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March 14, 1958
Cuba formed a regime and acted independently against the US.
The total estimated cost to Cuba from this embargo is $144b.

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1950
A sanction against North Korea began in 1950 under the Trading with the Enemy Act of 1917, and in 2017, after a tourist death, the US allowed itself to cut from its financial system and freeze any business involving North Korea.
It has so far impeded or reduced the nuclear arsenal development of North Korea.

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March-August 2004
The US issued these sanctions as a follow up on their policy of combating the Axis of evil.
The sanctions have significantly impacted humanitarian efforts in Syria significantly.

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1995
The US imposed sanctions and almost an entire embargo against Iran in response to their nuclear arms development.
The harsh sanctions have had a significant impact on the Iranian economy, affecting all branches.

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February 2014
These sanctions were made in response to the illegal annexation of Crimea as a Russian state.
The sanctions on Crimea against the US had a significant impact on the Russian Ruble, increasing capital flight as well.