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noun

the habitual misuse of alcohol.
"Stephanie's father was put into rehab for alcohol abuse"

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noun

An addiction to the consumption of alcoholic liquor or the mental illness and compulsive behavior resulting from alcohol dependency.
"he had a long history of depression, drug abuse and alcoholism"

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Alcohol abuse means having an unhealthy relationship with alcohol or dangerous drinking habits.

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Queensland University of Technology (QUT) researchers have identified a drug that could potentially help our brains reboot and reverse the damaging impacts of heavy alcohol consumption on regeneration of brain cells.

Their studies in adult mice show that two weeks of daily treatment with the drug tandospirone reversed the effects of 15 weeks of binge-like alcohol consumption on neurogenesis -- the ability of the brain to grow and replace neurons (brain cells). The findings have been published in Scientific Reports.

This is the first time tandospirone has be shown to reverse the deficit in brain neurogenesis induced by heavy alcohol consumption

Tandospirone acts selectively on a serotonin receptor (5-HT1A)

The researchers also showed in mice that the drug was effective in stopping anxiety-like behaviours associated with alcohol withdrawal, and this was accompanied by a significant decrease in binge-like alcohol intake

"This is a novel discovery that tandospirone can reverse the deficit in neurogenesis caused by alcohol," said study leader neuroscientist Professor Selena Bartlett from QUT's Institute of Health and Biomedical Innovation.

"We know that with heavy drinking you are inhibiting your ability to grow new neurons, brain cells. Alcohol is specifically very damaging for neurons.

"Other studies in mice have shown that tandospirone improves brain neurogenesis, but this is the first time it has been shown that it can totally reverse the neurogenic deficits induced by alcohol.

"This opens the way to look at if neurogenesis is associated with other substance-abuse deficits, such as in memory and learning, and whether this compound can reverse these."

Professor Bartlett, who is based at the Translational Research Institute, said the discovery by study co-authors QUT postdoctoral research fellows Dr Arnauld Belmer and Dr Omkar Patkar came about serendipitously after research started in a different direction.

"It was surprising, and exciting," Dr Belmer said.

"This drug is relatively new and available only in China and Japan. It is commonly used there and shown to be highly effective in treating general anxiety and well tolerated with limited adverse effects."

Professor Bartlett said researchers are constantly looking at new treatment strategies for alcohol abuse and addiction, which is characterised by extended periods of heavy alcohol use, binges and abstinence, and anxiety and depression which contribute to relapse.

"This is not just another drug that shows promise in helping to reduce binge drinking," she said.

"While it could possibly have that effect, it might be able to help reboot the brain and reverse the deficits the alcohol abuse causes -- both the inhibition to the brain's ability to regenerate, and the behavioural consequences that come from what alcohol is doing to the brain, like increases in anxiety and depression."

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birth defects; brain tumor; psychology research; infant's health; alcoholism; addiction; brain injury; disorders and syndromes

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Drug shown to reverse brain deficits caused by alcohol

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Researchers have identified a drug that could potentially help our brains reboot and reverse the damaging impacts of heavy alcohol consumption on regeneration of brain cells. Their studies in adult mice show that two weeks of daily treatment with the drug tandospirone reversed the effects of 15 weeks of binge-like alcohol consumption on neurogenesis - the ability of the brain to grow and replace neurons (brain cells).

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Alcohol Use in the United States:

Prevalence of Drinking: According to the 2015 National Survey on Drug Use and Health (NSDUH), 86.4 percent of people ages 18 or older reported that they drank alcohol at some point in their lifetime; 70.1 percent reported that they drank in the past year; 56.0 percent reported that they drank in the past month.¹

Prevalence of Binge Drinking and Heavy Alcohol Use: In 2015, 26.9 percent of people ages 18 or older reported that they engaged in binge drinking in the past month; 7.0 percent reported that they engaged in heavy alcohol use in the past month.² (See "Definitions" box for definitions of binge drinking and heavy alcohol use.)

Alcohol Use Disorder (AUD) in the United States:

Adults (ages 18+): According to the 2015 NSDUH, 15.1 million adults ages 18 and older³ (6.2 percent of this age group⁴) had AUD. This includes 9.8 million men³ (8.4 percent of men in this age group⁴) and 5.3 million women³ (4.2 percent of women in this age group⁴).
About 6.7 percent of adults who had AUD in the past year received treatment. This includes 7.4 percent of males and 5.4 percent of females with AUD in this age group.⁵

Youth (ages 12-17): According to the 2015 NSDUH, an estimated 623,000 adolescents ages 12-17⁶ (2.5 percent of this age group⁷) had AUD. This number includes 298,000 males⁶ (2.3 percent of males in this age group⁷) and 325,000 females⁶ (2.7 percent of females in this age group⁷).

About 5.2 percent of youth who had AUD in the past year received treatment. This includes 5.1 percent of males and 5.3 percent of females with AUD in this age group.⁵

Alcohol-Related Deaths:

An estimated 88,000⁸ people (approximately 62,000 men and 26,000 women⁸) die from alcohol-related causes annually, making alcohol the third leading preventable cause of death in the United States. The first is tobacco, and the second is poor diet and physical inactivity.⁹

In 2014, alcohol-impaired driving fatalities accounted for 9,967 deaths (31 percent of overall driving fatalities).¹⁰

Economic Burden:

In 2010, alcohol misuse cost the United States $249.0 billion.¹¹

Three-quarters of the total cost of alcohol misuse is related to binge drinking.¹¹

Global Burden:

In 2012, 3.3 million deaths, or 5.9 percent of all global deaths (7.6 percent for men and 4.1 percent for women), were attributable to alcohol consumption.¹²

In 2014, the World Health Organization reported that alcohol contributed to more than 200 diseases and injury-related health conditions, most notably DSM-IV alcohol dependence (see sidebar), liver cirrhosis, cancers, and injuries.¹³ In 2012, 5.1 percent of the burden of disease and injury worldwide (139 million disability-adjusted life-years) was attributable to alcohol consumption.¹²

Globally, alcohol misuse was the fifth leading risk factor for premature death and disability in 2010. Among people between the ages of 15 and 49, it is the first.¹⁴ In the age group 20-39 years, approximately 25 percent of the total deaths are alcohol attributable.¹⁵

Family Consequences:

More than 10 percent of U.S. children live with a parent with alcohol problems, according to a 2012 study.¹⁶

Underage Drinking:

Prevalence of Underage Alcohol Use:

Prevalence of Drinking: According to the 2015 NSDUH, 33.1 percent of 15-year-olds report that they have had at least 1 drink in their lives.¹⁷ About 7.7 million people ages 12-20¹⁸ (20.3 percent of this age group¹⁹) reported drinking alcohol in the past month (19.8 percent of males and 20.8 percent of females¹⁹).

Prevalence of Binge Drinking: According to the 2015 NSDUH, approximately 5.1 million people¹⁸ (about 13.4 percent¹⁹) ages 12-20 (13.4 percent of males and 13.3 percent of females¹⁹) reported binge drinking in the past month.

Prevalence of Heavy Alcohol Use: According to the 2015 NSDUH, approximately 1.3 million people¹⁸ (about 3.3 percent¹⁹) ages 12-20 (3.6 percent of males and 3.0 percent of females¹⁹) reported heavy alcohol use in the past month.

Consequences of Underage Alcohol Use:
Research indicates that alcohol use during the teenage years could interfere with normal adolescent brain development and increase the risk of developing AUD. In addition, underage drinking contributes to a range of acute consequences, including injuries, sexual assaults, and even deaths-including those from car crashes.²⁰

Alcohol and College Students:

Prevalence of Alcohol Use:

Prevalence of Drinking: According to the 2015 NSDUH, 58.0 percent of full-time college students ages 18-22 drank alcohol in the past month compared with 48.2 percent of other persons of the same age.²¹

Prevalence of Binge Drinking: According to the 2015 NSDUH, 37.9 percent of college students ages 18-22 reported binge drinking in the past month compared with 32.6 percent of other persons of the same age.²¹

Prevalence of Heavy Alcohol Use: According to the 2015 NSDUH, 12.5 percent of college students ages 18-22 reported heavy alcohol use in the past month compared with 8.5 percent of other persons of the same age.²¹

Consequences-Researchers estimate that each year:

1,825 college students between the ages of 18 and 24 die from alcohol-related unintentional injuries, including motor-vehicle crashes.²²

696,000 students between the ages of 18 and 24 are assaulted by another student who has been drinking.²³

97,000 students between the ages of 18 and 24 report experiencing alcohol-related sexual assault or date rape.²³

Roughly 20 percent of college students meet the criteria for AUD.²⁴

About 1 in 4 college students report academic consequences from drinking, including missing class, falling behind in class, doing poorly on exams or papers, and receiving lower grades overall.²⁵

Alcohol and Pregnancy:

The prevalence of Fetal Alcohol Syndrome (FAS) in the United States was estimated by the Institute of Medicine in 1996 to be between 0.5 and 3.0 cases per 1,000.²⁶

More recent reports from specific U.S. sites report the prevalence of FAS to be 2 to 7 cases per 1,000, and the prevalence of Fetal Alcohol Spectrum Disorders (FASD) to be as high as 20 to 50 cases per 1,000.27,28

Alcohol and the Human Body:

In 2015, of the 78,529 liver disease deaths among individuals ages 12 and older, 47.0 percent involved alcohol. Among males, 49,695 liver disease deaths occurred and 49.5 percent involved alcohol. Among females, 28,834 liver disease deaths occurred and 43.5 percent involved alcohol.²⁹

Among all cirrhosis deaths in 2013, 47.9 percent were alcohol related. The proportion of alcohol-related cirrhosis was highest (76.5 percent) among deaths of persons ages 25-34, followed by deaths of persons ages 35-44, at 70.0 percent.³⁰

In 2009, alcohol-related liver disease was the primary cause of almost 1 in 3 liver transplants in the United States.³¹

Drinking alcohol increases the risk of cancers of the mouth, esophagus, pharynx, larynx, liver, and breast.³²

Definitions

Alcohol Use Disorder (AUD): AUD is a chronic relapsing brain disease characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD can range from mild to severe, and recovery is possible regardless of severity. The fourth edition of the Diagnostic and Statistical Manual (DSM-IV), published by the American Psychiatric Association, described two distinct disorders-alcohol abuse and alcohol dependence-with specific criteria for each. The fifth edition, DSM-5, integrates the two DSM-IV disorders, alcohol abuse and alcohol dependence, into a single disorder called alcohol use disorder, or AUD, with mild, moderate, and severe subclassifications.
Binge Drinking:

NIAAA defines binge drinking as a pattern of drinking that brings blood alcohol concentration (BAC) levels to 0.08 g/dL. This typically occurs after 4 drinks for women and 5 drinks for men-in about 2 hours.³³

The Substance Abuse and Mental Health Services Administration (SAMHSA), which conducts the annual National Survey on Drug Use and Health (NSDUH), defines binge drinking as 5 or more alcoholic drinks for males or 4 or more alcoholic drinks for females on the same occasion (i.e., at the same time or within a couple of hours of each other) on at least 1 day in the past month.³⁴

Heavy Alcohol Use: SAMHSA defines heavy alcohol use as binge drinking on 5 or more days in the past month.

NIAAA's Definition of Drinking at Low Risk for Developing AUD: For women, low-risk drinking is defined as no more than 3 drinks on any single day and no more than 7 drinks per week. For men, it is defined as no more than 4 drinks on any single day and no more than 14 drinks per week. NIAAA research shows that only about 2 in 100 people who drink within these limits have AUD.

Alcohol-Impaired-Driving Fatality: A fatality in a crash involving a driver or motorcycle rider (operator) with a BAC of 0.08 g/dL or greater.

Disability-Adjusted Life-Years (DALYs): A measure of years of life lost or lived in less than full health.

Underage Drinking: Alcohol use by anyone under the age of 21. In the United States, the legal drinking age is 21.

¹ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 2.41B-Alcohol Use in Lifetime, Past Year, and Past Month among Persons Aged 12 or Older, by Demographic Characteristics: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab2-41b. Accessed 1/18/17.

2 Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 2.46B-Alcohol Use, Binge Alcohol Use, and Heavy Alcohol Use in Past Month among Persons Aged 12 or Older, by Demographic Characteristics: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab2-46b. Accessed 1/18/17.

³ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 5.6A-Substance Use Disorder in Past Year among Persons Aged 18 or Older, by Demographic Characteristics: Numbers in Thousands, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab5-6a. Accessed 1/18/17.

⁴ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 5.6B-Substance Use Disorder in Past Year among Persons Aged 18 or Older, by Demographic Characteristics: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab5-6b. Accessed 1/18/17.

⁵ Substance Abuse and Mental Health Services Administration (SAMHSA). National Survey on Drug Use and Health (NSDUH). 2015 (NSDUH-2015-DS0001) Public-Use File Dataset. Available at: https://www.datafiles.samhsa.gov/study-dataset/national-survey-drug-use-and-health-2015-nsduh-2015-ds0001-nid16894. Accessed 6/15/17.

⁶ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 5.5A-Substance Use Disorder in Past Year among Persons Aged 12 to 17, by Demographic Characteristics: Numbers in Thousands, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab5-5a. Accessed 1/18/17.

⁷ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 5.5B-Substance Use Disorder in Past Year among Persons Aged 12 to 17, by Demographic Characteristics: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab5-5b. Accessed 1/18/17.

¹⁷ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 2.19B-Alcohol Use in Lifetime, Past Year, and Past Month, by Detailed Age Category: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab2-19b. Accessed 1/18/17.

¹⁸ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 Key Substance Use and Mental Health Indicators in the United States: Results from the 2015 National Survey on Drug Use and Health. Figure 24. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-FFR1-2015/NSDUH-FFR1-2015/NSDUH-FFR1-2015.htm#fig24. Accessed 1/18/17.

¹⁹ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 2.83B-Alcohol Use, Binge Alcohol Use, and Heavy Alcohol Use in Past Month among Persons Aged 12 to 20, by Demographic Characteristics: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab2-83b. Accessed 1/18/17.

²¹ Substance Abuse and Mental Health Services Administration (SAMHSA). 2015 National Survey on Drug Use and Health (NSDUH). Table 6.84B-Tobacco Product and Alcohol Use in Past Month among Persons Aged 18 to 22, by College Enrollment Status: Percentages, 2014 and 2015. Available at: https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015/NSDUH-DetTabs-2015.htm#tab6-84b. Accessed 1/18/17.

²⁶ Stratton, K.; Howe, C.; Battaglia, F.; Eds. Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment. Washington, DC: Institute of Medicine, National Academy Press, 1996.

²⁹ Estimated liver disease deaths include deaths with the underlying cause of death coded as alcoholic liver disease (K70), liver cirrhosis, unspecified (K74.3-K74.6, K76.0, K76.9), liver cancer (C22), or other liver diseases (K71, K72, K73, K74.0-K74.2, K75, and K76.1-K76.8). Number of deaths from Multiple Cause of Death Public-Use Data File, 2015 ( http://wonder.cdc.gov/mcd.html). Alcohol-attributable fractions (AAFs) from CDC Alcohol-Related Disease Impact ( http://nccd.cdc.gov/DPH_ARDI/Default/Default.aspx, Accessed 5/23/17). Prevalence of alcohol consumption from the National Survey on Drug Use and Health, 2015, for estimating indirect AAFs for liver cancer.

Updated August 2018

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Prevalence of Drinking: According to the 2015 National Survey on Drug Use and Health (NSDUH), 86.4 percent of people ages 18 or older reported that they drank alcohol at some point in their lifetime; 70.1 percent reported that they drank in the past year; 56.0 percent reported that they drank

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0:00 / 0:15•Watch full video

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Beyond Today -- Overcoming Alcohol Abuse

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You and your family need to know that recovery from the bondage of chronic alcohol abuse and alcoholism is possible. ======== Watch this Program, Read the Transcript or Submit a Comment https://www.ucg.org/beyond-today/beyond-today-television-program/overcoming-alcohol-abuse?source=youtube ======== FREE Bible Study Aid Overcoming Alcoholism: There Is Hope!