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Yes, because Sam's father had the same type of the cancer with Sam.

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'Benign' defines as harmless and 'malignant' defines as dangerous or deadly.

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Benign tumor does not affect near by tissues or spread while malignant tumor may be cancerous.

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Make someone liable to get a cancer.

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People that are predisposed to getting cancer does not definitely get cancer, but is at a higher chance of getting cancer

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When we compared Sam's APC sequence to the normal APC sequence, only one base was different.

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One possible consequence is the change of amino acids. The second possible consequence can be no change. The last possible consequence can have a STOP codon in DNA structure.

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Jane and Sam's mutation will decrease the ability of the APC protein to bind to B-catenin..

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If the APC gene is damaged, then it will not be able to bind with the B-catenin. If not bound to APC and degraded, B-catenin accumulates and can enter the nucleus and bind to T-cell factor(TCF). Binding to TCF triggers the transcription of genes that promote cell division.

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Sam's APC protein is much shorter than the normal APC protein.

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The amino acid changing into a STOP codon is the consequence of the mutation

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The DNA may overlap or