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Staphylococcus aureus causes staph and is the leading cause of skin and soft tissue damage. All ages can get Staphylococcus aureus in an open wound. A prevention method of Staphylococcus aureus is to wash your hands regularly and keep all wounds covered until healed. Symptoms include pain in the skin, blisters, boils, or rashes on the skin, and fever or chills. The treatment is antibiotics like penicillin.