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Onset of action: Heart rate control: Oral: 1 to 2 hours; IV: 5 to 60 minutes
Peak effect: Heart rate control: Oral: 2 to 8 hours; IV: 1 to 6 hours
Metabolism: liver 16%; CYP450: unknown

Excretion: urine (50-70% unchanged); Half-life: 1.5-2 days, 3.5-5 days (anuria)

NJ

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Brand: Lanoxin, Digitek
Generic: digoxin
Class: Anti-arrhythmic Agent
Image from https://en.wikipedia.org/wiki/Digitoxin

BY

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Monitor laboratory tests when beginning or changing dosage, especially with IV administration.
IV: Monitor ECG continuously.
Oral: Monitor apical pulse before administering any dose. Decreased heart rate is an expected response.
Teach patient to report non-cardiac signs of toxicity (eg; anorexia, blurred vision, "yellow" vision, and confusion).

NJ

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Which client should NOT take digoxin?
A. A 38 year old female with renal impairments
B. A 75 year old male who has ventricular arrhythmias
C. A 52 year old male with hypothyroidism
D. A 44 year old female who has heart failure with a reduced ejection fraction

BY

# data[].attributes.body
Burchum, J.R.& Rosenthal, L.D. (2019). Pharmacology for Nursing Care (10th ed.). Elsevier.

Digoxin. (2022). Lexicomp. https://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/6745?cesid=6FTkhY8Ebxy&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Ddigoxin%26t%3Dname%26acs%3Dfalse%26acq%3Ddigoxin#phk

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- Accelerated atrioventricular junctional rhythm
- Asystole
- Atrial tachycardia
- Skin rash
- Abdominal pain
- Thrombocytopenia
- Blurred vision

BY

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Used for atrial fibrillation and for heart failure patients with a reduced ejection fraction.

NJ

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Digoxin stops the sodium-potassium pump, which increases the amount of sodium in the cells, which in turn, increases the concentration of calcium. In severe cases, hypercalcemia can cause arrhythmias.

Image from https://www.medicinehow.com/how-does-
digoxin-work/

NJ