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Lugoff-Elgin High School is located in the Lugoff area and serves students in grades 9-12. Lugoff-Elgin High is part of the Kershaw County School District.

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Genes and Mutations - Germinal and Somatic Mutations

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Most tissues are derived from a cell or a few progenitor cells. If a mutation occurs in one of the progenitor cells, all of its daughter cells will also express the mutation. For this reason, somatic mutations generally appear as a sector on the mutated individual.

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Genetic Mutation | Learn Science at Scitable

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A mutation is a heritable change in the nucleotide sequence of an organism's DNA that ultimately serves as a source of genetic diversity. A single base change can create a devastating genetic disorder or a beneficial adaptation, or it might have no effect on the phenotype of an organism whatsoever.

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Albino Doberman pinschers share a similar gene with humans who also have the condition, scientists say.

Credit: Michigan State University

Dogs and people have more in common than a love of Frisbees and long walks on the beach. A new study finds that certain dogs, just like certain humans, carry a gene mutation that causes albinism - a condition that results in little or no pigment in the eyes, skin and hair.

The study by researchers at Michigan State University identifies the exact genetic mutation that leads to albinism in Doberman pinschers, a discovery that has eluded veterinarians and dog breeders until now. Interestingly, the same mutated gene that causes albinism in this dog breed is also associated with a form of albinism in humans.

"What we found was a gene mutation that results in a missing protein necessary for cells to be pigmented," study co-author Paige Winkler, a doctoral student in the College of Veterinary Medicine at Michigan State University in East Lansing, Michigan, said in a statement. [ The Pink and White Album: Amazing Albino Animals]

Winkler said the gene mutation found in Doberman pinschers is responsible for a condition known as oculocutaneous albinism, which also affects humans. The condition expresses certain characteristics in both humans and dogs.

"With an albino Doberman, you see a white or lighter-colored coat, pink noses and lips, along with pale irises in the eyes," Winkler said. "These traits are very similar to the characteristics humans display with this particular condition, causing light-pigmented skin and hair, along with eye discoloration and vision disturbances."

Just as people with this type of albinism experience skin sensitivity to sunlight, which can result in an increased vulnerability to skin tumors, canines with the mutated gene were also found to be at higher risk for developing skin tumors, the researchers said.

"We knew that albino Dobermans typically developed these types of tumors, much like [albino] humans, but we wondered what the actual increase in prevalence was between a 'white' dog and a regular-colored Doberman," said Joshua Bartoe, an assistant professor in the Department of Small Animal Clinical Sciences at Michigan State University, who co-led the study. "What we found was a significant increase in risk for development of melanoma-like tumors in the albino dogs."

These findings were based on a study of 40 Dobermans pinschers - 20 albino dogs and 20 "regular-colored" dogs. The researchers found that more than half of the albino dogs had at least one tumor, while only one of the regular-colored dogs had a tumor.

Bartoe and Winkler said their study could serve as a valuable resource for Doberman breeders around the world, particularly because the American Kennel Club, a registry of purebred dog pedigrees in the United States, doesn't allow the registration of albino dogs.

"Because Dobermans can carry the defective gene, but show no signs of the [condition], this has posed serious problems among breeders," Bartoe said. "But now that we've identified the mutation, we can look at the genetic makeup of these dogs and determine if they might be carriers."

The results of the new study were published March 19 in the journal PLOS ONE.

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Dogs and people have more in common than a love of Frisbees and long walks on the beach. A new study finds that certain dogs, just like certain humans, carry a gene mutation that causes albinism - a condition that results in little or no pigment in the eyes, skin and hair.

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A summary of Mutations in 's Genetic Code. Learn exactly what happened in this chapter, scene, or section of Genetic Code and what it means. Perfect for acing essays, tests, and quizzes, as well as for writing lesson plans.

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What is a gene mutation and how do mutations occur?

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Most disease-causing gene mutations are uncommon in the general population. However, other genetic changes occur more frequently. Genetic alterations that occur in more than 1 percent of the population are called polymorphisms. They are common enough to be considered a normal variation in the DNA.

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To purchase this program please visit http://www.greatpacificmedia.com/ Segment from the program DNA, RNA, and Protein Synthesis: Information to Structure. DVD Description Our DNA DVD looks first at the structure of DNA before going on to describe how DNA carries out its four major functions: the storage of information; the replication of information; creating slight changes in the information through mutations that forces of natural selection act upon; and the translating of information into the proteins that define an individual.

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Population Genetics: When Darwin Met Mendel - Crash Course Biology #18

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Hank talks about population genetics, which helps to explain the evolution of populations over time by combing the principles of Mendel and Darwin, and by means of the Hardy-Weinberg equation. Crash Course Biology is now available on DVD!

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Hannah Lombardi