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According to the National Survey on Drug Use and Health, more than 18 million people in the United States have tried MDMA at least once in their lifetime.

MDMA is predominantly used by males between the ages of 18 and 25. Most use typically begins at 21 years of age.

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“In 2002, a 20-year-old, a woman was brought to the emergency room after having taken multiple tablets of ecstasy and large quantities of water while dancing and drinking excessively during a party the night before. She did not report any symptoms upon returning home after the party. In the morning she was found unresponsive and foaming at the mouth although no seizures were reported. She had rapid and shallow breathing, a weak pulse, and did not respond to painful stimuli. The patient was otherwise healthy, with no medical or surgical history or significant family history. 12 hours after admission, she was found to have wide-complex tachycardia, which was followed by pulseless electrical activity. Resuscitation efforts were unsuccessful, and the patient expired.”

She died from hyponatremia: water overdose

Source: K. Kalanter-Zadeh, M.K. Nguyen, R. Chang, and I. Kurtz, “Fatal hyponatremia in a young woman after ecstasy ingestion”, Nature Clinical Practice Nephrology, 2 (2006): 283–288.

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MDMA has been shown to increase three brain chemicals:

Dopamine—causes a surge in euphoria and increased energy/activity

Norepinephrine—increases heart rate and blood pressure

Serotonin—affects mood, appetite, sleep, and other functions (also triggers sexual arousal)

A serious immediate effect is a heatstroke because MDMA can trigger convulsions or seizures and widespread blood clotting followed by collapse and coma.

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MDMA (3,4 methylenedioxymethamphetamine) is a synthetic (man-made) drug that causes both hallucinogenic and stimulant effect