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All of the tribes before the Europeans showed up had viruses that they were used to and could fight off. After the Europeans showed up there were several new viruses they couldn't fight and almost all died because they weren't used to them.

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Before the Europeans showed up, every tribe in SC believed in their religion and each tribe had their own culture. After the Europeans showed up they were introduced to Christianity and other Religions and were heavily influenced by European culture.

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Most tribes before the Europeans had a steady population. After the Europeans showed up, smallpox began to ravage the Native American tribes and entirely wiped out some tribes/