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1) When nicotine is brought to the brain, what chemicals are released? What does this cause?

Dopamine and endorphins causing smoking to be highly addictive

2) One in every ___3___ cancer deaths is caused by smoking.

3) What diseases can smoking contribute to?

3) List something that will improve a year after a smoker quits.

Heart rate and blood pressure return to normal.

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Krishna Sudhir: How do cigarettes affect the body?

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Cigarettes aren't good for us. That's hardly news -- we've known about the dangers of smoking for decades. But how exactly do cigarettes harm us, and can our bodies recover if we stop? Krishna Sudhir details what happens when we smoke -- and when we quit. [TED-Ed Animation by TED-Ed].

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What are vaping devices?

Vaping devices, also known as e-cigarettes, e-vaporizers, or electronic nicotine delivery systems, are battery-operated devices that people use to inhale an aerosol, which typically contains nicotine (though not always), flavorings, and other chemicals. They can resemble traditional tobacco cigarettes (cig-a-likes), cigars, or pipes, or even everyday items like pens or USB memory sticks. Other devices, such as those with fillable tanks, may look different. Regardless of their design and appearance, these devices generally operate in a similar manner and are made of similar components. More than 460 different e-cigarette brands are currently on the market. Some common nicknames for e-cigarettes are:

e-cigs

e-hookahs

hookah pens

vapes

vape pens

mods (customizable, more powerful vaporizers)

How do vaping devices work?

Most e-cigarettes consist of four different components, including:

a cartridge or reservoir or pod, which holds a liquid solution (e-liquid or e-juice) containing varying amounts of nicotine, flavorings, and other chemicals

a heating element (atomizer)

a power source (usually a battery)

a mouthpiece that the person uses to inhale

In many e-cigarettes, puffing activates the battery-powered heating device, which vaporizes the liquid in the cartridge. The person then inhales the resulting aerosol or vapor (called vaping).

Vaping Among Teens

Vaping devices are popular among teens and are now the most commonly used form of nicotine among youth in the United States. Some research shows that many teens do not even realize that vaping cartridges contain nicotine, and assume the pods contain only flavoring. The easy availability of these devices, alluring advertisements, various e-liquid flavors, and the belief that they're safer than cigarettes have helped make them appealing to this age group. In addition, they are easy to hide from teachers and parents because they do not leave behind the stench of tobacco cigarettes, and are often disguised as flash drives. Further, a study of high school students found that one in four teens reported using e-cigarettes for dripping, a practice in which people produce and inhale vapors by placing e-liquid drops directly onto heated atomizer coils. Teens reported the following reasons for dripping: to create thicker vapor (63.5 percent), to improve flavors (38.7 percent), and to produce a stronger throat hit-a pleasurable feeling that the vapor creates when it causes the throat to contract (27.7 percent). More research is needed on the risks of this practice.

In addition to the unknown health effects, early evidence suggests that vaping might serve as an introductory product for preteens and teens who then go on to use other nicotine products, including cigarettes, which are known to cause disease and premature death. A study showed that students who had used e-cigarettes by the time they started 9th grade were more likely than others to start smoking cigarettes and other smokable tobacco products within the next year. Another study supports these findings, showing that high school students who used e-cigarettes in the last month were about 7 times more likely to report that they smoked cigarettes when asked approximately 6 months later, as compared to students who said they didn't use e-cigarettes. Notably, the reverse was not true-students who said they smoked cigarettes were no more likely to report use of e-cigarettes when asked approximately 6 months later. Like the previous study, these results suggest that teens using e-cigarettes are at a greater risk for smoking cigarettes in the future. Another study has shown an association between e-cigarette smoking and progression to smoking actual cigarettes. This study suggests that vaping nicotine might actually encourage cigarette smoking in adolescents.

Additionally, a study of adult smokers in Europe found those who vaped nicotine were less like to have stopped smoking than those who did not. Those who used e-cigarettes also smoked more cigarettes than those who didn't. In another study of more than 800 people who said they vaped to help them quit traditional cigarette smoking, only nine percent reported having quit when asked a year later. However, more research is still needed to understand if experimenting with e-cigarettes leads to regular use of smokable tobacco.

Under U.S. Food and Drug Administration (FDA) regulations designed to protect the health of young Americans, minors can no longer buy e-cigarettes in stores or online (see "Government Regulation of E-cigarettes"). The FDA now regulates the manufacture, import, packaging, labeling, advertising, promotion, sale, and distribution of e-cigarettes. This includes components and parts of e-cigarettes but excludes accessories.

Government Regulation of E-cigarettes

In 2016, the FDA established a rule for e-cigarettes and their liquid solutions. Because e-cigarettes contain nicotine derived from tobacco, they are now subject to government regulation as tobacco products. In December 2019, the federal government raised the legal minimum age of sale of tobacco products from 18 to 21 years, and in January 2020, the FDA issued a policy on the sale of flavored vaping cartridges.

How does vaping affect the brain?

The nicotine in e-liquids is readily absorbed from the lungs into the bloodstream when a person vapes an e-cigarette. Upon entering the blood, nicotine stimulates the adrenal glands to release the hormone epinephrine (adrenaline). Epinephrine stimulates the central nervous system and increases blood pressure, breathing, and heart rate. As with most addictive substances, nicotine activates the brain's reward circuits and also increases levels of a chemical messenger in the brain called dopamine, which reinforces rewarding behaviors. Pleasure caused by nicotine's interaction with the reward circuit motivates some people to use nicotine again and again, despite risks to their health and well-being.

What are the health effects of vaping? Is it safer than smoking tobacco cigarettes?

Research so far suggests that vaping devices might be less harmful than combustible cigarettes when people who regularly smoke switch to them as a complete replacement. But nicotine in any form is a highly addictive drug. Research suggests it can even prime the brain's reward system, putting vapers at risk for addiction to other drugs.

Also, e-cigarette use exposes the lungs to a variety of chemicals, including those added to e-liquids, and other chemicals produced during the heating/vaporizing process. A study of some e-cigarette products found the vapor contains known carcinogens and toxic chemicals, as well as potentially toxic metal nanoparticles from the device itself. The study showed that the e-liquids of certain cig-a-like brands contain high levels of nickel and chromium, which may come from the nichrome heating coils of the vaporizing device. Cig-a-likes may also contain low levels of cadmium, a toxic metal also found in cigarette smoke that can cause breathing problems and disease. More research is needed on the health consequences of repeated exposure to these chemicals. There are also reports of lung illnesses and deaths related to inhalation of certain vaping oils into the lungs, which have no way to filter out toxic ingredients.

Reports of Deaths Related to Vaping

The Food and Drug Administration has alerted the public to thousands of reports of serious lung illnesses associated with vaping, including dozens of deaths. They are working with the Centers for Disease Control and Prevention (CDC) to investigate the cause of these illnesses. Many of the suspect products tested by the states or federal health officials have been identified as vaping products containing THC, the main psychotropic ingredient in marijuana. Some of the patients reported a mixture of THC and nicotine; and some reported vaping nicotine alone. While the CDC and FDA continue to investigate possible other contributing substances, CDC has identified a thickening agent-Vitamin E acetate-as a chemical of concern among people with e-cigarette or vaping associated lung injuries. They recommend that people should not use any product containing Vitamin E acetate, or any vaping products containing THC; particularly from informal sources like friends, family, or in-person and online dealers. They also warn against modifying any products purchased in stores, or using any vaping products bought on the street. People, including health professionals, should r eport any adverse effects of vaping products. The CDC has posted an information page for consumers.

Health Effects for Teens

The teen years are critical for brain development, which continues into young adulthood. Young people who use nicotine products in any form, including e-cigarettes, are uniquely at risk for long-lasting effects. Because nicotine affects the development of the brain's reward system, continued nicotine vaping can not only lead to nicotine addiction, but it also can make other drugs such as cocaine and methamphetamine more pleasurable to a teen's developing brain.

Nicotine also affects the development of brain circuits that control attention and learning. Other risks include mood disorders and permanent problems with impulse control-failure to fight an urge or impulse that may harm oneself or others.

Can vaping help a person quit smoking?

Some people believe e-cigarettes may help lower nicotine cravings in those who are trying to quit smoking. However, e-cigarettes are not an FDA-approved quit aid, and there is no conclusive scientific evidence on the effectiveness of vaping for long-term smoking cessation. It should be noted that there are seven FDA-approved quit aids that are proven safe and can be effective when used as directed.

Vaping nicotine has not been thoroughly evaluated in scientific studies. For now, not enough data exists on the safety of e-cigarettes, how the health effects compare to traditional cigarettes, and if they are helpful for people trying to quit smoking.

Points to Remember

People vape with battery-operated devices used to inhale an aerosol, which can contain nicotine, marijuana, flavorings, and other chemicals. In many e-cigarettes, puffing activates the battery-powered heating device, which vaporizes the liquid in the cartridge or reservoir. The person then inhales the resulting aerosol or vapor (called vaping).

Vaping is popular among teens. Under U.S. Food and Drug Administration (FDA) regulations designed to protect the health of young Americans, minors can no longer buy e-cigarettes in stores or online.

Nicotine stimulates the adrenal glands to release the hormone epinephrine (adrenaline) and increases the levels of a chemical messenger in the brain called dopamine. Pleasure caused by nicotine's interaction with the brain's reward system motivates some people to use nicotine again and again, despite possible risks to their health and well-being.

Research so far suggests that vaping is less harmful than combustible cigarettes when people who regularly smoke switch to them as a complete replacement. But e-cigarettes can still damage a person's health.

Vaping can lead to nicotine addiction and increased risk for addiction to other drugs.

Vaping also exposes the lungs to a variety of chemicals, including those added to e-liquids, and other chemicals produced during the heating/vaporizing process.

More research is needed to determine if vaping nicotine can be as effective as smoking cessation aids already approved by the FDA.

Learn More

For more information about e-cigarettes, visit:

NIH-funded study finds teens prefer mint and mango vaping flavors (Science Spotlight, November 2019)

NIDA Live: The Science of Vaping (30:19) (September 2019)

NIDA TV Spotlight on Electronic Cigarettes

A NIDA Science Spotlight on the association between e-cigarette use and future tobacco cigarette use

the FDA's webpage, Vaporizers, E-Cigarettes, and other Electronic Nicotine Delivery Systems (ENDS)

the website, Know the Risks: E-cigarettes & Young People, based on the U.S. Surgeon General's Report on e-cigarette use among youth and young adults; includes various resources such as a parent tip sheet, healthcare provider conversation card, and FAQs

Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students - United States, 2011-2018 (MMRW) (CDC, November 2018)

References

1. Zhu S-H, Sun JY, Bonnevie E, et al. Four hundred and sixty brands of e-cigarettes and counting: Implications for product regulation. Tob Control. 2014;23 Suppl 3:iii3-iii9. doi:10.1136/tobaccocontrol-2014-051670

2. Krishnan-Sarin S, Morean M, Kong G, et al. E-Cigarettes and "dripping" among high-school youth. Pediatrics. 2017; 139(3). doi: https://doi.org/10.1542/peds.2016-3224

3. Leventhal AM, Strong DR, Kirkpatrick MG, et al. Association of electronic cigarette use with initiation of combustible tobacco product smoking in early adolescence. JAMA. 2015;314(7):700-707. doi:10.1001/jama.2015.8950

4. Bold KW, Kong G, Camenga DR, et al. Trajectories of e-cigarette and conventional cigarette use among youth. Pediatrics. December 2017:e20171832. doi:10.1542/peds.2017-1832

5. Chaffee BW, Watkins SL, Glantz SA. Electronic cigarette use and progression from experimentation to established smoking. Pediatrics. March 2018:e20173594. doi:10.1542/peds.2017-3594

6. Kulik MC, Lisha NE, Glantz SA. E-cigarettes associated with depressed smoking cessation: A cross-sectional study of 28 European Union countries. Am J Prev Med. 2018;54(4):603-609. doi:10.1016/j.amepre.2017.12.017

7. Weaver SR, Huang J, Pechacek TF, Heath JW, Ashley DL, Eriksen MP. Are electronic nicotine delivery systems helping cigarette smokers quit? Evidence from a prospective cohort study of U.S. adult smokers, 2015-2016. PLOS ONE. 2018;13(7):e0198047. doi:10.1371/journal.pone.0198047

8. Products C for T. Products, Ingredients & Components - Vaporizers, E-Cigarettes, and other Electronic Nicotine Delivery Systems (ENDS). https://www.fda.gov/TobaccoProducts/Labeling/ProductsIngredientsComponents/ucm456610.htm. Accessed April 17, 2017.

9. Levine A, Huang Y, Drisaldi B, et al. Molecular mechanism for a gateway drug: Epigenetic changes initiated by nicotine prime gene expression by cocaine. Sci Transl Med. 2011;3(107):107ra109. doi:10.1126/scitranslmed.3003062

10. Sleiman M, Logue JM, Montesinos VN, et al. Emissions from electronic cigarettes: Key parameters affecting the release of harmful chemicals. Environ Sci Technol. 2016;50(17):9644-9651. doi:10.1021/acs.est.6b01741

11. Hess CA, Olmedo P, Navas-Acien A, Goessler W, Cohen JE, Rule AM. E-cigarettes as a source of toxic and potentially carcinogenic metals. Environ Res. 2017;152:221-225. doi:10.1016/j.envres.2016.09.026

12. U.S. Department of Health, and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease, Prevention and Health Promotion, Office on Smoking and Health. E-Cigarette Use Among Youth And Young Adults: A Report of the Surgeon General - Executive Summary.; 2016. https://e-cigarettes.surgeongeneral.gov/documents/2016_SGR_Exec_Summ_508.pdf. Accessed February 21, 2017.

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Vaping Devices (Electronic Cigarettes) DrugFacts | National Institute on Drug Abuse

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Vaping devices, also known as e-cigarettes, e-vaporizers, or electronic nicotine delivery systems, are battery-operated devices that people use to inhale an aerosol, which typically contains nicotine (though not always), flavorings, and other chemicals. They can resemble traditional tobacco cigarettes (cig-a-likes), cigars, or pipes, or even everyday items like pens or USB memory sticks.

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3 Things You Learned:

1. Vaping can still have the same health effects in regard to tobacco products.

2. Vaping is commonly mistaken as a healthier alternative to smoking even though they are some chemicals that could harm our bodies.

3. The FDA has concluded that minorities are not allowed to purchase any vaping pens from stores around the country.

2 Questions You Have:

1. Based on the harmful chemicals listed out, does the FDA concluded in any further research regarding vaping pens and e-cigarettes?

2. What are the long effects of vaping?

1 Thing You Want to Know More About:

One thing I would like to learn more about is the long term effects of vaping in the human body and how it can have the same effects to smoking.

Low Tech Twitter Post: Please write a two sentence summary of what you learned today.

Vaping is be harmful to the human body even though many misconept the idea that it is a healthier alternative to smoking. Nobody seems to understand what chemicals are contained in the vaping items and how they could harmfully affect the internal organs.

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1) What are some different types of e-cigarettes and how do they work?

The different types of e-cigarettes are vape pens. They contain a battery and a heating element.

2) What kind of chemicals do e-cigarettes expose the lungs to?

Nicotine, carcinogens, toxic chemicals.

3) Do you think the smoking age should be extended to 21 years of age? Why or why not?

No, because the law will not be considered affected and everyone is still going to consider smoking no matter how old they are.

4) Celebrities such as Katy Perry have been seen vaping. Write a letter to Katy Perry informing her about the harmful effects of vaping that she may not be aware of.

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1) Thin Question: How many deaths does smoking cause each year?

2) Thick Question: Why do people smoke if their are so many deaths per year from smoking?

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Centers for Disease Control and Prevention

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Cigarette smoking harms nearly every organ of the body, causes many diseases, and reduces the health of smokers in general. 1,2

Quitting smoking lowers your risk for smoking-related diseases and can add years to your life. 1,2

Cigarette smoking is the leading cause of preventable death in the United States. ¹

Cigarette smoking causes more than 480,000 deaths each year in the United States. This is nearly one in five deaths.1,2,3

Smoking causes more deaths each year than the following causes combined:⁴

Human immunodeficiency virus (HIV)

Illegal drug use

Alcohol use

Motor vehicle injuries

Firearm-related incidents

More than 10 times as many U.S. citizens have died prematurely from cigarette smoking than have died in all the wars fought by the United States.¹

Smoking causes about 90% (or 9 out of 10) of all lung cancer deaths.1,2 More women die from lung cancer each year than from breast cancer.⁵

Smoking causes about 80% (or 8 out of 10) of all deaths from chronic obstructive pulmonary disease (COPD).¹

Cigarette smoking increases risk for death from all causes in men and women.¹

The risk of dying from cigarette smoking has increased over the last 50 years in the U.S.¹

Smokers are more likely than nonsmokers to develop heart disease, stroke, and lung cancer. ¹

Estimates show smoking increases the risk:

For coronary heart disease by 2 to 4 times1,6

For stroke by 2 to 4 times¹

Of men developing lung cancer by 25 times¹

Of women developing lung cancer by 25.7 times¹

Smoking causes diminished overall health, increased absenteeism from work, and increased health care utilization and cost.¹

Smokers are at greater risk for diseases that affect the heart and blood vessels (cardiovascular disease). 1,2

Smoking causes stroke and coronary heart disease, which are among the leading causes of death in the United States.1,3

Even people who smoke fewer than five cigarettes a day can have early signs of cardiovascular disease.¹

Smoking damages blood vessels and can make them thicken and grow narrower. This makes your heart beat faster and your blood pressure go up. Clots can also form.1,2

A stroke occurs when:

A clot blocks the blood flow to part of your brain;

A blood vessel in or around your brain bursts.1,2

Blockages caused by smoking can also reduce blood flow to your legs and skin.1,2

Smoking can cause lung disease by damaging your airways and the small air sacs (alveoli) found in your lungs. 1,2

Lung diseases caused by smoking include COPD, which includes emphysema and chronic bronchitis.1,2

Cigarette smoking causes most cases of lung cancer.1,2

If you have asthma, tobacco smoke can trigger an attack or make an attack worse.1,2

Smokers are 12 to 13 times more likely to die from COPD than nonsmokers.¹

Smoking can cause cancer almost anywhere in your body: 1,2

Bladder

Blood (acute myeloid leukemia)

Cervix

Colon and rectum (colorectal)

Esophagus

Kidney and ureter

Larynx

Liver

Oropharynx (includes parts of the throat, tongue, soft palate, and the tonsils)

Pancreas

Stomach

Trachea, bronchus, and lung

Smoking also increases the risk of dying from cancer and other diseases in cancer patients and survivors. ¹

If nobody smoked, one of every three cancer deaths in the United States would not happen. 1,2

Smoking harms nearly every organ of the body and affects a person's overall health. 1,2

Smoking can make it harder for a woman to become pregnant. It can also affect her baby's health before and after birth. Smoking increases risks for:1,2,5

Preterm (early) delivery

Stillbirth (death of the baby before birth)

Low birth weight

Sudden infant death syndrome (known as SIDS or crib death)

Ectopic pregnancy

Orofacial clefts in infants

Smoking can also affect men's sperm, which can reduce fertility and also increase risks for birth defects and miscarriage.²

Smoking can affect bone health.1,5
Women past childbearing years who smoke have weaker bones than women who never smoked. They are also at greater risk for broken bones.

Smoking affects the health of your teeth and gums and can cause tooth loss.¹

Smoking can increase your risk for cataracts (clouding of the eye's lens that makes it hard for you to see). It can also cause age-related macular degeneration (AMD). AMD is damage to a small spot near the center of the retina, the part of the eye needed for central vision.¹

Smoking is a cause of type 2 diabetes mellitus and can make it harder to control. The risk of developing diabetes is 30-40% higher for active smokers than nonsmokers.1,2

Smoking causes general adverse effects on the body, including inflammation and decreased immune function.¹

Smoking is a cause of rheumatoid arthritis.¹

Quitting smoking is one of the most important actions people can take to improve their health. This is true regardless of their age or how long they have been smoking. Visit the Benefits of Quitting page for more information about how quitting smoking can improve your health.

1. U.S. Department of Health and Human Services.The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014 [accessed 2017 Apr 20].

2. U.S. Department of Health and Human Services. How Tobacco Smoke Causes Disease: What It Means to You. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2010 [accessed 2017 Apr 20].

3. Centers for Disease Control and Prevention. QuickStats: Number of Deaths from 10 Leading Causes-National Vital Statistics System, United States, 2010. Morbidity and Mortality Weekly Report 2013:62(08);155. [accessed 2017 Apr 20].

4. Mokdad AH, Marks JS, Stroup DF, Gerberding JL. Actual Causes of Death in the United States. JAMA: Journal of the American Medical Association 2004;291(10):1238-45 [cited 2017 Apr 20].

5. U.S. Department of Health and Human Services. Women and Smoking: A Report of the Surgeon General. Rockville (MD): U.S. Department of Health and Human Services, Public Health Service, Office of the Surgeon General, 2001 [accessed 2017 Apr 20].

6. U.S. Department of Health and Human Services. Reducing the Health Consequences of Smoking: 25 Years of Progress. A Report of the Surgeon General. Rockville (MD): U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1989 [accessed 2017 Apr 20].

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See the data and statistical information on health effects of cigarette smoking.