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Date: March 3, 1820
In an effort to preserve the balance of power in Congress between slave and free states, the Missouri Compromise was passed in 1820 admitting Missouri as a slave state and Maine as a free state. In 1854, the Missouri Compromise was repealed by the Kansas-Nebraska Act.

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Date:  May 18, 1928
Created during the presidency of John Quincy Adams and enacted during the presidency of Andrew Jackson, it was labeled the "Tariff of Abominations" by its Southern detractors because of the effects it had on the Southern economy. It set a 38% tax on some imported goods and a 45% tax on certain imported raw materials.

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Date: 1828 -1833
Nullification crisis, in U.S. history, confrontation between the state of South Carolina and the federal government in 1832–33 over the former's attempt to declare null and void within the state the federal Tariffs of 1828 and 1832.

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Date: April 25, 1846 - February 2 1848
The Mexican-American War was a conflict between the United States and Mexico, fought from April 1846 to February 1848. It stemmed from the annexation of the Republic of Texas by the U.S. in 1845 and from a dispute over whether Texas ended at the Nueces River (the Mexican claim) or the Rio Grande (the U.S. claim).

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Date: August 8, 1846
Wilmot introduced legislation in the House that boldly declared, "neither slavery nor involuntary servitude shall ever exist" in lands won in the Mexican-American War.

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Date:  January 29, 1850
Senator Henry Clay introduced a series of resolutions on January 29, 1850, in an attempt to seek a compromise and avert a crisis between North and South. As part of the Compromise of 1850, the Fugitive Slave Act was amended and the slave trade in Washington, D.C., was abolished.

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Date:  June 5, 1851
Uncle Tom's Cabin; or, Life Among the Lowly began to appear in serial form in the Washington National Era, an abolitionist weekly. Harriet Beecher Stowe's anti-slavery story was published in forty installments over the next ten months.

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Date:  May 30, 1854
The Kansas-Nebraska Act repealed the Missouri Compromise, created two new territories, and allowed for popular sovereignty.

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Date: 1855 - 1861
a series of violent civil confrontations in Kansas Territory, United States, between 1854 and 1861 which emerged from a political and ideological debate over the legality of slavery in the proposed state of Kansas.

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Date: 1857
Dred Scott was an enslaved African American who had lived for a while in illinois and in the Wisconsin Territory, both of which banned slavery. Scott sued for his freedom, arguing that since he had lived in a free state and a free territory, he was a free man. In 1854, a federal court found against Scott, ruling that he was still a slave. Scott's lawyers appealed to the Supreme Court, which heard arguments in 1856 and delivered its decision the following year.

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Date: October 16, 1859 - October 18, 1859
John Brown's raid on Harpers Ferry was an effort by abolitionist John Brown, from October 16 to 18, 1859, to initiate a slave revolt in Southern states by taking over the United States arsenal at Harpers Ferry, Virginia. It has been called the dress rehearsal for or Tragic Prelude to the Civil War.

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Date: November 6, 1860
The 1860 United States presidential election was the 19th quadrennial presidential election. It was held on Tuesday, November 6, 1860. In a four-way contest, the Republican Party ticket of Abraham Lincoln and Hannibal Hamlin emerged triumphant.