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1_ NUCLEOPHILIC ADDITION REACTION
2_ NUCLEOPHILIC ADDITION REACTION FOLLOWED BY ELIMINATION OF H₂O
3_ REDUCTION REACTIONS
4_ OXIDATION REACTIONS

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THE REMAINING TWO BONDS ARE TO THE OTHER CARBON ATOMS OR HYDROCARBON RADICALS (R)

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CHEMICAL COMPOUND

ORGANIC COMPOUND CHARACTERIZED BY THE PRESENCE OF A CARBONYL GROUP IN WHICH THE CARBON ATOM IS COVALENTLY BONDED TO AN OXYGEN ATOM.

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MOST WIDELY USED AS:
1_ SOLVENTS (especially in manufacturing explosives)
2_ LACQUERS
3_ PAINTS
4_TEXTILES
5_ TANNING
6_ PRESERVATIVES
7_ HYDRAULIC FLUIDS

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1_ HIGHLY REACTIVE COMPOUNDS.
2_ GENERALLY HAVE A PLEASANT SMELL. THE ODOR BECOMES MORE FRAGANT.
3_ MISCIBLES WITH WATER
4_ POLAR MOLECULES

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1_ KETONES UPSET THE CHEMICAL BALANCE OF THE BLOOD AND, IF LEFT UNTREATED, CAN POISON THE BODY.
2_ KETONES BODIES ARE PRODUCED BY THE LIVER AND USED PERIPHERALLY AS AN ENERGY SOURCE WHEN GLUCOSE IS NOT READILY AVAILABLE.
3_ KETOSIS IS A METABOLIC STATE IN WHICH KETONES BECOME AN IMPORTANT SOURCE OF ENERGY FOR THE BODY AND BRAIN, IT OCCURS WHEN CARB INTAKE AND INSULIN LEVELS ARE LOW.
4_ KETONES CAN CROSS THE BLOOD-BRAIN BARRIER AND PROVIDE ENERGY FOR YOUR BRAIN IN THE ABSENCE OF GLUCOSE.

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https://www.britannica.com/science/ketone

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Ketone, any of a class of organic compounds characterized by the presence of a carbonyl group in which the carbon atom is covalently bonded to an oxygen atom. The remaining two bonds are to other carbon atoms or hydrocarbon radicals (R):

Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.

Only a small number of ketones are manufactured on a large scale in industry. They can be synthesized by a wide variety of methods, and because of their ease of preparation, relative stability, and high reactivity, they are nearly ideal chemical intermediates. Many complex organic compounds are synthesized using ketones as building blocks. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.

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The most important ketone is acetone (CH ₃COCH ₃), a liquid with a sweetish odour. Acetone is one of the few organic compounds that is infinitely soluble in water (i.e., soluble in all proportions); it also dissolves many organic compounds. For this reason-and because of its low boiling point (56 °C [132.8 °F]), which makes it easy to remove by evaporation when no longer wanted-it is one of the most important industrial solvents, being used in such products as paints, varnishes, resins, coatings, and nail-polish removers.

The International Union of Pure and Applied Chemistry (IUPAC) name of a ketone is derived by selecting as the parent the longest chain of carbon atoms that contains the carbonyl group. The parent chain is numbered from the end that gives the carbonyl carbon the smaller number. The suffix -e of the parent alkane is changed to -one to show that the compound is a ketone. For example, CH ₃CH ₂COCH ₂CH(CH ₃) ₂ is named 5-methyl-3-hexanone. The longest chain contains six carbon atoms and numbering of the carbon must begin at the end that gives the smaller number to the carbonyl carbon. The carbonyl group is on carbon 3, and the methyl group is on carbon 5. In cyclic ketones, numbering of the atoms of the ring begins with the carbonyl carbon as number 1. Common names for ketones are derived by naming each carbon group bonded to carbon as a separate word followed by the word "ketone."

The simplest ketone, CH ₃COCH ₃, whose IUPAC name is 2-propanone, is almost always called by its common name, acetone, which is derived from the fact that it was first prepared by heating the calcium salt of acetic acid.

Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions. A major reason is that the carbonyl group is highly polar; i.e., it has an uneven distribution of electrons. This gives the carbon atom a partial positive charge, making it susceptible to attack by nucleophiles, which are species attracted to positively charged centres. Typical reactions include oxidation-reduction and nucleophilic addition. The polarity of the carbonyl group affects the physical properties of ketones as well.

Secondary alcohols are easily oxidized to ketones (R ₂CHOH → R ₂CO). The reaction can be halted at the ketone stage because ketones are generally resistant to further oxidation. Oxidation of a secondary alcohol to a ketone can be accomplished by many oxidizing agents, most often chromic acid (H ₂CrO ₄), pyridinium chlorochromate (PCC), potassium permanganate (KMnO ₄), or manganese dioxide (MnO ₂). With a few exceptions (such as oxidative cleavage of cyclohexanone, C ₆ H ₁₀O, to adipic acid, HO ₂C[CH ₂] ₄CO ₂H, a compound used to make nylon-6,6), the oxidation of ketones is not synthetically useful.

The treatment of an aromatic hydrocarbon with an acyl halide or anhydride in the presence of a catalyst composed of a Lewis acid (i.e., a compound capable of accepting an electron pair), most often aluminum chloride (AlCl ₃), gives an aryl alkyl or diaryl ketone (ArH → ArCOR or ArCOAr′), where Ar represents an aromatic ring. This reaction is known as Friedel-Crafts acylation.

Nitriles (RCN) react with Grignard reagents to produce ketones, following hydrolysis (RCN + R′MgX → RCOR′).

Ketones possessing α-hydrogens can often be made to undergo aldol reactions (also called aldol condensation) by the use of certain techniques. The reaction is often used to close rings, in which case one carbon provides the carbonyl group and another provides the carbon with an α-hydrogen. An example is the synthesis of 2-cyclohexenone. In this example, the aldol product undergoes loss of H ₂O to give an α, β-unsaturated ketone.
William H. Brown

Learn More in these related Britannica articles:

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ketone | Definition, Properties, & Facts

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Ketone, any of a class of organic compounds characterized by the presence of a carbonyl group in which the carbon atom is covalently bonded to an oxygen atom. The remaining two bonds are to other carbon atoms or hydrocarbon radicals. The most important ketone is acetone, a liquid with a sweetish odor.