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The most obvious difference between the book and the movie is their titles. The book title is "Simon vs the Homo Sapiens Agenda," which refers to something Simon mentioned in one of his emails to Blue. "Love, Simon" is used as the movie title which is how Simon signed off his last emails to Blue.

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In SVTHSA, Simon had an older sister named Alice in college and a younger sister named Nora, a freshman at the same high school as Simon.
In "Love, Simon," Simon had one sister and Nora seemed a lot younger.

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In the book, Simon's email was "Hourtohour.notetonote@gmail.com," which is a lyric from an Elliott Smith song. (Blue noticed that on page 102).
In the movie, Simon happened to be listening to a different Elliott Smith song when he created his email, and named it "frommywindow1@gmail.com." In the movie "Hour to hour" was on Simon's chalkboard wall, but not his email.

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So the bullies in SVTHSA targeted Simon with signs in the back of the auditorium during play rehearsal and Abby and Taylor were the first ones to stand up for Simon. In the movie, this scene took place during lunch, and none of Simon's friends stood up for him. Also, the movie involved Ethan, the other out kid at school.

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First of all, the host of the party was different. Garrett hosted in the book, whereas Bram hosted in the movie.
Also, the costumes weren't the same in both. Simon and Leah in the movie were John Lennon and Yoko Ono instead of a dementor and manga character. One more difference was that in the book, the Freudian slip costume was worn by a random girl, not Martin. Abby was still Wonder Woman though.

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In SVTHSA, Abby was a cheerleader, and in the movie, she most definitely was not.

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In the book, Abby rejected Martin privately and Martin's subsequent post on creeksecrets was mostly driven by his internal emotions and embarrassment. In the movie, homecoming was a big deal, and Martin decided to go big when he asked out Abby, and was rejected in front of the whole school. He posted Simon’s emails to change the topic on creeksecrets because he was sick of getting attacked on the tumblr.

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Not significant, but in SVTHSA the play was Oliver, but in the movie, they put on Cabaret.

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Lyle. (And Other Blues) **major spoilers**

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Lyle. (And Other Blues) **major spoilers**

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In the book, Simon only had one guess for basically the whole book, and when it wasn't Cal, he was shocked. In the movie, Simon thought it was Bram, then Lyle, then Cal, and there was a lot going on there.

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"I'm post presidency Barack Obama. Just chillin in Hawaii, drinking mai tais, writing memoirs, and hoping Trump doesn't destroy my legacy."

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In the book, Simon's friends took him into the city to a gay bar where he got drunk and met a very accepting guy who helped him feel more himself. He also got to have supportive friends who took him there and made sure he was safe. In the movie, Simon's friends were so hurt by Simon's actions, that they were unsupportive even around the bullies.

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When Simon first met Blue in SVTHSA, they were on the tilt a whirl, not the ferris wheel.

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In Simon vs, Leah liked Nick, but in the movie, Simon thought Leah liked Nick, but she actually liked Simon.

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In the book, Abby loved Simon's golden retriever, but in the movie, Biebs was a little mutt.

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This quote wasn't in the movie at all. It was so important to the interracial aspect of the story, but the movie didn't focus on it at all.