# data[].attributes.body
Sitagliptin and Metformin HCI Extended Release

# data[].attributes.body
Janumet XR is a combination prescription drug with different drug classes that help lower blood sugar in type 2 diabetes patients.

Sitagliptin = Dipeptdl Peptidase - 4 Inhibitor

Metformin = Biguanides

# data[].attributes.body
Used with caution during breastfeeding

We don't know what sitagliptin does to breast milk or the long-term effects a breastfed infant may have. We do know that it was present in milk from rats.

The benefits of breastfeeding must be compared to the risks of the effects of the medication. Uncontrolled blood sugar is also a risk, insulin therapy may be necessary.

Unknown effects on the fetus, another alternative for controlling blood sugar should be discussed if diet and exercise aren't working.

# data[].attributes.body
Tablet form not slip, crushed, or chewed before swallowing

Once daily with a meal, preferably in the evening

# data[].attributes.body
Lower blood sugar for adults with type 2 diabetes

Accompanied by regular exercise and healthy diet changes.

DO NOT TAKE FOR DIABETES TYPE 1 as will cause hypoglycemia and possible coma

# data[].attributes.body
Diabetic ketoacidosis, type 1 diabetes

Acidemia, hypoxia, lactic acidosis, metabolic acidosis

Adrenal insufficiency

Renal failure, renal disease, renal impairment

Pancreatitis

Heart failure

Geriatric

Decreased liver function (alcoholism)

Anemia

Dehydration

PCOS and Pregnancy

# data[].attributes.body
Taken Orally

Adults and Geriatrics Maximum Dose

Sitagliptin 100mg/day

Metformin 2,000mg/day

2 tablets

Children, Infants, Neonates - Unknown Effects

# data[].attributes.body
Severe

Megaloblastic Anemia - abnormally large red blood cells

Lactic Acidosis - decreased pH in blood due to buildup of lactic acid

Pancreatitis - inflammation of the pancreas

Moderate

Peripheral edema - excess fluid accumulation in extremities

Hypoglycemia - low blood sugar

Metabolic Acidosis - too much acid in bodily fluids decreasing blood pH

Constipation

Mild

Flatulence - Gas

Dyspepsia - Indigestion

Anorexia - Appetite Loss

Vomiting

Headache

# data[].attributes.body
Distributed quickly into surrounding tissues and fluid but slow distribution to red blood cells and deep tissues.

Highest concentration in GI tract

Metformin bioavailability of 500 mg dose is 50-60% peak plasma levels at 2.5 hours, half-life in blood 17.6 hours, plasma half-life 6.2 hours

Sitagliptin bioavailability of 100mg dose is 87% Peak plasma levels in 1-4 hours with a terminal half-life of 10-12 hours

Lower/delayed absorption with food, high-fat meal heavily decreases absorption

Sitagliptin is more rapidly absorbed compared to metformin