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function of nucleus and RER

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510934/

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http://ajcn.nutrition.org/content/73/6/1113.1.full

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https://www.researchgate.net/publication/43534418_Endoplasmic_reticulum_stress_contributes_to_vitamin_E_succinate-induced_apoptosis_in_human_gastric_cancer_SGC-7901_cells

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http://annals.org/article.aspx?articleid=1789253

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ER dysfunction and different ways it affects dementias

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ER dysfunction and different ways it affects dementias

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http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2001.00623.x/full

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http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200700316/full

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https://www.sciencedaily.com/releases/2012/02/120203180905.htm

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ER stress / chronic inflammation / cell surface protein changes

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ER stress / chronic inflammation / cell surface protein changes

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http://www.jci.org/articles/view/25102#SEC7

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ER stress and link to insulin resistance / obesity / inflammation

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ER stress and link to insulin resistance / obesity / inflammation

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http://www.jci.org/articles/view/25102#SEC7

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http://www.thenaturalvet.net/Fats-and-Their-Relationship-to-Cell-Membrane-Function_ep_61.htmlhttp://www.thenaturalvet.net/Fats-and-Their-Relationship-to-Cell-Membrane-Function_ep_61.html

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https://www.hsph.harvard.edu/nutritionsource/antioxidants/https://www.hsph.harvard.edu/nutritionsource/antioxidants/

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Ca dysfunction causes cell distress / death

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Ca dysfunction causes cell distress / death

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https://www.ncbi.nlm.nih.gov/pubmed/23595672

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http://www.pnas.org/content/96/7/3342.short

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https://www.alzheimers.org.uk/site/scripts/documents_info.php?documentID=2211&pageNumber=9

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Study to say that multi vitamins had no effect on elderly men and cognition with 12yrs of taking them

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Study to say that multi vitamins had no effect on elderly men and cognition with 12yrs of taking them

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http://annals.org/article.aspx?articleid=1789253

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Dementia - an integrated view of everything NICE has said

Non-pharmacological interventions

If a person with dementia develops distressing non-cognitive symptoms or behaviour that challenges, offer an early assessment to identify factors that may influence the behaviour. Include:

physical health

depression

possible undetected pain or discomfort

side effects of medication

individual biography

psychosocial factors

physical environmental factors

behavioural and functional analysis in conjunction with carers and care workers.

For more information see the NICE pathway on depression.

Develop individual care plans, record in the notes and review regularly at a frequency agreed with carers and staff.

For comorbid agitation, consider interventions tailored to the person's preferences, skills and abilities.

Monitor response and adapt the care plan as needed.

Depending on availability, consider options including:1

aromatherapy

multisensory stimulation

therapeutic use of music and/or dancing

animal-assisted therapy

massage.

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https://www.alzheimers.org.uk/site/scripts/services_info.php?serviceID=180

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neurotransmitter inhibitors to treat the cognitive symptoms in dementias

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neurotransmitter inhibitors to treat the cognitive symptoms in dementias

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https://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor

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https://pathways.nice.org.uk/pathways/dementia#path=view%3A/pathways/dementia/dementia-interventions.xml&content=view-node%3Anodes-drugs-for-alzheimers-disease

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For Emily - the intro has a summary of what the ER does :) 

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For Emily - the intro has a summary of what the ER does :) 

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http://www.biochemj.org/content/417/3/651

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Calcium channel disruption and how it causes problems in the brain (ER regulates calcium leves)

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Calcium channel disruption and how it causes problems in the brain (ER regulates calcium leves)

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https://www.alzheimers.org.uk/site/scripts/documents_info.php?documentID=382&pageNumber=2

Because of low oxygen levels - which ?links to the mitochondria?

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http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol25_no4/dnb_vol25_no4_401.pdf

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Header pages and Helena's pages so far.  Have done my research(ish) but not powerpointed it yet.
Steph