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In the beginning of novel the reader is left in the dark, while the series begings with an explanation about the setting.

In order to give this explanation, the order of events differs between the series and the novel

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The series starts with Offred, Hannah and Luke trying to run away, whereas the novel starts with the situation in the Red Center

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In the novel and in the series, Offred analyses the Wall to see whether or not Luke or Moira are there.

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In the series, Offred reveals her real name, June, but she doesn't in the novel

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When Offred and Ofglen go shopping, both in the novel and in the series they decide to take the scenic route.

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In the series you see Offred and Ofglen walking by a group of children, but that doesn't happen in the novel.

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The eavesdropping of the conversation between the commander and his wife by the handmaid

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The eavesdropping of the conversation between the commander and his wife by the handmaid

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Offred makes curses in her thoughts quite a lot in the series, while she is fairly timid in the novel

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Janine has a bigger role in the series than in the novel 

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Janine has a bigger role in the series than in the novel 

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In both the novel and the series the Handmaids go everywhere in pairs.

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Janine's personality is different in the series

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The age of the characters

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The commander and his wife were much younger than described in the book

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In the novel, Offred is very formal when talking to Nick and Ofglen and she barely talks to Nick, but in the series she has a full conversation with Nick. She is still formal when talking to Ofglen.

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description of the room

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Use of sirens stood out to create a particular daunting atmosphere

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Use of sirens stood out to create a particular daunting atmosphere

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Comment in the following: What was different, what stood out in the series, what choices did the director make and with what effect, etc. etc. etc.!

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Comment in the following: What was different, what stood out in the series, what choices did the director make and with what effect, etc. etc. etc.!