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Today, evening primrose oil dietary supplements are promoted for atopic dermatitis (a type of eczema), rheumatoid arthritis, premenstrual syndrome (PMS), breast pain, menopause symptoms, and other conditions.

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Evening primrose roots are best harvested in fall of their first year or early spring of their second year, before the tall stem begins to grow.

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It is found growing wild from Canada to Texas all year round.

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The Cherokee, Iroquois, Ojibwas, and Potawatomi were among several Native American tribes that used evening primrose

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Native Americans made poultices from the evening primrose plant for bruises and wounds and used its stem and leaf juices as topical remedies for skin inflammations. In other cases they would prepare it to eat as food.

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Flowers, leaves, roots, seeds.

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The Indigenous would used evening primrose for both food and for medicinal purposes. They ate the cooked greens when young, and made a tea for overfatness and hot root poultice for piles. The plant was also used for the treatment of gastrointestinal disorders, whooping cough, and asthma. It treats migraine, tonifies the female reproductive system, and gently stimulates the liver. It is slightly laxative, with a large amount of mucilage that can support treatment of indigestion.