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Red blood cell-derived extracellular vesicles (RBC EVs) are derived from red blood cells. These small fragments are spherical and have been identified as playing a significant role in the cause of sickle cell disease, cardiovascular disease, and thrombosis (Ma et al., 2023). These RBC EVs are so predominant in these illnesses that they are now considered biomarkers for diagnosing said diseases (Ma et al., 2023). Despite the negative correlations with several illnesses, researchers have found that these vesicles are highly stable and can permeate biological barriers, which allows them to transfer their content between cells without much resistance (Ma et al., 2023). RBC EVs are also biocompatible and have low immunogenicity (Ma et al., 2023).   Researchers are currently looking into using RBC EVs as vesicles that can carry specific drugs directly into the cells of the immunocompromised/ill patient. The challenge will be to isolate the RBC EVs from other EVs, as this requires high-speed differential centrifugation and magnetic nanoparticles, which must then be removed from the purified RBC EVs (Ma et al., 2023).

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When used in spontaneous intracerebral hemorrhage, it has been found to decrease hematoma volume by up to 24% (Ma et al., 2023). In cardiac infarct patients, the administration of RBC RVs has been shown to improve DNA synthesis and post-infarct cardiac remodeling (Ma et al, 2023). When derived from EVs, the RBCs will not have a nucleus or DNA, making them homogenous (Ma et al., 2023). The lack of a nucleus will allow for the risk of unpredictable effects of introducing unknown foreign bodies to be removed from the entire process (Ma et al, 2023).

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RBC EVs have been known to cause hypercoagulation when involved in transfusions (Ma et al., 2023). It is thought that the longer the RBC EVs are stored, the more they are prone to causing hypercoagulation (Ma et al., 2023). They have also been found to contribute to Parkinson's Disease by transporting toxins from one part of the brain to another (Ma et al., 2023). RBC EVs have been found to cause Sickle Cell Disease as they contribute to a hypercoagulable state (Ma et al., 2023).

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The use of Red Blood Cell-Derived Extracellular Vesicles (RBC EVs) as biomarkers for diagnosing Cardiovascular disease, Parkinson's, and malaria, among other diseases, is an excellent innovation (Ma et al., 2023). An even bigger innovation is the use of the RBC EVs as vesicles to carry medication and treatments into the affected person’s body as a treatment for various cancers and other illnesses (Ma et al., 2023). Illnesses such as malaria, sickle cell disease, Parkinson’s, coronary vascular disease, and sudden ischemia affect a very large percentage of our population, and many at a very young age. As you can see from the pros and cons of using the RBC EVs,  the benefits outweigh the risks.

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My strengths are empathy, achiever, relator, connectedness, and arranging.

Achiever (executing) works hard.

Arranger (executing), organized but flexible.

Connectedness (relationship builder) Have faith in the team, look at the big picture, and help others see purpose.

Empathy (relationship builder) customizes approach to people and knows what to say and do.

Relator (relationship builder) builds close relationships, allowing for job satisfaction by working hard alongside friends to achieve a goal.

*** My five strengths will allow me to create a close-knit team that is heard and respected, creating a positive environment in which team members feel valued. This type of positive environment increases job productivity and teamwork toward a common goal. I would work hard alongside the rest of the team, helping give each one a sense of purpose while keeping the entire team united and on track.

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Angelica—Analytical (strategic thinking): Consider all factors that may affect a situation and search for reasons and causes.

Faith-futuristic (strategic thinking) people are inspired by their vision of the future and what could be. They are imaginative and creative.

Daisy-Developer (relationship building) recognizes and cultivates people's potential. A coach or mentor helps others grow.

Fernando-Focus (executing) stays on track, prioritizes, and follows through with tasks. They set and attain goals.

Daniel-Discipline ( executing) creates structure. Great planner, breaks down complex ideas into smaller steps that are easier to comprehend.

***My team has strengths that balance and complement mine. My strengths are in executing and relationship building, but I lack strategic thinking. Our cumulative strengths will allow us to create structure and stay on track while seeing what the possibilities are and what the future can hold if we remain on task and work through challenges and obstacles.

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https://urldefense.com/v3/__https://pmc.ncbi.nlm.nih.gov/articles/PMC10604118/__;!!CNnezw0!5e9Qr3wtCrgVaacZaRM72Z0JQhgJIHeZFSUUqq048ZAOOSDpdJCox50udVdsbQ9Y2bvrU7xxB9Yr8lJ8LplcPEg_85sc4AS7DB1bbTMCVQ$