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 IL-6 and TNF alpha, which induce the Acute Phase Response. They act on the endothelium making the blood vessels leaky in order for the immune cells to get to the site of inflammation-> rednes

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Chemotaxis draws neutrophils to the site of infection down a chemical gradient of chemokines and interleukins released by immune cells.

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Diapedesis occurs when the Neutrophil squee

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The pediatrician described Jason’s pharynx, uvula, and tonsils as swollen and red. What are the four

cardinal signs of inflammation,

and how does each relate to changes in the blood vessels and immune cells and molecules at a

site of inflammation?
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What is the mechanism by which the number of circulating white blood cells is increased?
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What is the mechanism by which fever is induced and what are its benefits in terms of combating

an infection?
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The exudate on Jason’s tonsils consisted primarily of neutrophils, and the cbc that was performed

indicated that the number of neutrophils in his circulation was increased. What role do neutrophils play in a bacterial infection? In the course of your answer explain

terms such as

adhesion molecules, diapedesis, chemotaxsis, opsonization, NETOSIS

and phagocytosis.
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Jason’s physician noted that Jason’s cervical lymph nodes were enlarged, a condition referred to

as lymphadenopathy. Describe the structure and function(s) of lymph nodes, and list the other

organs and tissues that comprise the lymphatic system.
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