# data[].attributes.body
Interactive

# data[].attributes.attachment_link.readable_text
Continued From Above...

Nervous System Anatomy

Nervous Tissue

The majority of the nervous system is tissue made up of two classes of cells: neurons and neuroglia.

Neurons

Neurons, also known as nerve cells, communicate within the body by transmitting electrochemical signals. Neurons look quite different from other cells in the body due to the many long cellular processes that extend from their central cell body. The cell body is the roughly round part of a neuron that contains the nucleus, mitochondria, and most of the cellular organelles. Small tree-like structures called dendrites extend from the cell body to pick up stimuli from the environment, other neurons, or sensory receptor cells. Long transmitting processes called axons extend from the cell body to send signals onward to other neurons or effector cells in the body.

There are 3 basic classes of neurons: afferent neurons, efferent neurons, and interneurons.

1. Afferent neurons. Also known as sensory neurons, afferent neurons transmit sensory signals to the central nervous system from receptors in the body.

2. Efferent neurons. Also known as motor neurons, efferent neurons transmit signals from the central nervous system to effectors in the body such as muscles and glands.

3. Interneurons. Interneurons form complex networks within the central nervous system to integrate the information received from afferent neurons and to direct the function of the body through efferent neurons.

Neuroglia

Neuroglia, also known as glial cells, act as the "helper" cells of the nervous system. Each neuron in the body is surrounded by anywhere from 6 to 60 neuroglia that protect, feed, and insulate the neuron. Because neurons are extremely specialized cells that are essential to body function and almost never reproduce, neuroglia are vital to maintaining a functional nervous system.

Brain

The , a soft, wrinkled organ that weighs about 3 pounds, is located inside the cranial cavity, where the bones of the skull surround and protect it. The approximately 100 billion neurons of the brain form the main control center of the body. The brain and spinal cord together form the central nervous system (CNS), where information is processed and responses originate. The brain, the seat of higher mental functions such as consciousness, memory, planning, and voluntary actions, also controls lower body functions such as the maintenance of respiration, heart rate, blood pressure, and digestion.

Spinal Cord

The spinal cord is a long, thin mass of bundled neurons that carries information through the vertebral cavity of the spine beginning at the medulla oblongata of the brain on its superior end and continuing inferiorly to the lumbar region of the spine. In the lumbar region, the spinal cord separates into a bundle of individual nerves called the cauda equina (due to its resemblance to a horse's tail) that continues inferiorly to the and . The white matter of the spinal cord functions as the main conduit of nerve signals to the body from the brain. The grey matter of the spinal cord integrates reflexes to stimuli.

Nerves

Nerves are bundles of axons in the peripheral nervous system (PNS) that act as information highways to carry signals between the brain and spinal cord and the rest of the body. Each axon is wrapped in a connective tissue sheath called the endoneurium. Individual axons of the nerve are bundled into groups of axons called fascicles, wrapped in a sheath of connective tissue called the perineurium. Finally, many fascicles are wrapped together in another layer of connective tissue called the epineurium to form a whole nerve. The wrapping of nerves with connective tissue helps to protect the axons and to increase the speed of their communication within the body.

Afferent, Efferent, and Mixed Nerves. Some of the nerves in the body are specialized for carrying information in only one direction, similar to a one-way street. Nerves that carry information from sensory receptors to the central nervous system only are called afferent nerves. Other neurons, known as efferent nerves, carry signals only from the central nervous system to effectors such as muscles and glands. Finally, some nerves are mixed nerves that contain both afferent and efferent axons. Mixed nerves function like 2-way streets where afferent axons act as lanes heading toward the central nervous system and efferent axons act as lanes heading away from the central nervous system.

Cranial Nerves. Extending from the inferior side of the brain are 12 pairs of cranial nerves. Each cranial nerve pair is identified by a Roman numeral 1 to 12 based upon its location along the anterior-posterior axis of the brain. Each nerve also has a descriptive name (e.g. olfactory, optic, etc.) that identifies its function or location. The cranial nerves provide a direct connection to the brain for the special sense organs, muscles of the head, neck, and shoulders, the heart, and the GI tract.

Spinal Nerves. Extending from the left and right sides of the spinal cord are 31 pairs of spinal nerves. The spinal nerves are mixed nerves that carry both sensory and motor signals between the spinal cord and specific regions of the body. The 31 spinal nerves are split into 5 groups named for the 5 regions of the vertebral column. Thus, there are 8 pairs of cervical nerves, 12 pairs of thoracic nerves, 5 pairs of lumbar nerves, 5 pairs of sacral nerves, and 1 pair of coccygeal nerves. Each spinal nerve exits from the spinal cord through the intervertebral foramen between a pair of vertebrae or between the vertebra and the occipital bone of the skull.

Meninges

The meninges are the protective coverings of the central nervous system (CNS). They consist of three layers: the dura mater, arachnoid mater, and pia mater.

Dura mater. The , which means "tough mother," is the thickest, toughest, and most superficial layer of meninges. Made of dense irregular connective tissue, it contains many tough collagen fibers and blood vessels. Dura mater protects the CNS from external damage, contains the cerebrospinal fluid that surrounds the CNS, and provides blood to the nervous tissue of the CNS.

Arachnoid mater. The arachnoid mater, which means "spider-like mother," is much thinner and more delicate than the dura mater. It lines the inside of the dura mater and contains many thin fibers that connect it to the underlying pia mater. These fibers cross a fluid-filled space called the subarachnoid space between the arachnoid mater and the pia mater.

Pia mater. The , which means "tender mother," is a thin and delicate layer of tissue that rests on the outside of the brain and spinal cord. Containing many blood vessels that feed the nervous tissue of the CNS, the pia mater penetrates into the valleys of the sulci and fissures of the brain as it covers the entire surface of the CNS.

Cerebrospinal Fluid

The space surrounding the organs of the CNS is filled with a clear fluid known as cerebrospinal fluid (CSF). CSF is formed from blood plasma by special structures called choroid plexuses. The choroid plexuses contain many capillaries lined with epithelial tissue that filters blood plasma and allows the filtered fluid to enter the space around the brain.

Newly created CSF flows through the inside of the brain in hollow spaces called ventricles and through a small cavity in the middle of the spinal cord called the central canal. CSF also flows through the subarachnoid space around the outside of the brain and spinal cord. CSF is constantly produced at the choroid plexuses and is reabsorbed into the bloodstream at structures called arachnoid villi.

Cerebrospinal fluid provides several vital functions to the central nervous system:

1. CSF absorbs shocks between the brain and skull and between the spinal cord and vertebrae. This shock absorption protects the CNS from blows or sudden changes in velocity, such as during a car accident.

2. The brain and spinal cord float within the CSF, reducing their apparent weight through buoyancy. The brain is a very large but soft organ that requires a high volume of blood to function effectively. The reduced weight in cerebrospinal fluid allows the blood vessels of the brain to remain open and helps protect the nervous tissue from becoming crushed under its own weight.

3. CSF helps to maintain chemical homeostasis within the central nervous system. It contains ions, nutrients, oxygen, and albumins that support the chemical and osmotic balance of nervous tissue. CSF also removes waste products that form as byproducts of cellular metabolism within nervous tissue.

Sense Organs

All of the bodies' many sense organs are components of the nervous system. What are known as the special senses-vision, taste, smell, hearing, and balance-are all detected by specialized organs such as the , , and olfactory epithelium. Sensory receptors for the general senses like touch, temperature, and pain are found throughout most of the body. All of the sensory receptors of the body are connected to afferent neurons that carry their sensory information to the CNS to be processed and integrated.

Nervous System Physiology

Functions of the Nervous System

The nervous system has 3 main functions: sensory, integration, and motor.

1. Sensory. The sensory function of the nervous system involves collecting information from sensory receptors that monitor the body's internal and external conditions. These signals are then passed on to the central nervous system (CNS) for further processing by afferent neurons (and nerves).

2. Integration. The process of integration is the processing of the many sensory signals that are passed into the CNS at any given time. These signals are evaluated, compared, used for decision making, discarded or committed to memory as deemed appropriate. Integration takes place in the gray matter of the brain and spinal cord and is performed by interneurons. Many interneurons work together to form complex networks that provide this processing power.

3. Motor. Once the networks of interneurons in the CNS evaluate sensory information and decide on an action, they stimulate efferent neurons. Efferent neurons (also called motor neurons) carry signals from the gray matter of the CNS through the nerves of the peripheral nervous system to effector cells. The effector may be smooth, cardiac, or skeletal muscle tissue or glandular tissue. The effector then releases a hormone or moves a part of the body to respond to the stimulus.

Unfortunately of course, our nervous system doesn't always function as it should. Sometimes this is the result of diseases like Alzheimer's and Parkinson's disease. Did you know that DNA testing can help you discover your genetic risk of acquiring certain health conditions that affect the organs of our nervous system? Late-onset Alzheimer's, Parkinson's disease, macular degeneration - visit our guide to DNA health testing to find out more.

Divisions of the Nervous System

Central Nervous System

The brain and spinal cord together form the central nervous system, or CNS. The CNS acts as the control center of the body by providing its processing, memory, and regulation systems. The CNS takes in all of the conscious and subconscious sensory information from the body's sensory receptors to stay aware of the body's internal and external conditions. Using this sensory information, it makes decisions about both conscious and subconscious actions to take to maintain the body's homeostasis and ensure its survival. The CNS is also responsible for the higher functions of the nervous system such as language, creativity, expression, emotions, and personality. The brain is the seat of consciousness and determines who we are as individuals.

Peripheral Nervous System

The peripheral nervous system (PNS) includes all of the parts of the nervous system outside of the brain and spinal cord. These parts include all of the cranial and spinal nerves, ganglia, and sensory receptors.

Somatic Nervous System

The somatic nervous system (SNS) is a division of the PNS that includes all of the voluntary efferent neurons. The SNS is the only consciously controlled part of the PNS and is responsible for stimulating skeletal muscles in the body.

Autonomic Nervous System

The autonomic nervous system (ANS) is a division of the PNS that includes all of the involuntary efferent neurons. The ANS controls subconscious effectors such as visceral muscle tissue, cardiac muscle tissue, and glandular tissue.

There are 2 divisions of the autonomic nervous system in the body: the sympathetic and parasympathetic divisions.

Sympathetic. The sympathetic division forms the body's "fight or flight" response to stress, danger, excitement, exercise, emotions, and embarrassment. The sympathetic division increases respiration and heart rate, releases adrenaline and other stress hormones, and decreases digestion to cope with these situations.

Parasympathetic. The parasympathetic division forms the body's "rest and digest" response when the body is relaxed, resting, or feeding. The parasympathetic works to undo the work of the sympathetic division after a stressful situation. Among other functions, the parasympathetic division works to decrease respiration and heart rate, increase digestion, and permit the elimination of wastes.

Enteric Nervous System

The enteric nervous system (ENS) is the division of the ANS that is responsible for regulating digestion and the function of the digestive organs. The ENS receives signals from the central nervous system through both the sympathetic and parasympathetic divisions of the autonomic nervous system to help regulate its functions. However, the ENS mostly works independently of the CNS and continues to function without any outside input. For this reason, the ENS is often called the "brain of the gut" or the body's "second brain." The ENS is an immense system-almost as many neurons exist in the ENS as in the spinal cord.

Action Potentials

Neurons function through the generation and propagation of electrochemical signals known as action potentials (APs). An AP is created by the movement of sodium and potassium ions through the membrane of neurons. (See Water and Electrolytes.)

Resting Potential. At rest, neurons maintain a concentration of sodium ions outside of the cell and potassium ions inside of the cell. This concentration is maintained by the sodium-potassium pump of the cell membrane which pumps 3 sodium ions out of the cell for every 2 potassium ions that are pumped into the cell. The ion concentration results in a resting electrical potential of -70 millivolts (mV), which means that the inside of the cell has a negative charge compared to its surroundings.

Threshold Potential. If a stimulus permits enough positive ions to enter a region of the cell to cause it to reach -55 mV, that region of the cell will open its voltage-gated sodium channels and allow sodium ions to diffuse into the cell. -55 mV is the threshold potential for neurons as this is the "trigger" voltage that they must reach to cross the threshold into forming an action potential.

Depolarization. Sodium carries a positive charge that causes the cell to become depolarized (positively charged) compared to its normal negative charge. The voltage for depolarization of all neurons is +30 mV. The depolarization of the cell is the AP that is transmitted by the neuron as a nerve signal. The positive ions spread into neighboring regions of the cell, initiating a new AP in those regions as they reach -55 mV. The AP continues to spread down the cell membrane of the neuron until it reaches the end of an axon.

Repolarization. After the depolarization voltage of +30 mV is reached, voltage-gated potassium ion channels open, allowing positive potassium ions to diffuse out of the cell. The loss of potassium along with the pumping of sodium ions back out of the cell through the sodium-potassium pump restores the cell to the -55 mV resting potential. At this point the neuron is ready to start a new action potential.

Synapses

A synapse is the junction between a neuron and another cell. Synapses may form between 2 neurons or between a neuron and an effector cell. There are two types of synapses found in the body: chemical synapses and electrical synapses.

Chemical synapses. At the end of a neuron's axon is an enlarged region of the axon known as the axon terminal. The axon terminal is separated from the next cell by a small gap known as the synaptic cleft. When an AP reaches the axon terminal, it opens voltage-gated calcium ion channels. Calcium ions cause vesicles containing chemicals known as neurotransmitters (NT) to release their contents by exocytosis into the synaptic cleft. The NT molecules cross the synaptic cleft and bind to receptor molecules on the cell, forming a synapse with the neuron. These receptor molecules open ion channels that may either stimulate the receptor cell to form a new action potential or may inhibit the cell from forming an action potential when stimulated by another neuron.

Electrical synapses. Electrical synapses are formed when 2 neurons are connected by small holes called gap junctions. The gap junctions allow electric current to pass from one neuron to the other, so that an AP in one cell is passed directly on to the other cell through the synapse.

Myelination

The axons of many neurons are covered by a coating of insulation known as myelin to increase the speed of nerve conduction throughout the body. Myelin is formed by 2 types of glial cells: Schwann cells in the PNS and oligodendrocytes in the CNS. In both cases, the glial cells wrap their plasma membrane around the axon many times to form a thick covering of lipids. The development of these myelin sheaths is known as myelination.

Myelination speeds up the movement of APs in the axon by reducing the number of APs that must form for a signal to reach the end of an axon. The myelination process begins speeding up nerve conduction in fetal development and continues into early adulthood. Myelinated axons appear white due to the presence of lipids and form the white matter of the inner brain and outer spinal cord. White matter is specialized for carrying information quickly through the brain and spinal cord. The gray matter of the brain and spinal cord are the unmyelinated integration centers where information is processed.

Reflexes

Reflexes are fast, involuntary responses to stimuli. The most well known reflex is the patellar reflex, which is checked when a physicians taps on a patient's knee during a physical examination. Reflexes are integrated in the gray matter of the spinal cord or in the brain stem. Reflexes allow the body to respond to stimuli very quickly by sending responses to effectors before the nerve signals reach the conscious parts of the brain. This explains why people will often pull their hands away from a hot object before they realize they are in pain.

Functions of the Cranial Nerves

Each of the 12 cranial nerves has a specific function within the nervous system.

The olfactory nerve (I) carries scent information to the brain from the olfactory epithelium in the roof of the nasal cavity.

The optic nerve (II) carries visual information from the eyes to the brain.

Oculomotor, trochlear, and abducens nerves (III, IV, and VI) all work together to allow the brain to control the movement and focus of the eyes. The trigeminal nerve (V) carries sensations from the face and innervates the muscles of mastication.

The facial nerve (VII) innervates the muscles of the face to make facial expressions and carries taste information from the anterior 2/3 of the tongue.

The vestibulocochlear nerve (VIII) conducts auditory and balance information from the ears to the brain.

The glossopharyngeal nerve (IX) carries taste information from the posterior 1/3 of the tongue and assists in swallowing.

The vagus nerve (X), sometimes called the wandering nerve due to the fact that it innervates many different areas, "wanders" through the head, neck, and torso. It carries information about the condition of the vital organs to the brain, delivers motor signals to control speech and delivers parasympathetic signals to many organs.

The accessory nerve (XI) controls the movements of the shoulders and neck.

The hypoglossal nerve (XII) moves the tongue for speech and swallowing.

Sensory Physiology

All sensory receptors can be classified by their structure and by the type of stimulus that they detect. Structurally, there are 3 classes of sensory receptors: free nerve endings, encapsulated nerve endings, and specialized cells. Free nerve endings are simply free dendrites at the end of a neuron that extend into a tissue. Pain, heat, and cold are all sensed through free nerve endings. An encapsulated nerve ending is a free nerve ending wrapped in a round capsule of connective tissue. When the capsule is deformed by touch or pressure, the neuron is stimulated to send signals to the CNS. Specialized cells detect stimuli from the 5 special senses: vision, hearing, balance, smell, and taste. Each of the special senses has its own unique sensory cells-such as rods and cones in the retina to detect light for the sense of vision.

Functionally, there are 6 major classes of receptors: mechanoreceptors, nociceptors, photoreceptors, chemoreceptors, osmoreceptors, and thermoreceptors.

Mechanoreceptors. Mechanoreceptors are sensitive to mechanical stimuli like touch, pressure, vibration, and blood pressure.

Nociceptors. Nociceptors respond to stimuli such as extreme heat, cold, or tissue damage by sending pain signals to the CNS.

Photoreceptors. Photoreceptors in the retina detect light to provide the sense of vision.

Chemoreceptors. Chemoreceptors detect chemicals in the bloodstream and provide the senses of taste and smell.

Osmoreceptors. Osmoreceptors monitor the osmolarity of the blood to determine the body's hydration levels.

Thermoreceptors. Thermoreceptors detect temperatures inside the body and in its surroundings.

# data[].attributes.attachment_link.title
Nervous System: Explore the Nerves with Interactive Anatomy Pictures

# data[].attributes.attachment_link.description
Continued From Above... The majority of the nervous system is tissue made up of two classes of cells: neurons and neuroglia. Neurons Neurons, also known as nerve cells, communicate within the body by transmitting electrochemical signals. Neurons look quite different from other cells in the body due to the many long cellular processes that extend from their central cell body.

# data[].attributes.body
Khan Academy

# data[].attributes.attachment_link.description
If you're seeing this message, it means we're having trouble loading external resources for Khan Academy.

# data[].attributes.body
Web MD

# data[].attributes.attachment_link.readable_text
Your digestive system is uniquely designed to turn the food you eat into nutrients, which the body uses for energy, growth and cell repair. Here's how it works.

Mouth

The mouth is the beginning of the digestive tract. In fact, digestion starts here as soon as you take the first bite of a meal. Chewing breaks the food into pieces that are more easily digested, while saliva mixes with food to begin the process of breaking it down into a form your body can absorb and use.

Throat

Also called the pharynx, the throat is the next destination for food you've eaten. From here, food travels to the esophagus or swallowing tube.

Esophagus

The esophagus is a muscular tube extending from the pharynx to the stomach. By means of a series of contractions, called peristalsis, the esophagus delivers food to the stomach. Just before the connection to the stomach there is a "zone of high pressure," called the lower esophageal sphincter; this is a "valve" meant to keep food from passing backwards into the esophagus.

Stomach

The stomach is a sac-like organ with strong muscular walls. In addition to holding the food, it's also a mixer and grinder. The stomach secretes acid and powerful enzymes that continue the process of breaking down the food. When it leaves the stomach, food is the consistency of a liquid or paste. From there the food moves to the small intestine.

Small Intestine

Made up of three segments, the duodenum, jejunum, and ileum, the small intestine is a long tube loosely coiled in the abdomen (spread out, it would be more than 20 feet long). The small intestine continues the process of breaking down food by using enzymes released by the pancreas and bile from the liver. Bile is a compound that aids in the digestion of fat and eliminates waste products from the blood. Peristalsis (contractions) is also at work in this organ, moving food through and mixing it up with digestive secretions. The duodenum is largely responsible for continuing the process of breaking down food, with the jejunum and ileum being mainly responsible for the absorption of nutrients into the bloodstream.

# data[].attributes.attachment_link.description
Your digestive system is uniquely designed to turn the food you eat into nutrients, which the body uses for energy, growth and cell repair. Here's how it works. The mouth is the beginning of the digestive tract. In fact, digestion starts here as soon as you take the first bite of a meal.

# data[].attributes.body
Overview and Interactive

# data[].attributes.attachment_link.title
Urinary System: Anatomy and Physiology with Interactive Pictures

# data[].attributes.attachment_link.description
Learn about urinary system anatomy using interactive pictures supported by thorough descriptions of its function in the human body.

# data[].attributes.body
Khan Academy On Line Video

# data[].attributes.attachment_link.description
Welcome to the lymphatic system! Find out why we need it, and how it interacts with our blood vessels. By Patrick van Nieuwenhuizen.

# data[].attributes.body
Overview and Interactive

# data[].attributes.attachment_link.readable_text
Without muscle, humans could not live. The primary job of muscle is to move the bones of the skeleton, but muscles also enable the heart to beat and constitute the walls of other important hollow organs.

There are three types of muscle tissue:

Skeletal muscle: This type of muscle creates movement in the body. There are more than 600 skeletal muscles, and they makes up about 40 percent of a person's body weight. When the nervous system signals the muscle to contract, groups of muscles work together to move the skeleton. These signals and movements are nearly involuntary, yet they do require conscious effort. However, humans do not need to concentrate on individual muscles when moving.

Cardiac muscle: Cardiac muscle is involuntary muscle. This type makes up the walls of the heart and creates the steady, rhythmic pulsing that pumps blood through the body from signals from the brain. This muscle type also creates the electrical impulses that produce the heart's contractions, but hormones and stimuli from the nervous system can also affect these impulses, such as when your heart rate increases when you're scared.

Smooth muscle: Smooth muscle makes up the walls of hollow organs, respiratory passageways, and blood vessels. Its wavelike movements propel things through the bodily system, such as food through your stomach or urine through your bladder. Like cardiac muscle, smooth muscle is involuntary and also contracts in response to stimuli and nerve impulses.

Muscle movement happens when neurological signals produce electrical changes in muscle cells. During this process, calcium is released into the cells and brings about a short muscle twitch. Problems with the junction between the cells - called a synapse - can lead to neuromuscular diseases.

Muscle pain is a common issue that can signal numerous problems, even if it's something as simple as overuse. Some muscular disorders and conditions that affect muscles include:

Muscle pain

Sprains and strains

Bruising

Cramping

Myopathy

Muscular dystrophy

Parkinson's disease

Fibromyalgia

Multiple sclerosis

Proper nutrition and exercise is important to keeping all muscles healthy, whether they are cardiac, smooth, or skeletal.

# data[].attributes.attachment_link.title
Muscular System Anatomy, Diagram & Function | Healthline

# data[].attributes.attachment_link.description
Without muscle, humans could not live. The primary job of muscle is to move the bones of the skeleton, but muscles also enable the heart to beat and constitute the walls of other important hollow organs. There are three types of muscle tissue: Skeletal muscle: This type of muscle creates movement in the body.

# data[].attributes.body
Interactive Overview

# data[].attributes.attachment_link.readable_text
Continued From Above... act as the functional units of the respiratory system by passing oxygen into the body and carbon dioxide out of the body. Finally, the muscles of respiration, including the diaphragm and intercostal muscles, work together to act as a pump, pushing air into and out of the lungs during breathing.

Anatomy of the Respiratory System

Nose and Nasal Cavity

The nose and nasal cavity form the main external opening for the respiratory system and are the first section of the body's airway-the respiratory tract through which air moves. The nose is a structure of the face made of cartilage, bone, muscle, and skin that supports and protects the anterior portion of the nasal cavity. The nasal cavity is a hollow space within the nose and that is lined with hairs and mucus membrane. The function of the nasal cavity is to warm, moisturize, and filter air entering the body before it reaches the lungs. Hairs and mucus lining the nasal cavity help to trap dust, mold, pollen and other environmental contaminants before they can reach the inner portions of the body. Air exiting the body through the nose returns moisture and heat to the nasal cavity before being exhaled into the environment.

Mouth

The mouth, also known as the oral cavity, is the secondary external opening for the respiratory tract. Most normal breathing takes place through the nasal cavity, but the oral cavity can be used to supplement or replace the nasal cavity's functions when needed. Because the pathway of air entering the body from the mouth is shorter than the pathway for air entering from the nose, the mouth does not warm and moisturize the air entering the lungs as well as the nose performs this function. The mouth also lacks the hairs and sticky mucus that filter air passing through the nasal cavity. The one advantage of breathing through the mouth is that its shorter distance and larger diameter allows more air to quickly enter the body.

Pharynx

The pharynx, also known as the throat, is a muscular funnel that extends from the posterior end of the nasal cavity to the superior end of the and larynx. The pharynx is divided into 3 regions: the nasopharynx, oropharynx, and laryngopharynx. The nasopharynx is the superior region of the pharynx found in the posterior of the nasal cavity. Inhaled air from the nasal cavity passes into the nasopharynx and descends through the oropharynx, located in the posterior of the oral cavity. Air inhaled through the oral cavity enters the pharynx at the oropharynx. The inhaled air then descends into the laryngopharynx, where it is diverted into the opening of the larynx by the epiglottis. The epiglottis is a flap of elastic cartilage that acts as a switch between the trachea and the esophagus. Because the pharynx is also used to swallow food, the epiglottis ensures that air passes into the trachea by covering the opening to the esophagus. During the process of swallowing, the epiglottis moves to cover the trachea to ensure that food enters the esophagus and to prevent choking.

Larynx

The , also known as the voice box, is a short section of the airway that connects the laryngopharynx and the trachea. The larynx is located in the anterior portion of the neck, just inferior to the and superior to the trachea. Several cartilage structures make up the larynx and give it its structure. The epiglottis is one of the cartilage pieces of the larynx and serves as the cover of the larynx during swallowing. Inferior to the epiglottis is the thyroid cartilage, which is often referred to as the Adam's apple as it is most commonly enlarged and visible in adult males. The holds open the anterior end of the larynx and protects the vocal folds. Inferior to the thyroid cartilage is the ring-shaped cricoid cartilage which holds the larynx open and supports its posterior end. In addition to cartilage, the larynx contains special structures known as vocal folds, which allow the body to produce the sounds of speech and singing. The vocal folds are folds of mucous membrane that vibrate to produce vocal sounds. The tension and vibration speed of the vocal folds can be changed to change the pitch that they produce.

Trachea

The trachea, or windpipe, is a 5-inch long tube made of C-shaped hyaline cartilage rings lined with pseudostratified ciliated columnar epithelium. The trachea connects the larynx to the bronchi and allows air to pass through the neck and into the thorax. The rings of cartilage making up the trachea allow it to remain open to air at all times. The open end of the cartilage rings faces posteriorly toward the esophagus, allowing the esophagus to expand into the space occupied by the trachea to accommodate masses of food moving through the esophagus.

The main function of the trachea is to provide a clear airway for air to enter and exit the lungs. In addition, the epithelium lining the trachea produces mucus that traps dust and other contaminants and prevents it from reaching the lungs. Cilia on the surface of the epithelial cells move the mucus superiorly toward the pharynx where it can be swallowed and digested in the gastrointestinal tract.

Bronchi and Bronchioles

At the inferior end of the trachea, the airway splits into left and right branches known as the primary bronchi. The left and right bronchi run into each lung before branching off into smaller secondary bronchi. The secondary bronchi carry air into the lobes of the lungs-2 in the left lung and 3 in the right lung. The secondary bronchi in turn split into many smaller tertiary bronchi within each lobe. The tertiary bronchi split into many smaller bronchioles that spread throughout the lungs. Each bronchiole further splits into many smaller branches less than a millimeter in diameter called terminal bronchioles. Finally, the millions of tiny terminal bronchioles conduct air to the alveoli of the lungs.

As the airway splits into the tree-like branches of the bronchi and bronchioles, the structure of the walls of the airway begins to change. The primary bronchi contain many C-shaped cartilage rings that firmly hold the airway open and give the bronchi a cross-sectional shape like a flattened circle or a letter D. As the bronchi branch into secondary and tertiary bronchi, the cartilage becomes more widely spaced and more smooth muscle and elastin protein is found in the walls. The bronchioles differ from the structure of the bronchi in that they do not contain any cartilage at all. The presence of smooth muscles and elastin allow the smaller bronchi and bronchioles to be more flexible and contractile.

The main function of the bronchi and bronchioles is to carry air from the trachea into the lungs. Smooth muscle tissue in their walls helps to regulate airflow into the lungs. When greater volumes of air are required by the body, such as during exercise, the smooth muscle relaxes to dilate the bronchi and bronchioles. The dilated airway provides less resistance to airflow and allows more air to pass into and out of the lungs. The smooth muscle fibers are able to contract during rest to prevent hyperventilation. The bronchi and bronchioles also use the mucus and cilia of their epithelial lining to trap and move dust and other contaminants away from the lungs.

Lungs

The are a pair of large, spongy organs found in the thorax lateral to the and superior to the diaphragm. Each lung is surrounded by a pleural membrane that provides the lung with space to expand as well as a negative pressure space relative to the body's exterior. The negative pressure allows the lungs to passively fill with air as they relax. The left and right lungs are slightly different in size and shape due to the heart pointing to the left side of the body. The left lung is therefore slightly smaller than the right lung and is made up of 2 lobes while the right lung has 3 lobes.

The interior of the lungs is made up of spongy tissues containing many capillaries and around 30 million tiny sacs known as alveoli. The alveoli are cup-shaped structures found at the end of the terminal bronchioles and surrounded by capillaries. The alveoli are lined with thin simple squamous epithelium that allows air entering the alveoli to exchange its gases with the blood passing through the capillaries.

Muscles of Respiration

Surrounding the lungs are sets of muscles that are able to cause air to be inhaled or exhaled from the lungs. The principal muscle of respiration in the human body is the diaphragm, a thin sheet of skeletal muscle that forms the floor of the thorax. When the diaphragm contracts, it moves inferiorly a few inches into the abdominal cavity, expanding the space within the thoracic cavity and pulling air into the lungs. Relaxation of the diaphragm allows air to flow back out the lungs during exhalation.

Between the ribs are many small intercostal muscles that assist the diaphragm with expanding and compressing the lungs. These muscles are divided into 2 groups: the internal intercostal muscles and the external intercostal muscles. The internal intercostal muscles are the deeper set of muscles and depress the ribs to compress the thoracic cavity and force air to be exhaled from the lungs. The external intercostals are found superficial to the internal intercostals and function to elevate the ribs, expanding the volume of the thoracic cavity and causing air to be inhaled into the lungs.

Physiology of the Respiratory System

Pulmonary Ventilation

Pulmonary ventilation is the process of moving air into and out of the lungs to facilitate gas exchange. The respiratory system uses both a negative pressure system and the contraction of muscles to achieve pulmonary ventilation. The negative pressure system of the respiratory system involves the establishment of a negative pressure gradient between the alveoli and the external atmosphere. The pleural membrane seals the lungs and maintains the lungs at a pressure slightly below that of the atmosphere when the lungs are at rest. This results in air following the pressure gradient and passively filling the lungs at rest. As the lungs fill with air, the pressure within the lungs rises until it matches the atmospheric pressure. At this point, more air can be inhaled by the contraction of the diaphragm and the external intercostal muscles, increasing the volume of the thorax and reducing the pressure of the lungs below that of the atmosphere again.

To exhale air, the diaphragm and external intercostal muscles relax while the internal intercostal muscles contract to reduce the volume of the thorax and increase the pressure within the thoracic cavity. The pressure gradient is now reversed, resulting in the exhalation of air until the pressures inside the lungs and outside of the body are equal. At this point, the elastic nature of the lungs causes them to recoil back to their resting volume, restoring the negative pressure gradient present during inhalation.

External Respiration

External respiration is the exchange of gases between the air filling the alveoli and the blood in the capillaries surrounding the walls of the alveoli. Air entering the lungs from the atmosphere has a higher partial pressure of oxygen and a lower partial pressure of carbon dioxide than does the blood in the capillaries. The difference in partial pressures causes the gases to diffuse passively along their pressure gradients from high to low pressure through the simple squamous epithelium lining of the alveoli. The net result of external respiration is the movement of oxygen from the air into the blood and the movement of carbon dioxide from the blood into the air. The oxygen can then be transported to the body's tissues while carbon dioxide is released into the atmosphere during exhalation.

Internal Respiration

Internal respiration is the exchange of gases between the blood in capillaries and the tissues of the body. Capillary blood has a higher partial pressure of oxygen and a lower partial pressure of carbon dioxide than the tissues through which it passes. The difference in partial pressures leads to the diffusion of gases along their pressure gradients from high to low pressure through the endothelium lining of the capillaries. The net result of internal respiration is the diffusion of oxygen into the tissues and the diffusion of carbon dioxide into the blood.

Transportation of Gases

The 2 major respiratory gases, oxygen and carbon dioxide, are transported through the body in the blood. Blood plasma has the ability to transport some dissolved oxygen and carbon dioxide, but most of the gases transported in the blood are bonded to transport molecules. Hemoglobin is an important transport molecule found in red blood cells that carries almost 99% of the oxygen in the blood. Hemoglobin can also carry a small amount of carbon dioxide from the tissues back to the lungs. However, the vast majority of carbon dioxide is carried in the plasma as bicarbonate ion. When the partial pressure of carbon dioxide is high in the tissues, the enzyme carbonic anhydrase catalyzes a reaction between carbon dioxide and water to form carbonic acid. Carbonic acid then dissociates into hydrogen ion and bicarbonate ion. When the partial pressure of carbon dioxide is low in the lungs, the reactions reverse and carbon dioxide is liberated into the lungs to be exhaled.

Homeostatic Control of Respiration

Under normal resting conditions, the body maintains a quiet breathing rate and depth called eupnea. Eupnea is maintained until the body's demand for oxygen and production of carbon dioxide rises due to greater exertion. Autonomic chemoreceptors in the body monitor the partial pressures of oxygen and carbon dioxide in the blood and send signals to the respiratory center of the brain stem. The respiratory center then adjusts the rate and depth of breathing to return the blood to its normal levels of gas partial pressures.

Health Issues Affecting the Respiratory System

When something impairs our ability to exchange carbon dioxide for oxygen, this is obviously a serious problem. Many health problems can cause respiratory problems, from allergies and asthma to pneumonia and lung cancer. The causes of these issues are just as varied-among them, infection (bacterial or viral), environmental exposure (pollution or cigarette smoke, for instance), genetic inheritance or a combination of factors. Sometimes the onset is so gradual, we don't seek medical attention until the condition has advanced. Sometimes, as with the genetic disorder called alpha-1 antitrypsin deficiency (A1AD), symptoms gradually set in and are often under-diagnosed or misdiagnosed. DNA health testing can screen you for genetic risk of A1AD.

# data[].attributes.attachment_link.title
Respiratory System | Interactive Anatomy Guide

# data[].attributes.attachment_link.description
Continued From Above... act as the functional units of the respiratory system by passing oxygen into the body and carbon dioxide out of the body. Finally, the muscles of respiration, including the diaphragm and intercostal muscles, work together to act as a pump, pushing air into and out of the lungs during breathing.

# data[].attributes.body
2D and 3D Models

# data[].attributes.attachment_link.description
Skin is one of the most important organs in the human body. Our anatomy pictures and descriptions of the integumentary system will show you why.

# data[].attributes.body
Overview and Interactive

# data[].attributes.attachment_link.title
The Endocrine System | Hormone Health Network

# data[].attributes.attachment_link.description
What is the endocrine system and what is it's function? The experts at Hormone Health Network are here to answer all your hormone questions! Visit hormone.org today.

# data[].attributes.body
On line video

# data[].attributes.attachment_link.authors[].name
AboutKidsHealth - The Hospital for Sick Children

# data[].attributes.attachment_link.title
Exploring the Heart - The Circulatory System! | AboutKidsHealth at The Hospital for Sick Children

# data[].attributes.body
Centers for Disease Control

# data[].attributes.body
Quizlet.com Flash Cards

# data[].attributes.attachment_link.title
12 systems of the body, what’s their function? Flashcards | Quizlet

# data[].attributes.attachment_link.description
Start studying 12 systems of the body, what’s their function?. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

# data[].attributes.body
Video