartite Model of Anxiety and DepressionBehavioral theories of depressionEvolutionary approaches to depressionBiology of depressionEpigenetics of depressionManagementMain article: Management of depressionDepressed mood may not require professional treatment, and may be a normal temporary reaction to life events, a symptom of some medical condition, or a side effect of some drugs or medical treatments. A prolonged depressed mood, especially in combination with other symptoms, may lead to a diagnosis of a psychiatric or medical condition which may benefit from treatment. The UK National Institute for Health and Care Excellence (NICE) 2009 guidelines indicate that antidepressants should not be routinely used for the initial treatment of mild depression, because the risk-benefit ratio is poor.[43] Physical activity can have a protective effect against the emergence of depression.[44]Physical activity can also decrease depressive symptoms due to the release of neurotrophic proteins in the brain that can help to rebuild the hippocampus that may be reduced due to depression.[45] Also yoga could be considered an ancillary treatment option for patients with depressive disorders and individuals with elevated levels of depression.[46][47]Reminiscence of old and fond memories is another alternative form of treatment, especially for the elderly who have lived longer and have more experiences in life. It is a method that causes a person to recollect memories of their own life, leading to a process of self-recognition and identifying familiar stimuli. By maintaining one's personal past and identity, it is a technique that stimulates people to view their lives in a more objective and balanced way, causing them to pay attention to positive information in their life stories, which would successfully reduce depressive mood levels.[48]Self-help books are a growing form of treatment for peoples physiological distress. There may be a possible connection between consumers of unguided self-help books and higher levels of stress and depressive symptoms. Researchers took many factors into consideration to find a difference in consumers and nonconsumers of self-help books. The study recruited 32 people between the ages of 18 and 65; 18 consumers and 14 nonconsumers, in both groups 75% of them were female. Then they broke the consumers into 11 who preferred problem-focused and 7 preferred growth-oriented. Those groups were tested for many things including cortisol levels, depressive symptomatology, and stress reactivity levels. There were no large differences between consumers of self-help books and nonconsumers when it comes to diurnal cortisol level, there was a large difference in depressive symptomatology (signs and symptoms) with consumers having a higher mean score. The growth-oriented group has higher stress reactivity levels than the problem-focused group. However, the problem-focused group shows higher depressive symptomatology.[49]There is limited evidence that continuing antidepressant medication for one year reduces the risk of depression recurrence with no additional harm.[50] Recommendations for psychological treatments or combination treatments in preventing recurrence are not clear.[50]There are empirical evidences of a connection between the type of stress management techniques and the level of daily depressive mood.[41]EpidemiologyMain article: Epidemiology of depressionDepression is the leading cause of disability worldwide, the United Nations (UN) health agency reported, estimating that it affects more than 300 million people worldwide – the majority of them women, young people and the elderly. An estimated 4.4 percent of the global population has depression, according to a report released by the UN World Health Organization (WHO), which shows an 18 percent increase in the number of people living with depression between 2005 and 2015.[51][52][53]Depression is a major mental-health cause of disease burden. Its consequences further lead to significant burden in public health, including a higher risk of dementia, premature mortality arising from physical disorders, and maternal depression impacts on child growth and development.[54] Approximately 76% to 85% of depressed people in low- and middle-income countries do not receive treatment;[55] barriers to treatment include: inaccurate assessment, lack of trained health-care providers, social stigma and lack of resources.[56]The stigma comes from misguided societal views that people with mental illness are different from everyone else, and they can choose to get better only if they wanted to.[57] Due to this more than half of the people with depression do not receive help with their disorders. The stigma leads to a strong preference for privacy.The World Health Organization has constructed guidelines – known as The Mental Health Gap Action Programme (mhGAP) – aiming to increase services for people with mental, neurological and substance-use disorders.[56] Depression is listed as one of conditions prioritized by the programme. Trials conducted show possibilities for the implementation of the programme in low-resource primary-care settings dependent on primary-care practitioners and lay health-workers.[58] Examples of mhGAP-endorsed therapies targeting depression include Group Interpersonal Therapy as group treatment for depression and "Thinking Health", which utilizes cognitive behavioral therapy to tackle perinatal depression.[56] Furthermore, effective screening in primary care is crucial for the access of treatments. The mhGAP adopted its approach of improving detection rates of depression by training general practitioners. However, there is still weak evidence supporting this training.[54]HistoryMain article: History of depressionThe term depression was derived from the Latin verb deprimere, "to press down".[59] From the 14th century, "to depress" meant to subjugate or to bring down in spirits. It was used in 1665 in English author Richard Baker's Chronicle to refer to someone having "a great depression of spirit", and by English author Samuel Johnson in a similar sense in 1753.[60]In Ancient Greece, disease was thought due to an imbalance in the four basic bodily fluids, or humors. Personality types were similarly thought to be determined by the dominant humor in a particular person. Derived from the Ancient Greek melas, "black", and kholé, "bile",[61] melancholia was described as a distinct disease with particular mental and physical symptoms by Hippocrates in his Aphorisms, where he characterized all "fears and despondencies, if they last a long time" as being symptomatic of the ailment.[62]During the 18th century, the humoral theory of melancholia was increasingly being challenged by mechanical and electrical explanations; references to dark and gloomy states gave way to ideas of slowed circulation and depleted energy.[63] German physician Johann Christian Heinroth, however, argued melancholia was a disturbance of the soul due to moral conflict within the patient.In the 20th century, the German psychiatrist Emil Kraepelin distinguished manic depression. The influential system put forward by Kraepelin unified nearly all types of mood disorder into manic–depressive insanity. Kraepelin worked from an assumption of underlying brain pathology, but also promoted a distinction between endogenous (internally caused) and exogenous (externally caused) types.[64] Around 1980, Kraepelin defined the term manic depression, which is also known as bipolar disorder. This mental health condition causes people to have mood swings, such as emotional highs and lows. Manic depression and bipolar disorder are considered the same thing because of these mood swings.[citation needed]Other psycho-dynamic theories were proposed. Existential and humanistic theories represented a forceful affirmation of individualism.[65] Austrian existential psychiatrist Viktor Frankl connected depression to feelings of futility and meaninglessness.[66] Frankl's logotherapy addressed the filling of an "existential vacuum" associated with such feelings, and may be particularly useful for depressed adolescents.[67][68]Researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms.[69] During the 1960s and 70s, manic-depression came to refer to just one type of mood disorder (now most commonly known as bipolar disorder) which was distinguished from (unipolar) depression. The terms unipolar and bipolar had been coined by German psychiatrist Karl Kleist.[64]In July 2022, British psychiatrist Joanna Moncrieff, also psychiatrist Mark Horowtiz and others proposed in a study on academic journal Molecular Psychiatry that depression is not caused by a serotonin imbalance in the human body, unlike what most of the psychiatry community points to, and that therefore anti-depressants don't work against the illness.[70][71] However, such study was met with criticism from some psychiatrists, who argued the study's methodology used an indirect trace of serotonin, instead of taking direct measurements of the molecule.[72] Moncrieff said that, despite her study's conclusions, no one should interrupt their treatment if they are taking any anti-depressant.[73]See alsoAttribution (psychology)Biopsychosocial modelDepression in childhood and adolescenceDiathesis–stress modelExistential crisisFeelingLocus of controlMelancholiaMixed anxiety–depressive disorderReferences "Depression". Cleveland Clinic. 2022. Retrieved 9 June 2022. Shrivastava A, Bureau Y, Rewari N, Johnston M (April 2013). "Clinical risk of stigma and discrimination of mental illnesses: Need for objective assessment and quantification". Indian Journal of Psychiatry. 55 (2): 178–82. doi:10.4103/0019-5545.111459. PMC 3696244. PMID 23825855. "NIMH » Depression Basics". www.nimh.nih.gov. 2016. Archived from the original on 11 June 2013. Retrieved 22 October 2020. "Depression". www.who.int. Archived from the original on 26 December 2020. Retrieved 7 April 2021. Sartorius N, Henderson AS, Strotzka H, Lipowski Z, Yu-cun S, You-xin X, et al. "The ICD-10 Classification of Mental and Behavioural Disorders Clinical descriptions and diagnostic guidelines" (PDF). www.who.int World Health Organization. pp. 30–1. Archived (PDF) from the original on 17 October 2004. Retrieved 23 June 2021. de Zwart PL, Jeronimus BF, de Jonge P (October 2019). "Empirical evidence for definitions of episode, remission, recovery, relapse and recurrence in depression: a systematic review". Epidemiology and Psychiatric Sciences. 28 (5): 544–562. doi:10.1017/S2045796018000227. PMC 7032752. PMID 29769159. Gilbert P (2007). Psychotherapy and counselling for depression (3rd ed.). Los Angeles: Sage. ISBN 978-1849203494. OCLC 436076587. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). American Psychiatric Association. 2013. Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (July 2008). "The link between childhood trauma and depression: insights from HPA axis studies in humans". Psychoneuroendocrinology. 33 (6): 693–710. doi:10.1016/j.psyneuen.2008.03.008. PMID 18602762. S2CID 2629673. Pillemer K, Suitor JJ, Pardo S, Henderson C (April 2010). "Mothers' Differentiation and Depressive Symptoms among Adult Children". Journal of Marriage and the Family. 72 (2): 333–345. doi:10.1111/j.1741-3737.2010.00703.x. PMC 2894713. PMID 20607119. Lindert J, von Ehrenstein OS, Grashow R, Gal G, Braehler E, Weisskopf MG (April 2014). "Sexual and physical abuse in childhood is associated with depression and anxiety over the life course: systematic review and meta-analysis". International Journal of Public Health. 59 (2): 359–72. doi:10.1007/s00038-013-0519-5. PMID 24122075. S2CID 24138761. Schmidt PJ (December 2005). "Mood, depression, and reproductive hormones in the menopausal transition". The American Journal of Medicine. 118 (12B): 54–8. doi:10.1016/j.amjmed.2005.09.033. PMID 16414327. Rashid T, Haider I (31 January 2008). "Life Events and Depression". Annals of Punjab Medical College. 2 (1): 11–16. ISSN 2077-9143. Archived from the original on 1 November 2020. Retrieved 18 February 2022. Mata DA, Ramos MA, Bansal N, Khan R, Guille C, Di Angelantonio E, Sen S (December 2015). "Prevalence of Depression and Depressive Symptoms Among Resident Physicians: A Systematic Review and Meta-analysis". JAMA. 314 (22): 2373–83. doi:10.1001/jama.2015.15845. PMC 4866499. PMID 26647259. "NIMH » Perinatal Depression". www.nimh.nih.gov. Archived from the original on 27 March 2020. Retrieved 29 October 2020. "Postpartum Depression". medlineplus.gov. Archived from the original on 27 July 2016. Retrieved 29 October 2020. Davey CG, Yücel M, Allen NB (2008). "The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward". Neuroscience and Biobehavioral Reviews. 32 (1): 1–19. doi:10.1016/j.neubiorev.2007.04.016. PMID 17570526. S2CID 20800688. "Journal of Psychiatric Research | ScienceDirect.com by Elsevier". www.sciencedirect.com. Archived from the original on 27 March 2018. Retrieved 7 April 2021. "COVID-19 pandemic severely impacts mental health of young people". ScienceDaily. Archived from the original on 23 March 2021. Retrieved 7 April 2021. Jeronimus BF, Kotov R, Riese H, Ormel J (October 2016). "Neuroticism's prospective association with mental disorders halves after adjustment for baseline symptoms and psychiatric history, but the adjusted association hardly decays with time: a meta-analysis on 59 longitudinal/prospective studies with 443 313 participants". Psychological Medicine. 46 (14): 2883–2906. doi:10.1017/S0033291716001653. PMID 27523506. S2CID 23548727. Archived from the original on 29 December 2019. Retrieved 5 July 2019. Kotov R, Gamez W, Schmidt F, Watson D (September 2010). "Linking "big" personality traits to anxiety, depressive, and substance use disorders: a meta-analysis". Psychological Bulletin. 136 (5): 768–821. doi:10.1037/a0020327. PMID 20804236. "Signs and Symptoms of Mild, Moderate, and Severe Depression". 27 March 2017. Archived from the original on 19 May 2017. Retrieved 10 March 2018. Gowin J (2010). "Your Brain on Alcohol". Psychology Today. Archived from the original on 18 February 2022. Retrieved 26 March 2019. "Alcohol and mental health". www.drinkaware.co.uk. Archived from the original on 17 July 2016. Retrieved 26 March 2019. Geisner IM, Mallett K, Varvil-Weld L, Ackerman S, Trager BM, Turrisi R (March 2018). "An examination of heavy drinking, depressed mood, drinking related constructs, and consequences among high-risk college students using a person-centered approach". Addictive Behaviors. 78: 22–29. doi:10.1016/j.addbeh.2017.10.022. PMC 5783735. PMID 29121529. Hoprekstad ØL, Hetland J, Bakker AB, Olsen OK, Espevik R, Wessel M, Einarsen SV (4 March 2019). "How long does it last? Prior victimization from workplace bullying moderates the relationship between daily exposure to negative acts and subsequent depressed mood". European Journal of Work and Organizational Psychology. 28 (2): 164–78. doi:10.1080/1359432X.2018.1564279. hdl:1956/22583. S2CID 149643302. Rogers D, Pies R (December 2008). "General medical with depression drugs associated". Psychiatry. 5 (12): 28–41. PMC 2729620. PMID 19724774. Botts S, Ryan M. Drug-Induced Diseases Section IV: Drug-Induced Psychiatric Diseases Chapter 18: Depression. pp. 1–23. Archived from the original on 23 December 2010. Retrieved 14 January 2017. American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders, fifth edition. Arlington, VA: American Psychiatric Association. Murray ED, Buttner N, Price BH. (2012) Depression and Psychosis in Neurological Practice. In: Neurology in Clinical Practice, 6th Edition. Bradley WG, Daroff RB, Fenichel GM, Jankovic J (eds.) Butterworth Heinemann ISBN 978-1437704341 Saravane D, Feve B, Frances Y, Corruble E, Lancon C, Chanson P, et al. (September 2009). "[Drawing up guidelines for the attendance of physical health of patients with severe mental illness]". L'Encéphale. 35 (4): 330–9. doi:10.1016/j.encep.2008.10.014. PMID 19748369. Rustad JK, Musselman DL, Nemeroff CB (October 2011). "The relationship of depression and diabetes: pathophysiological and treatment implications". Psychoneuroendocrinology. 36 (9): 1276–86. doi:10.1016/j.psyneuen.2011.03.005. PMID 21474250. S2CID 32439196. Li M, Fitzgerald P, Rodin G (April 2012). "Evidence-based treatment of depression in patients with cancer". Journal of Clinical Oncology. 30 (11): 1187–96. doi:10.1200/JCO.2011.39.7372. PMID 22412144. Gabbard G. Treatment of Psychiatric Disorders. Vol. 2 (3rd ed.). Washington, DC: American Psychiatric Publishing. p. 1296. American Psychiatric Association (2000a). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR. Washington, DC: American Psychiatric Publishing, Inc. ISBN 978-0890420256. Vieweg WV, Julius DA, Fernandez A, Beatty-Brooks M, Hettema JM, Pandurangi AK (May 2006). "Posttraumatic stress disorder: clinical features, pathophysiology, and treatment". The American Journal of Medicine. 119 (5): 383–90. doi:10.1016/j.amjmed.2005.09.027. PMID 16651048. Cvetkovich A (2012). Depression: A Public Feeling. Durham, NC: Duke University Press Books. ISBN 978-0822352389. Cox WT, Abramson LY, Devine PG, Hollon SD (September 2012). "Stereotypes, Prejudice, and Depression: The Integrated Perspective". Perspectives on Psychological Science. 7 (5): 427–49. doi:10.1177/1745691612455204. PMID 26168502. S2CID 1512121. Kroenke K, Spitzer RL, Williams JB (September 2001). "The PHQ-9: validity of a brief depression severity measure". Journal of General Internal Medicine. 16 (9): 606–13. doi:10.1046/j.1525-1497.2001.016009606.x. PMC 1495268. PMID 11556941. Warr P, Bindl UK, Parker SK, Inceoglu I (4 May 2014). "Four-quadrant investigation of job-related affects and behaviours" (PDF). European Journal of Work and Organizational Psychology. 23 (3): 342–63. doi:10.1080/1359432X.2012.744449. ISSN 1359-432X. S2CID 14816184. Archived (PDF) from the original on 21 January 2022. Retrieved 18 February 2022. Mélendez JC, Alfonso-Benlliure V, Mayordomo T (December 2018). "Idle minds are the devil's tools? Coping, depressed mood and divergent thinking in older adults". Aging & Mental Health. 22 (12): 1606–1613. doi:10.1080/13607863.2017.1387765. PMID 29052429. S2CID 12496617. Fradera A (2018). "Here's what the evidence shows about the links between creativity and depression". Research Digest. Archived from the original on 29 March 2019. Retrieved 26 March 2019. NICE guidelines, published October 2009 Archived 21 January 2021 at the Wayback Machine. Nice.org.uk. Retrieved on 2015-11-24. Schuch FB, Vancampfort D, Firth J, Rosenbaum S, Ward PB, Silva ES, et al. (July 2018). "Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies" (PDF). The American Journal of Psychiatry. 175 (7): 631–648. doi:10.1176/appi.ajp.2018.17111194. PMID 29690792. Archived (PDF) from the original on 24 July 2019. Retrieved 5 July 2019. Publishing, H. H. (n.d.). Exercise is an all-natural treatment to fight depression. Retrieved November 7, 2019, from Harvard Health website: https://www.health.harvard.edu/mind-and-mood/exercise-is-an-all-natural-treatment-to-fight-depression Archived 13 November 2019 at the Wayback Machine Cramer H, Lauche R, Langhorst J, Dobos G (November 2013). "Yoga for depression: a systematic review and meta-analysis". Depression and Anxiety. 30 (11): 1068–83. doi:10.1002/da.22166. PMID 23922209. S2CID 8892132. Grensman A, Acharya BD, Wändell P, Nilsson GH, Falkenberg T, Sundin Ö, Werner S (March 2018). "Effect of traditional yoga, mindfulness-based cognitive therapy, and cognitive behavioral therapy, on health related quality of life: a randomized controlled trial on patients on sick leave because of burnout". BMC Complementary and Alternative Medicine. 18 (1): 80. doi:10.1186/s12906-018-2141-9. PMC 5839058. PMID 29510704. Viguer P, Satorres E, Fortuna FB, Meléndez JC (November 2017). "A Follow-Up Study of a Reminiscence Intervention and Its Effects on Depressed Mood, Life Satisfaction, and Well-Being in the Elderly". The Journal of Psychology. 151 (8): 789–803. doi:10.1080/00223980.2017.1393379. PMID 29166223. S2CID 21839684. "Salivary Cortisol Levels and Depressive Symptomatology in Consumers and Nonconsumers of Self-Help Books: A Pilot Study". ResearchGate. Archived from the original on 18 February 2022. Retrieved 22 October 2020. Wilkinson P, Izmeth Z (September 2016). "Continuation and maintenance treatments for depression in older people". The Cochrane Database of Systematic Reviews. 2016 (9): CD006727. doi:10.1002/14651858.cd006727.pub3. PMC 6457610. PMID 27609183. Archived from the original on 18 February 2022. Retrieved 3 August 2021. "UN health agency reports depression now 'leading cause of disability worldwide'". UN News. 23 February 2017. Archived from the original on 27 June 2019. Retrieved 27 June 2019. Solomon A (17 November 2006). "Opinion | Our Great Depression". The New York Times. ISSN 0362-4331. Archived from the original on 27 June 2019. Retrieved 27 June 2019. Agence France-Presse (31 March 2017). "Depression is leading cause of disability worldwide, says WHO study". The Guardian. ISSN 0261-3077. Archived from the original on 27 June 2019. Retrieved 27 June 2019. Reynolds CF, Patel V (October 2017). "Screening for depression: the global mental health context". World Psychiatry. 16 (3): 316–317. doi:10.1002/wps.20459. PMC 5608832. PMID 28941110. Wang PS, Aguilar-Gaxiola S, Alonso J, Angermeyer MC, Borges G, Bromet EJ, et al. (September 2007). "Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys". Lancet. 370 (9590): 841–50. doi:10.1016/s0140-6736(07)61414-7. PMC 2847360. PMID 17826169. "Depression". www.who.int. Archived from the original on 26 December 2020. Retrieved 5 December 2019. "Stigma and Discrimination". www.psychiatry.org. Archived from the original on 1 May 2021. Retrieved 1 May 2021. Patel V, Weobong B, Nadkarni A, Weiss HA, Anand A, Naik S, et al. (April 2014). "The effectiveness and cost-effectiveness of lay counsellor-delivered psychological treatments for harmful and dependent drinking and moderate to severe depression in primary care in India: PREMIUM study protocol for randomized controlled trials". Trials. 15 (1): 101. doi:10.1186/1745-6215-15-101. PMC 4230277. PMID 24690184. depress. (n.d.). Online Etymology Dictionary. Retrieved June 30, 2008, from dictionary.com Wolpert, L. "Malignant Sadness: The Anatomy of Depression". The New York Times. Retrieved 30 October 2008. Liddell, Henry and Robert Scott (1980). A Greek-English Lexicon (Abridged ed.). United Kingdom: Oxford University Press. ISBN 0-19-910207-4. Hippocrates, Aphorisms, Section 6.23 Jackson SW (July 1983). "Melancholia and mechanical explanation in eighteenth-century medicine". Journal of the History of Medicine and Allied Sciences. 38 (3): 298–319. doi:10.1093/jhmas/38.3.298. PMID 6350428. Davison, K (2006). "Historical aspects of mood disorders". Psychiatry. 5 (4): 115–18. doi:10.1383/psyt.2006.5.4.115. A. Freeman; N. Epstein; KM Simon (1987), Depression in the family, New York: Haworth Press, pp. 64, 66 Frankl VE (2000). Man's search for ultimate meaning. New York, NY, USA: Basic Books. pp. 139–40. ISBN 0-7382-0354-8. Seidner, Stanley S. (June 10, 2009) "A Trojan Horse: Logotherapeutic Transcendence and its Secular Implications for Theology" Archived 1 May 2011 at the Wayback Machine. Mater Dei Institute. pp 14-15. Blair RG (October 2004). "Helping older adolescents search for meaning in depression". Journal of Mental Health Counseling. 26 (4): 333–347. doi:10.17744/mehc.26.4.w8u9h6uf5ybhapyl. Schildkraut, JJ (1965). "The catecholamine hypothesis of affective disorders: A review of supporting evidence". American Journal of Psychiatry. 122 (5): 509–22. doi:10.1176/ajp.122.5.509. PMID 5319766. Moncrieff, Joanna; Cooper, Ruth E.; Stockmann, Tom; Amendola, Simone; Hengartner, Michael P.; Horowitz, Mark A. (20 July 2022). "The serotonin theory of depression: a systematic umbrella review of the evidence". Molecular Psychiatry: 1–14. doi:10.1038/s41380-022-01661-0. ISSN 1476-5578. PMID 35854107. S2CID 250646781. Moncrieff, Joanna; Horowitz, Mark. "Depression is probably not caused by a chemical imbalance in the brain – new study". The Conversation. Retrieved 11 August 2022. "Study on serotonin and depression sparks fierce debate". France 24. 11 August 2022. Retrieved 11 August 2022. "Study on serotonin and depression sparks fierce debate". France 24. 11 August 2022. Retrieved 11 August 2022.External linksWikiquote has quotations related to Depression. Media related to Depression (mood) at Wikimedia CommonsClassification	DICD-10: F32.8MeSH: D003863DiseasesDB: 3589vteEmotions (list)Authority control: National libraries Edit this at Wikidata	UkraineGermanyCzech RepublicCategories: Depression (mood)EmotionsNeuropsychologyMental statesNavigation menuNot logged inTalkContributionsCreate accountLog inArticleTalkReadView sourceView historySearch WikipediaMain pageContentsCurrent eventsRandom articleAbout WikipediaContact usDonateContributeHelpLearn to editCommunity portalRecent changesUpload fileToolsWhat links hereRelated changesSpecial pagesPermanent linkPage informationCite this pageWikidata itemPrint/exportDownload as PDFPrintable versionIn other projectsWikimedia CommonsWikiquoteLanguagesDeutschEspañolFrançais한국어ItalianoРусскийTiếng Việtייִדיש中文75 moreEdit linksThis page was last edited on 12 December 2022, at 10:46 (UTC).Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.

# data[].attributes.subject
You know when Depression is a mental state of low mood and aversion to activity,[3] which affects more than 280 million people of all ages (about 3.5% of the global population).[4] Classified medically as a mental and behavioral disorder,[5] the experience of depression affects a person's thoughts, behavior, motivation, feelings, and sense of well-being.[6] The core symptom of depression is said to be anhedonia, which refers to loss of interest or a loss of feeling of pleasure in certain activities that usually bring joy to people.[7] Depressed mood is a symptom of some mood disorders such as major depressive disorder and dysthymia;[8] it is a normal temporary reaction to life events, such as the loss of a loved one; and it is also a symptom of some physical diseases and a side effect of some drugs and medical treatments. It may feature sadness, difficulty in thinking and concentration and a significant increase or decrease in appetite and time spent sleeping. People experiencing depression may have feelings of dejection, hopelessness and suicidal thoughts. It can either be short term or long term.Contents1	Factors1.1	Life events1.2	Personality1.3	Alcoholism1.4	Bullying1.5	Medical treatments1.6	Substance-induced1.7	Non-psychiatric illnesses1.8	Psychiatric syndromes1.9	Historical legacy2	Measures3	Creative thinking4	Theories5	Management6	Epidemiology7	History8	See also9	References10	External linksFactorsAllegory on melancholy, from circa 1729–40, etching and engraving, dimensions of the sheet: 42 × 25.7 cm, in the Metropolitan Museum of Art (New York City)Life eventsAdversity in childhood, such as bereavement, neglect, mental abuse, physical abuse, sexual abuse, or unequal parental treatment of siblings can contribute to depression in adulthood.[9][10] Childhood physical or sexual abuse in particular significantly correlates with the likelihood of experiencing depression over the survivor's lifetime.[11]Life events and changes that may influence depressed moods include (but are not limited to): childbirth, menopause, financial difficulties, unemployment, stress (such as from work, education, family, living conditions etc.), a medical diagnosis (cancer, HIV, etc.), bullying, loss of a loved one, natural disasters, social isolation, rape, relationship troubles, jealousy, separation, or catastrophic injury.[12][13][14][15][16] Adolescents may be especially prone to experiencing a depressed mood following social rejection, peer pressure, or bullying.[17]The global pandemic of COVID-19 has negatively impacted upon many individuals' mental health, causing levels of depression to surge, reaching devastating heights. A study conducted by the University of Surrey in autumn 2019 and May/June 2020 looked into the impact of COVID-19 upon young people's mental health. This study is published in the Journal of Psychiatry Research Report.[18] The study showed a significant rise in depression symptoms and a reduction in overall wellbeing during lockdown (May/June 2020) compared to the previous Autumn (2019). Levels of clinical depression in those surveyed in the study were found to have more than doubled, rising from 14.9 per cent in Autumn 2019 to 34.7 per cent in May/June 2020.[19] This study further emphasises the correlation that certain life events have with developing depression.PersonalityChanges in personality or in one's social environment can affect levels of depression. High scores on the personality domain neuroticism make the development of depressive symptoms as well as all kinds of depression diagnoses more likely,[20] and depression is associated with low extraversion.[21] Other personality indicators could be: temporary but rapid mood changes, short term hopelessness, loss of interest in activities that used to be of a part of one's life, sleep disruption, withdrawal from previous social life, appetite changes, and difficulty concentrating.[22]AlcoholismAlcohol can be a depressant which slows down some regions of the brain, like the prefrontal and temporal cortex, negatively affecting rationality and memory.[23] It also lowers the level of serotonin in the brain, which could potentially lead to higher chances of depressive mood.[24]The connection between the amount of alcohol intake, level of depressed mood, and how it affects the risks of experiencing consequences from alcoholism, were studied in a research done on college students. The study used 4 latent, distinct profiles of different alcohol intake and level of depression; Mild or Moderate Depression, and Heavy or Severe Drinkers. Other indicators consisting of social factors and individual behaviors were also taken into consideration in the research. Results showed that the level of depression as an emotion negatively affected the amount of risky behavior and consequence from drinking, while having an inverse relationship with protective behavioral strategies, which are behavioral actions taken by oneself for protection from the relative harm of alcohol intake. Having an elevated level of depressed mood does therefore lead to greater consequences from drinking.[25]BullyingSocial abuse, such as bullying, are defined as actions of singling out and causing harm on vulnerable individuals. In order to capture a day-to-day observation of the relationship between the damaging effects of social abuse, the survivor's mental health and depressive mood, a study was conducted on whether individuals would have a higher level of depressed mood when exposed to daily acts of negative behavior. The result concluded that being exposed daily to abusive behaviors such as bullying has a positive relationship to depressed mood on the same day.The study has also gone beyond to compare the level of depressive mood between the victims and non-victims of the daily bullying. Although victims were predicted to have a higher level of depressive mood, the results have shown otherwise that exposure to negative acts has led to similar levels of depressive mood, regardless of the victim status. The results therefore have concluded that bystanders and non-victims feel as equally depressed as the victim when being exposed to acts such as social abuse.[26]Medical treatmentsDepression may also be the result of healthcare, such as with medication induced depression. Therapies associated with depression include interferon therapy, beta-blockers, isotretinoin, contraceptives,[27] anticonvulsants, antimigraine drugs, antipsychotics, hormonal agents such as gonadotropin-releasing hormone agonist,[28] magnetic stimulation to brain and electric therapy.Substance-inducedSeveral drugs of abuse can cause or exacerbate depression, whether in intoxication, withdrawal, and from chronic use. These include alcohol, sedatives (including prescription benzodiazepines), opioids (including prescription pain killers and illicit drugs such as heroin), stimulants (such as cocaine and amphetamines), hallucinogens, and inhalants.[29]Non-psychiatric illnessesMain article: Depression (differential diagnoses)Depressed mood can be the result of a number of infectious diseases, nutritional deficiencies, neurological conditions,[30] and physiological problems, including hypoandrogenism (in men), addison's disease, cushing's syndrome, pernicious anemia, hypothyroidism, hyperparathyroidism, Lyme disease, multiple sclerosis, Parkinson's disease, chronic pain, stroke,[31] diabetes,[32] and cancer.[33]Psychiatric syndromesMain article: Depressive mood disordersA number of psychiatric syndromes feature depressed mood as a main symptom. The mood disorders are a group of disorders considered to be primary disturbances of mood. These include major depressive disorder (MDD; commonly called major depression or clinical depression) where a person has at least two weeks of depressed mood or a loss of interest or pleasure in nearly all activities; and dysthymia, a state of chronic depressed mood, the symptoms of which do not meet the severity of a major depressive episode. Another mood disorder, bipolar disorder, features one or more episodes of abnormally elevated mood, cognition, and energy levels, but may also involve one or more episodes of depression.[34] When the course of depressive episodes follows a seasonal pattern, the disorder (major depressive disorder, bipolar disorder, etc.) may be described as a seasonal affective disorder. Outside the mood disorders: borderline personality disorder often features an extremely intense depressive mood; adjustment disorder with depressed mood is a mood disturbance appearing as a psychological response to an identifiable event or stressor, in which the resulting emotional or behavioral symptoms are significant but do not meet the criteria for a major depressive episode;[35]: 355  and posttraumatic stress disorder, a mental disorder that sometimes follows trauma, is commonly accompanied by depressed mood.[36]Historical legacyMain article: Dispossession, oppression and depressionResearchers have begun to conceptualize ways in which the historical legacies of racism and colonialism may create depressive conditions.[37][38]MeasuresMeasures of depression as an emotional disorder include, but are not limited to: Beck Depression Inventory-11 and the 9-item depression scale in the Patient Health Questionnaire (PHQ-9).[39] Both of these measures are psychological tests that ask personal questions of the participant, and have mostly been used to measure the severity of depression. The Beck Depression Inventory (BDI) is a self-report scale that helps a therapist identify the patterns of depression symptoms and monitor recovery. The responses on this scale can be discussed in therapy to devise interventions for the most distressing symptoms of depression.[7] Several studies, however, have used these measures to also determine healthy individuals who are not experincing depression as a mental disorder, but as an occasional mood disorder. This is substantiated by the fact that depression as an emotional disorder displays similar symptoms to minimal depression and low levels of mental disorders such as major depressive disorder; therefore, researchers were able to use the same measure interchangeably. In terms of the scale, participants scoring between 0–13 and 0–4 respectively were considered healthy individuals.[25]Another measure of depressed mood would be the IWP Multi-affect Indicator.[40] It is a psychological test that indicates various emotions, such as enthusiasm and depression, and asks for the degree of the emotions that the participants have felt in the past week. There are studies that have used lesser items from the IWP Multi-affect Indicator which was then scaled down to daily levels to measure the daily levels of depression as an emotional disorder.[26]Creative thinkingDivergent thinking is defined as a thought process that generates creativity in ideas by exploring many possible solutions. Having a depressed mood will significantly reduce the possibility of divergent thinking, as it reduces the fluency, variety and the extent of originality of the possible ideas generated.[41]Some depressive mood disorders might have a positive effect for creativity. Upon identifying several studies and analyzing data involving individuals with high levels of creativity, Christa Taylor was able to conclude that there is a clear positive relationship between creativity and depressive mood. A possible reason is that having a low mood could lead to new ways of perceiving and learning from the world, but it is unable to account for certain depressive disorders. The direct relationship between creativity and depression remains unclear, but the research conducted on this correlation has shed light that individuals who are struggling with a depressive disorder may be having even higher levels of creativity than a control group, and would be a close topic to monitor depending on the future trends of how creativity will be perceived and demanded.[42]TheoriesSchools of depression theories include:Cognitive theory of depressionTripartite Model of Anxiety and DepressionBehavioral theories of depressionEvolutionary approaches to depressionBiology of depressionEpigenetics of depressionManagementMain article: Management of depressionDepressed mood may not require professional treatment, and may be a normal temporary reaction to life events, a symptom of some medical condition, or a side effect of some drugs or medical treatments. A prolonged depressed mood, especially in combination with other symptoms, may lead to a diagnosis of a psychiatric or medical condition which may benefit from treatment. The UK National Institute for Health and Care Excellence (NICE) 2009 guidelines indicate that antidepressants should not be routinely used for the initial treatment of mild depression, because the risk-benefit ratio is poor.[43] Physical activity can have a protective effect against the emergence of depression.[44]Physical activity can also decrease depressive symptoms due to the release of neurotrophic proteins in the brain that can help to rebuild the hippocampus that may be reduced due to depression.[45] Also yoga could be considered an ancillary treatment option for patients with depressive disorders and individuals with elevated levels of depression.[46][47]Reminiscence of old and fond memories is another alternative form of treatment, especially for the elderly who have lived longer and have more experiences in life. It is a method that causes a person to recollect memories of their own life, leading to a process of self-recognition and identifying familiar stimuli. By maintaining one's personal past and identity, it is a technique that stimulates people to view their lives in a more objective and balanced way, causing them to pay attention to positive information in their life stories, which would successfully reduce depressive mood levels.[48]Self-help books are a growing form of treatment for peoples physiological distress. There may be a possible connection between consumers of unguided self-help books and higher levels of stress and depressive symptoms. Researchers took many factors into consideration to find a difference in consumers and nonconsumers of self-help books. The study recruited 32 people between the ages of 18 and 65; 18 consumers and 14 nonconsumers, in both groups 75% of them were female. Then they broke the consumers into 11 who preferred problem-focused and 7 preferred growth-oriented. Those groups were tested for many things including cortisol levels, depressive symptomatology, and stress reactivity levels. There were no large differences between consumers of self-help books and nonconsumers when it comes to diurnal cortisol level, there was a large difference in depressive symptomatology (signs and symptoms) with consumers having a higher mean score. The growth-oriented group has higher stress reactivity levels than the problem-focused group. However, the problem-focused group shows higher depressive symptomatology.[49]There is limited evidence that continuing antidepressant medication for one year reduces the risk of depression recurrence with no additional harm.[50] Recommendations for psychological treatments or combination treatments in preventing recurrence are not clear.[50]There are empirical evidences of a connection between the type of stress management techniques and the level of daily depressive mood.[41]EpidemiologyMain article: Epidemiology of depressionDepression is the leading cause of disability worldwide, the United Nations (UN) health agency reported, estimating that it affects more than 300 million people worldwide – the majority of them women, young people and the elderly. An estimated 4.4 percent of the global population has depression, according to a report released by the UN World Health Organization (WHO), which shows an 18 percent increase in the number of people living with depression between 2005 and 2015.[51][52][53]Depression is a major mental-health cause of disease burden. Its consequences further lead to significant burden in public health, including a higher risk of dementia, premature mortality arising from physical disorders, and maternal depression impacts on child growth and development.[54] Approximately 76% to 85% of depressed people in low- and middle-income countries do not receive treatment;[55] barriers to treatment include: inaccurate assessment, lack of trained health-care providers, social stigma and lack of resources.[56]The stigma comes from misguided societal views that people with mental illness are different from everyone else, and they can choose to get better only if they wanted to.[57] Due to this more than half of the people with depression do not receive help with their disorders. The stigma leads to a strong preference for privacy.The World Health Organization has constructed guidelines – known as The Mental Health Gap Action Programme (mhGAP) – aiming to increase services for people with mental, neurological and substance-use disorders.[56] Depression is listed as one of conditions prioritized by the programme. Trials conducted show possibilities for the implementation of the programme in low-resource primary-care settings dependent on primary-care practitioners and lay health-workers.[58] Examples of mhGAP-endorsed therapies targeting depression include Group Interpersonal Therapy as group treatment for depression and "Thinking Health", which utilizes cognitive behavioral therapy to tackle perinatal depression.[56] Furthermore, effective screening in primary care is crucial for the access of treatments. The mhGAP adopted its approach of improving detection rates of depression by training general practitioners. However, there is still weak evidence supporting this training.[54]HistoryMain article: History of depressionThe term depression was derived from the Latin verb deprimere, "to press down".[59] From the 14th century, "to depress" meant to subjugate or to bring down in spirits. It was used in 1665 in English author Richard Baker's Chronicle to refer to someone having "a great depression of spirit", and by English author Samuel Johnson in a similar sense in 1753.[60]In Ancient Greece, disease was thought due to an imbalance in the four basic bodily fluids, or humors. Personality types were similarly thought to be determined by the dominant humor in a particular person. Derived from the Ancient Greek melas, "black", and kholé, "bile",[61] melancholia was described as a distinct disease with particular mental and physical symptoms by Hippocrates in his Aphorisms, where he characterized all "fears and despondencies, if they last a long time" as being symptomatic of the ailment.[62]During the 18th century, the humoral theory of melancholia was increasingly being challenged by mechanical and electrical explanations; references to dark and gloomy states gave way to ideas of slowed circulation and depleted energy.[63] German physician Johann Christian Heinroth, however, argued melancholia was a disturbance of the soul due to moral conflict within the patient.In the 20th century, the German psychiatrist Emil Kraepelin distinguished manic depression. The influential system put forward by Kraepelin unified nearly all types of mood disorder into manic–depressive insanity. Kraepelin worked from an assumption of underlying brain pathology, but also promoted a distinction between endogenous (internally caused) and exogenous (externally caused) types.[64] Around 1980, Kraepelin defined the term manic depression, which is also known as bipolar disorder. This mental health condition causes people to have mood swings, such as emotional highs and lows. Manic depression and bipolar disorder are considered the same thing because of these mood swings.[citation needed]Other psycho-dynamic theories were proposed. Existential and humanistic theories represented a forceful affirmation of individualism.[65] Austrian existential psychiatrist Viktor Frankl connected depression to feelings of futility and meaninglessness.[66] Frankl's logotherapy addressed the filling of an "existential vacuum" associated with such feelings, and may be particularly useful for depressed adolescents.[67][68]Researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms.[69] During the 1960s and 70s, manic-depression came to refer to just one type of mood disorder (now most commonly known as bipolar disorder) which was distinguished from (unipolar) depression. The terms unipolar and bipolar had been coined by German psychiatrist Karl Kleist.[64]In July 2022, British psychiatrist Joanna Moncrieff, also psychiatrist Mark Horowtiz and others proposed in a study on academic journal Molecular Psychiatry that depression is not caused by a serotonin imbalance in the human body, unlike what most of the psychiatry community points to, and that therefore anti-depressants don't work against the illness.[70][71] However, such study was met with criticism from some psychiatrists, who argued the study's methodology used an indirect trace of serotonin, instead of taking direct measurements of the molecule.[72] Moncrieff said that, despite her study's conclusions, no one should interrupt their treatment if they are taking any anti-depressant.[73]See alsoAttribution (psychology)Biopsychosocial modelDepression in childhood and adolescenceDiathesis–stress modelExistential crisisFeelingLocus of controlMelancholiaMixed anxiety–depressive disorderReferences "Depression". Cleveland Clinic. 2022. Retrieved 9 June 2022. Shrivastava A, Bureau Y, Rewari N, Johnston M (April 2013). "Clinical risk of stigma and discrimination of mental illnesses: Need for objective assessment and quantification". Indian Journal of Psychiatry. 55 (2): 178–82. doi:10.4103/0019-5545.111459. PMC 3696244. PMID 23825855. "NIMH » Depression Basics". www.nimh.nih.gov. 2016. Archived from the original on 11 June 2013. Retrieved 22 October 2020. "Depression". www.who.int. Archived from the original on 26 December 2020. Retrieved 7 April 2021. Sartorius N, Henderson AS, Strotzka H, Lipowski Z, Yu-cun S, You-xin X, et al. "The ICD-10 Classification of Mental and Behavioural Disorders Clinical descriptions and diagnostic guidelines" (PDF). www.who.int World Health Organization. pp. 30–1. Archived (PDF) from the original on 17 October 2004. Retrieved 23 June 2021. de Zwart PL, Jeronimus BF, de Jonge P (October 2019). "Empirical evidence for definitions of episode, remission, recovery, relapse and recurrence in depression: a systematic review". Epidemiology and Psychiatric Sciences. 28 (5): 544–562. doi:10.1017/S2045796018000227. PMC 7032752. PMID 29769159. Gilbert P (2007). Psychotherapy and counselling for depression (3rd ed.). Los Angeles: Sage. ISBN 978-1849203494. OCLC 436076587. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). American Psychiatric Association. 2013. Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (July 2008). "The link between childhood trauma and depression: insights from HPA axis studies in humans". Psychoneuroendocrinology. 33 (6): 693–710. doi:10.1016/j.psyneuen.2008.03.008. PMID 18602762. S2CID 2629673. Pillemer K, Suitor JJ, Pardo S, Henderson C (April 2010). "Mothers' Differentiation and Depressive Symptoms among Adult Children". Journal of Marriage and the Family. 72 (2): 333–345. doi:10.1111/j.1741-3737.2010.00703.x. PMC 2894713. PMID 20607119. Lindert J, von Ehrenstein OS, Grashow R, Gal G, Braehler E, Weisskopf MG (April 2014). "Sexual and physical abuse in childhood is associated with depression and anxiety over the life course: systematic review and meta-analysis". International Journal of Public Health. 59 (2): 359–72. doi:10.1007/s00038-013-0519-5. PMID 24122075. S2CID 24138761. Schmidt PJ (December 2005). "Mood, depression, and reproductive hormones in the menopausal transition". The American Journal of Medicine. 118 (12B): 54–8. doi:10.1016/j.amjmed.2005.09.033. PMID 16414327. Rashid T, Haider I (31 January 2008). "Life Events and Depression". Annals of Punjab Medical College. 2 (1): 11–16. ISSN 2077-9143. Archived from the original on 1 November 2020. Retrieved 18 February 2022. Mata DA, Ramos MA, Bansal N, Khan R, Guille C, Di Angelantonio E, Sen S (December 2015). "Prevalence of Depression and Depressive Symptoms Among Resident Physicians: A Systematic Review and Meta-analysis". JAMA. 314 (22): 2373–83. doi:10.1001/jama.2015.15845. PMC 4866499. PMID 26647259. "NIMH » Perinatal Depression". www.nimh.nih.gov. Archived from the original on 27 March 2020. Retrieved 29 October 2020. "Postpartum Depression". medlineplus.gov. Archived from the original on 27 July 2016. Retrieved 29 October 2020. Davey CG, Yücel M, Allen NB (2008). "The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward". Neuroscience and Biobehavioral Reviews. 32 (1): 1–19. doi:10.1016/j.neubiorev.2007.04.016. PMID 17570526. S2CID 20800688. "Journal of Psychiatric Research | ScienceDirect.com by Elsevier". www.sciencedirect.com. Archived from the original on 27 March 2018. Retrieved 7 April 2021. "COVID-19 pandemic severely impacts mental health of young people". ScienceDaily. Archived from the original on 23 March 2021. Retrieved 7 April 2021. Jeronimus BF, Kotov R, Riese H, Ormel J (October 2016). "Neuroticism's prospective association with mental disorders halves after adjustment for baseline symptoms and psychiatric history, but the adjusted association hardly decays with time: a meta-analysis on 59 longitudinal/prospective studies with 443 313 participants". Psychological Medicine. 46 (14): 2883–2906. doi:10.1017/S0033291716001653. PMID 27523506. S2CID 23548727. Archived from the original on 29 December 2019. Retrieved 5 July 2019. Kotov R, Gamez W, Schmidt F, Watson D (September 2010). "Linking "big" personality traits to anxiety, depressive, and substance use disorders: a meta-analysis". Psychological Bulletin. 136 (5): 768–821. doi:10.1037/a0020327. PMID 20804236. "Signs and Symptoms of Mild, Moderate, and Severe Depression". 27 March 2017. Archived from the original on 19 May 2017. Retrieved 10 March 2018. Gowin J (2010). "Your Brain on Alcohol". Psychology Today. Archived from the original on 18 February 2022. Retrieved 26 March 2019. "Alcohol and mental health". www.drinkaware.co.uk. Archived from the original on 17 July 2016. Retrieved 26 March 2019. Geisner IM, Mallett K, Varvil-Weld L, Ackerman S, Trager BM, Turrisi R (March 2018). "An examination of heavy drinking, depressed mood, drinking related constructs, and consequences among high-risk college students using a person-centered approach". Addictive Behaviors. 78: 22–29. doi:10.1016/j.addbeh.2017.10.022. PMC 5783735. PMID 29121529. Hoprekstad ØL, Hetland J, Bakker AB, Olsen OK, Espevik R, Wessel M, Einarsen SV (4 March 2019). "How long does it last? Prior victimization from workplace bullying moderates the relationship between daily exposure to negative acts and subsequent depressed mood". European Journal of Work and Organizational Psychology. 28 (2): 164–78. doi:10.1080/1359432X.2018.1564279. hdl:1956/22583. S2CID 149643302. Rogers D, Pies R (December 2008). "General medical with depression drugs associated". Psychiatry. 5 (12): 28–41. PMC 2729620. PMID 19724774. Botts S, Ryan M. Drug-Induced Diseases Section IV: Drug-Induced Psychiatric Diseases Chapter 18: Depression. pp. 1–23. Archived from the original on 23 December 2010. Retrieved 14 January 2017. American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders, fifth edition. Arlington, VA: American Psychiatric Association. Murray ED, Buttner N, Price BH. (2012) Depression and Psychosis in Neurological Practice. In: Neurology in Clinical Practice, 6th Edition. Bradley WG, Daroff RB, Fenichel GM, Jankovic J (eds.) Butterworth Heinemann ISBN 978-1437704341 Saravane D, Feve B, Frances Y, Corruble E, Lancon C, Chanson P, et al. (September 2009). "[Drawing up guidelines for the attendance of physical health of patients with severe mental illness]". L'Encéphale. 35 (4): 330–9. doi:10.1016/j.encep.2008.10.014. PMID 19748369. Rustad JK, Musselman DL, Nemeroff CB (October 2011). "The relationship of depression and diabetes: pathophysiological and treatment implications". Psychoneuroendocrinology. 36 (9): 1276–86. doi:10.1016/j.psyneuen.2011.03.005. PMID 21474250. S2CID 32439196. Li M, Fitzgerald P, Rodin G (April 2012). "Evidence-based treatment of depression in patients with cancer". Journal of Clinical Oncology. 30 (11): 1187–96. doi:10.1200/JCO.2011.39.7372. PMID 22412144. Gabbard G. Treatment of Psychiatric Disorders. Vol. 2 (3rd ed.). Washington, DC: American Psychiatric Publishing. p. 1296. American Psychiatric Association (2000a). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR. Washington, DC: American Psychiatric Publishing, Inc. ISBN 978-0890420256. Vieweg WV, Julius DA, Fernandez A, Beatty-Brooks M, Hettema JM, Pandurangi AK (May 2006). "Posttraumatic stress disorder: clinical features, pathophysiology, and treatment". The American Journal of Medicine. 119 (5): 383–90. doi:10.1016/j.amjmed.2005.09.027. PMID 16651048. Cvetkovich A (2012). Depression: A Public Feeling. Durham, NC: Duke University Press Books. ISBN 978-0822352389. Cox WT, Abramson LY, Devine PG, Hollon SD (September 2012). "Stereotypes, Prejudice, and Depression: The Integrated Perspective". Perspectives on Psychological Science. 7 (5): 427–49. doi:10.1177/1745691612455204. PMID 26168502. S2CID 1512121. Kroenke K, Spitzer RL, Williams JB (September 2001). "The PHQ-9: validity of a brief depression severity measure". Journal of General Internal Medicine. 16 (9): 606–13. doi:10.1046/j.1525-1497.2001.016009606.x. PMC 1495268. PMID 11556941. Warr P, Bindl UK, Parker SK, Inceoglu I (4 May 2014). "Four-quadrant investigation of job-related affects and behaviours" (PDF). European Journal of Work and Organizational Psychology. 23 (3): 342–63. doi:10.1080/1359432X.2012.744449. ISSN 1359-432X. S2CID 14816184. Archived (PDF) from the original on 21 January 2022. Retrieved 18 February 2022. Mélendez JC, Alfonso-Benlliure V, Mayordomo T (December 2018). "Idle minds are the devil's tools? Coping, depressed mood and divergent thinking in older adults". Aging & Mental Health. 22 (12): 1606–1613. doi:10.1080/13607863.2017.1387765. PMID 29052429. S2CID 12496617. Fradera A (2018). "Here's what the evidence shows about the links between creativity and depression". Research Digest. Archived from the original on 29 March 2019. Retrieved 26 March 2019. NICE guidelines, published October 2009 Archived 21 January 2021 at the Wayback Machine. Nice.org.uk. Retrieved on 2015-11-24. Schuch FB, Vancampfort D, Firth J, Rosenbaum S, Ward PB, Silva ES, et al. (July 2018). "Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies" (PDF). The American Journal of Psychiatry. 175 (7): 631–648. doi:10.1176/appi.ajp.2018.17111194. PMID 29690792. Archived (PDF) from the original on 24 July 2019. Retrieved 5 July 2019. Publishing, H. H. (n.d.). Exercise is an all-natural treatment to fight depression. Retrieved November 7, 2019, from Harvard Health website: https://www.health.harvard.edu/mind-and-mood/exercise-is-an-all-natural-treatment-to-fight-depression Archived 13 November 2019 at the Wayback Machine Cramer H, Lauche R, Langhorst J, Dobos G (November 2013). "Yoga for depression: a systematic review and meta-analysis". Depression and Anxiety. 30 (11): 1068–83. doi:10.1002/da.22166. PMID 23922209. S2CID 8892132. Grensman A, Acharya BD, Wändell P, Nilsson GH, Falkenberg T, Sundin Ö, Werner S (March 2018). "Effect of traditional yoga, mindfulness-based cognitive therapy, and cognitive behavioral therapy, on health related quality of life: a randomized controlled trial on patients on sick leave because of burnout". BMC Complementary and Alternative Medicine. 18 (1): 80. doi:10.1186/s12906-018-2141-9. PMC 5839058. PMID 29510704. Viguer P, Satorres E, Fortuna FB, Meléndez JC (November 2017). "A Follow-Up Study of a Reminiscence Intervention and Its Effects on Depressed Mood, Life Satisfaction, and Well-Being in the Elderly". The Journal of Psychology. 151 (8): 789–803. doi:10.1080/00223980.2017.1393379. PMID 29166223. S2CID 21839684. "Salivary Cortisol Levels and Depressive Symptomatology in Consumers and Nonconsumers of Self-Help Books: A Pilot Study". ResearchGate. Archived from the original on 18 February 2022. Retrieved 22 October 2020. Wilkinson P, Izmeth Z (September 2016). "Continuation and maintenance treatments for depression in older people". The Cochrane Database of Systematic Reviews. 2016 (9): CD006727. doi:10.1002/14651858.cd006727.pub3. PMC 6457610. PMID 27609183. Archived from the original on 18 February 2022. Retrieved 3 August 2021. "UN health agency reports depression now 'leading cause of disability worldwide'". UN News. 23 February 2017. Archived from the original on 27 June 2019. Retrieved 27 June 2019. Solomon A (17 November 2006). "Opinion | Our Great Depression". The New York Times. ISSN 0362-4331. Archived from the original on 27 June 2019. Retrieved 27 June 2019. Agence France-Presse (31 March 2017). "Depression is leading cause of disability worldwide, says WHO study". The Guardian. ISSN 0261-3077. Archived from the original on 27 June 2019. Retrieved 27 June 2019. Reynolds CF, Patel V (October 2017). "Screening for depression: the global mental health context". World Psychiatry. 16 (3): 316–317. doi:10.1002/wps.20459. PMC 5608832. PMID 28941110. Wang PS, Aguilar-Gaxiola S, Alonso J, Angermeyer MC, Borges G, Bromet EJ, et al. (September 2007). "Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys". Lancet. 370 (9590): 841–50. doi:10.1016/s0140-6736(07)61414-7. PMC 2847360. PMID 17826169. "Depression". www.who.int. Archived from the original on 26 December 2020. Retrieved 5 December 2019. "Stigma and Discrimination". www.psychiatry.org. Archived from the original on 1 May 2021. Retrieved 1 May 2021. Patel V, Weobong B, Nadkarni A, Weiss HA, Anand A, Naik S, et al. (April 2014). "The effectiveness and cost-effectiveness of lay counsellor-delivered psychological treatments for harmful and dependent drinking and moderate to severe depression in primary care in India: PREMIUM study protocol for randomized controlled trials". Trials. 15 (1): 101. doi:10.1186/1745-6215-15-101. PMC 4230277. PMID 24690184. depress. (n.d.). Online Etymology Dictionary. Retrieved June 30, 2008, from dictionary.com Wolpert, L. "Malignant Sadness: The Anatomy of Depression". The New York Times. Retrieved 30 October 2008. Liddell, Henry and Robert Scott (1980). A Greek-English Lexicon (Abridged ed.). United Kingdom: Oxford University Press. ISBN 0-19-910207-4. Hippocrates, Aphorisms, Section 6.23 Jackson SW (July 1983). "Melancholia and mechanical explanation in eighteenth-century medicine". Journal of the History of Medicine and Allied Sciences. 38 (3): 298–319. doi:10.1093/jhmas/38.3.298. PMID 6350428. Davison, K (2006). "Historical aspects of mood disorders". Psychiatry. 5 (4): 115–18. doi:10.1383/psyt.2006.5.4.115. A. Freeman; N. Epstein; KM Simon (1987), Depression in the family, New York: Haworth Press, pp. 64, 66 Frankl VE (2000). Man's search for ultimate meaning. New York, NY, USA: Basic Books. pp. 139–40. ISBN 0-7382-0354-8. Seidner, Stanley S. (June 10, 2009) "A Trojan Horse: Logotherapeutic Transcendence and its Secular Implications for Theology" Archived 1 May 2011 at the Wayback Machine. Mater Dei Institute. pp 14-15. Blair RG (October 2004). "Helping older adolescents search for meaning in depression". Journal of Mental Health Counseling. 26 (4): 333–347. doi:10.17744/mehc.26.4.w8u9h6uf5ybhapyl. Schildkraut, JJ (1965). "The catecholamine hypothesis of affective disorders: A review of supporting evidence". American Journal of Psychiatry. 122 (5): 509–22. doi:10.1176/ajp.122.5.509. PMID 5319766. Moncrieff, Joanna; Cooper, Ruth E.; Stockmann, Tom; Amendola, Simone; Hengartner, Michael P.; Horowitz, Mark A. (20 July 2022). "The serotonin theory of depression: a systematic umbrella review of the evidence". Molecular Psychiatry: 1–14. doi:10.1038/s41380-022-01661-0. ISSN 1476-5578. PMID 35854107. S2CID 250646781. Moncrieff, Joanna; Horowitz, Mark. "Depression is probably not caused by a chemical imbalance in the brain – new study". The Conversation. Retrieved 11 August 2022. "Study on serotonin and depression sparks fierce debate". France 24. 11 August 2022. Retrieved 11 August 2022. "Study on serotonin and depression sparks fierce debate". France 24. 11 August 2022. Retrieved 11 August 2022.External linksWikiquote has quotations related to Depression. Media related to Depression (mood) at Wikimedia CommonsClassification	DICD-10: F32.8MeSH: D003863DiseasesDB: 3589vteEmotions (list)Authority control: National libraries Edit this at Wikidata	UkraineGermanyCzech RepublicCategories: Depression (mood)EmotionsNeuropsychologyMental statesNavigation menuNot logged inTalkContributionsCreate accountLog inArticleTalkReadView sourceView historySearch WikipediaMain pageContentsCurrent eventsRandom articleAbout WikipediaContact usDonateContributeHelpLearn to editCommunity portalRecent changesUpload fileToolsWhat links hereRelated changesSpecial pagesPermanent linkPage informationCite this pageWikidata itemPrint/exportDownload as PDFPrintable versionIn other projectsWikimedia CommonsWikiquoteLanguagesDeutschEspañolFrançais한국어ItalianoРусскийTiếng Việtייִדיש中文75 moreEdit linksThis page was last edited on 12 December 2022, at 10:46 (UTC).Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.