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Highly Radiosensitive Until Mature (varies through lifetime)

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Highly Radiosensitive Until Mature (varies through lifetime)

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Radiosensitivity Varies But All Somewhat Sensitive

# data[].attributes.subject
Radiosensitivity Varies But All Somewhat Sensitive

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directly proportional to their reproductive activity

# data[].attributes.subject
directly proportional to their reproductive activity

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high rate of reproducibility = more sensitive

low rate of reproducibility = less sensitive

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directly proportionate to metabolic activity

# data[].attributes.subject
directly proportionate to metabolic activity

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higher metabolic rate = more sensitive

lower metabolic rate = less sensitive

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directly proportionate to length of time cells are in reproductive stage (mitotic phase)

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directly proportionate to length of time cells are in reproductive stage (mitotic phase)

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longer time in reproductive phase = more sensitive

shorter time in reproductive phase = less sensitive

*another way of saying inverse to age*

*younger cells more sensitive as they are closer to reproductive phase than mature cells*

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inversely proportionate to degree of cellular differentiation

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inversely proportionate to degree of cellular differentiation

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simple cell = more sensitive

complex cell = less sensitive

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Very High

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Radiosensitivity is a function of the metabolic state of the cell receiving the exposure.

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Simple (undifferentiated)

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Low

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Adult: very low

Fetus: very high

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Spermatogonia: very high

Ova: moderate to high depending on age of person

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Complex (differentiated)

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MOST RADIOSENSITIVE

Reproductive Activity: None but continuously replenished

Cellular Differentiation: Complex (developed immune cells)

Dose it takes to effect: 0.25 Gy depresses numbers but 0.5 - 1 Gy drops blood count to 0

Recovery time: Slow

*mature but sensitive*

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Both Adult & Fetal: Complex (highly specialized)

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Spermatogonia: Simple

Ova: Simple

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2nd Most Sensitive of Blood Cells

Reproductive Activity: Replenished from marrow

Cellular Differentiation: Moderate

Dose it takes to effect: 0.25 Gy first effects seen

Recovery time: roughly 2 months

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High

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Low

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Both Adult and Fetal: Low

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Spermatogonia: High

Ova: Active in early development, low once older

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3rd Most Sensitive of Blood Cells

Reproductive Activity: Slow, takes time for stem cells

Cellular Differentiation: Moderate

Dose it takes to effect: 0.5 Gy decreases numbers, 1 to 10 Gy depletes cells

Recovery time: roughly 2 months for repopulation

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Short

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Long

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Adult: Close to none

Fetal: Long (into development)

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Spermatogonia: Short

Ova: Decrease with age until they don't divide

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Moderate to High

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Simple (undifferentiated)

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High

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Short

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1-2 Gy temporary damage

10 Gy+ necrosis

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roughly 50 Gy

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roughly 50+ Gy

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Both Spermatogonia & Ova:

roughly 0.1 Gy to reduce sperm count / cause menstrual irregularity

2 Gy causes temporary sterility

5+ Gy causes permanent sterility

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2-10 Gy for erythema

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Short since cells regenerate quickly

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if damage is to nucleus --> cell death

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May not recover, signals not delivered if damage is to dendrite or axon

Fetal cells are highly sensitive and can lead to congenital defects

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1-2 weeks for erythema damage

Slower/permanent damage from higher doses

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Least Sensitive of Blood Cells

Reproductive Activity: Mature RBC don't divide but replenished roughly every 120 days

Cellular Differentiation: Complex (highly differentiated)

Dose it takes to effect: 2+ Gy to see effects on marrow

Recovery time: Several months

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Catchy way to remember it!

Bloody - Blood cells (Hemopoietic)

Germs - Germ cells (Spermatogonia/Ova)

Eat - Epithelial cells

Skin - skin basilar cells

Muscle - muscle cells/tissue

Nerves - Nerve tissue (but fetal cells are higher on list)