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As well as negatively impacting the adult sleep cycle, using screens can also affect one's physical health. Obesity is a common result of spending great amounts on screens like a television, video games, or a computer screen. Studies have shown that if the amount of screen time adolescents spend was limited, the likelihood of obesity can be reduced.

This sedentary behavior is largely due to the nature of most electronic activities. Sitting to watch television, playing computer games or surfing the Internet takes time away from physical activities which leads to an increased risk of weight gain. It has been found that children (kindergarten and 1st graders) who watch 1–2 hours of television a day are more likely to be overweight or obese than children who watch less than one hour a day. Additionally, one study showed that the increased use of video games and other forms of media consumption led to more back pain among Norwegian teens.

It has been reported that screen time negatively affects health in children independently of their physical activity and eating habits. One possible explanation for the link between TV and obesity is the amount of commercials for sugary and unhealthy foods. This advertising can have an effect on what gets purchased and consumed in a household. The effect of advertising was demonstrated in a study where children were shown cartoons with and without food commercials. The children who watched the food commercials along with the cartoons ate 45% more unhealthy snacks than the group who watched the cartoons without food ads.

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As previously discussed, sleep and screen time are heavily impacted by the other and can lead to affecting one's behavior as well. If someone does not get an adequate amount of sleep, it can affect their behavior and performance for the day. High amounts of screen time also can significantly affect a person's mental health. With screen usage increasing as time progresses, adults have begun spending more and more time focusing their attention of screens. This time spent sitting and viewing a screen has been linked to mental health effects such as anxiety and depression. Adults who spend six hours or greater using screen time are more likely to suffer from moderate to severe depression.

This increased use in screen time has been shown to be directly correlated with an increased chance of depression in adults. With this added risk, lack of sleep plays a major role in a healthy mindset, and without proper rest, mental health can degrade at a higher rate.

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More screen-time has been linked with shorter sleep duration, decreased sleep efficiency, and longer sleep onset delay. When using any screen before bedtime, the blue light emitted disrupts the body's natural melatonin hormone production.

Melatonin is produced by the brain's pineal gland and controls the body's internal clock. This clock is what is referred to as the body's circadian rhythm and it naturally is responsive to light. Melatonin levels increase as the sun sets and remain at that increased state for the remainder of the night. As the sun rises, melatonin levels start to drop. This hormone reduction is what helps the body's natural rhythm wake up due to the bursts of natural sunlight. The light screens emit are in a similar spectrum of sunlight, but the blue light emission is what human circadian rhythms are most sensitive to. Studies have shown that the blue wavelengths are closely correlated to those from sunlight, which is what helps the body keep in sync with the sunrise and sunset. Therefore, using any screen prior to bedtime disrupts the body's production of natural bedtime hormones which can trick the brain to believe it is still daytime making it harder to fall asleep.