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E. Coli produces a toxin during infection that causes severe and life threatening disease. E. Coli infection is a serious problem in children. Symptoms of E. Coli include fever and bloody diarrhea. In adults E. Coli causes milder symptoms and produce more typical gastrointestinal problems. Even with treatment E.Coli symptoms can progress and cause more serious problems such as kidney damage and multiple organ failure. Treatment for E. Coli depends on the severity of the disease and can be very complicated because killing the bacteria can release more toxin. No vaccine is available for E. Coli. E. Coli is believed to have first appeared after children ate undercooked hamburgers from a fast food chain. More recent outbreaks involved other meats and various produce that are generally eaten raw. Cooking temperature requirements have been modified to prevent E. Coli outbreaks. Hamburgers should be cooked well done with no pink. Also food products and hands should be washed well to reduce risk of contracting E. Coli.