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Type- Gene Base
Gene- HEXA
Protein Affected

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Other forms of Tay-Sachs disease are very rare. Signs and symptoms can appear in childhood, adolescence, or adulthood and are usually milder than those seen with the infantile form.

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Tay-Sachs disease is a rare inherited disorder that progressively destroys nerve cells neurons in the brain and spinal cord

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frequencyTay-Sachs disease is very rare in the general population. The genetic mutations that cause this disease are more common in people of Ashkenazi (eastern and central European) Jewish heritage than in those with other backgrounds. The mutations responsible for this disease are also more common in certain French-Canadian communities of Quebec, the Old Order Amish community in Pennsylvania, and the Cajun population of Louisiana.

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frequencyTay-Sachs disease is very rare in the general population. The genetic mutations that cause this disease are more common in people of Ashkenazi (eastern and central European) Jewish heritage than in those with other backgrounds. The mutations responsible for this disease are also more common in certain French-Canadian communities of Quebec, the Old Order Amish community in Pennsylvania, and the Cajun population of Louisiana.

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The HEXA gene provides instructions for making one part (subunit) of an enzyme called beta-hexosaminidase A. Specifically, the protein produced from the HEXA gene forms the alpha subunit of thisenzyme. One alpha subunit joins with one betasubunit (produced from the HEXB gene) to form a functioning enzyme.

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https://www.dailylocal.com/news/national/irish-ancestry-focus-of-tay-sachs-families/article_e01ba0d2-3f50-5a60-a699-bbe5a3e63ba6.html