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https://docs.google.com/document/d/1jU4ylxmjmCx5qe2KQQKnNw8GQ0N0co9P/edit

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- Le Nguyen Thien Han
- Pham Vu Hoang Phuong
- Le Thi Ngoc Tam
- Nguyen Tran Phuoc Thuan
- Nguyen Tuong Van

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https://alzres.biomedcentral.com/articles/10.1186/s13195-019-0492-1?fbclid=IwAR3V46iUkssEiyyeFfPwLKysFBSXMENk3S7vM8bz9E_Rdwpx0ILXsS9rniI#Sec12

RESEARCH TITTLE:
Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial

Comparision:

1. Aim:

To find out whether dose titration before escalating to donepezil 23 mg is preferred.

2. Specific objectives:

Three groups with different doses and usage duration.

“Patients were randomized into 3 groups according to the dose escalation method: 15 mg of donepezil for 4 weeks before escalating to 23 mg (group 1), 10 mg and 23 mg on alternate days for 4 weeks prior to escalation (group 2), and direct escalation to 23 mg (group 3)”

Specific target: patients with moderate to severe AD.

Sample size: 180 patients.

Specific statistic method (randomized, multicenter, open-label, parallel-group, three-arm prospective)

Pharmacokinetic analyses of drug concentration in plasma.

Correlation between age, sex, BMI, comorbidities.

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Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial - Alzheimer’s Research & Therapy

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Background High-dose donepezil is currently prescribed for patients with Alzheimer’s disease (AD) who showed poor or waning response to a lower dose at the risk of increasing cholinergic side effects. However, the adverse events (AEs) depending on the method of dose escalation have not been clarifie…

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Questions about Neurodegeneration disease (2)

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Questions about Neurodegeneration disease (2)

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First choice sub area: hereditary of Alzheimer disease

Relevant: students, low budget, lack of equipment, lack of information.

Second choice: treatment for Alzheimer disease

=>Suitable

What are clinical objectives in the treatment of AD?

Which drugs are most used for treatment of AD in HCM city?

Why do you choose Donepezil?

Evaluation of efficacy and adverse events of Donepezil in HCM city's Alzheimer patients

Revelant:

=> Survey, question list, statistic, data

=> Equipment: excel, minitab, sources on internet, word MS, supervisor who masters in Alzheimer disease field
=> Time: 6-9 months
=> Cost: suitable for students

Questions:
+ Do patients in HCM city using Donezepil have effects?

Vision: research in new drugs with better efficacy than Donezepil in AD treatment
+ Which structure affects on adverse events?
+ Which structure participate in increase effecacy and reduce adverse events?
+ Which structure can be changed for better efficacy?

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1. Definition:
- "Rigorous is careful to look at or consider every part of something to make certain it is correct or safe" - Cambrigde Dictionary.
- "Rigorous" describes a condition of strickness, best practices of the scientific method and applying those to the research.

- Rigorous in research is a way to establish confidence in the finding of research study or opions/arguments.

It also demonstrates the consistency/ accuracy in the method of research.

—> trustworthy evidence.

- Ex: "It is about determining the appropriate sample size for your study so that you have sufficient statistical power to be more confident about whether you are generating false positives or missing out on false negatives". - https://journals.asm.org/doi/10.1128/mBio.01902-16?fbclid=IwAR0ujqOKyptPFRaijTHy_pY_U4BW7Rg4NuhrQbUXFHnB-c0Aegv9pbiuZQA

2. Pros:

- Without the rigor, the result and the research will have low value and insufficient support

- Rigorous helps reduce the bias in research findings, data analysis and researcher's perspectives.

3. Scale of rigor in research:
- Purposfully misleading rigor
- Creative of crafty rigor
- Careless rigor
- Careful rigor
- Enduring rigor

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What is Neurodegeneration disease?

Symptoms of this disease.

Treatments for neurodegeneration disease.

How does Neurodegeneration disease affect the brain?

Correlation between neurodegeneration disease and sex, age, race.

Pathophysiology of neurodegeneration disease.

Impact of neurodegeneration disease on patient life.

Evaluate the effectiveness (biocompability, bioavailability…) of a specific drug on neurodegeneration disease.

Which approaches can be applied to treat this disease?

What factors cause neurodegeneration disease?

How to avoid neurodegeneration disease?

Which signs can be used to diagnose or anticipate as soon as possible?

Which signs can be used to diagnose or anticipate as soon as possible?

The recent status (the number of patients, how the government epidemology) of neurodegeneration disease in Asia/ Europe …