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"Conceal me what I am, and be my aid
For such disguise as haply shall become
The form of my intent." (1.2.53-55)
This quote can now be seen as things are not what they necessarily seem to be, they can be much different. One example could be Lance Armstrong. He was seen as a champion, a true hero for many years. Once he was caught for doping, everything changed and reality set face.

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"Go, Sir Andrew. Scout me for him at the corner
the orchard like a bum-baily. So soon as ever
thou seest him, draw, and as thou draw'st, swear
horrible; for it comes to pass oft that a terrible oath,
with a swaggering accent sharply twanged off, gives
manhood more approbation than ever proof itself
would have earned him. Away!" (3.4.184-190)

The way manhood is discussed these days is different than it was in Elizabethan England.  Now manhood is not necessarily measured by fighting. Manhood can be measured by things like responsibility, actions and words.

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"Alas, our frailty is the cause, not we,
For such as we are made of, such we be." (2.2.31-32)
Back in the day women were considered weak and frail. Today in most places it is the complete opposite. There are many strong women doing things that back in the day, seemed impossible. One example would be Hillary Clinton who became the first female presidential candidate.

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"I am not what I am." (3.1.148)
Cesario says that to Olivia suggesting that she isn't who she says she is. This reminds me of Caitlyn Jenner and all those who are lost within themselves. Some/Most then come out and embrace their identity.