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This medication decreases the creation of thyroid hormone by preventing interactions between oxygen and iodine in the thyroid gland. This prevents the thyroid gland from overproducing thyroid hormone.

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This drug works by decreasing the production of chemicals in your body called thyroid hormones, this helps your body to produce the normal amount of thyroid hormone.

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Methimazole is distributed by the thyroid gland, metabolized by the liver, and excreted by the kidneys.

The drug begins working in 12-18 hours, and the peak effect is 1-2 hours.

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When taking this medication, the following side effects may occur: skin rash or discoloration, itching, nausea, vomiting, fatigue, headache, or joint pain.

It is important to notify your provider if you experience decreased urination, yellowing of the skin or eyes, or abnormal numbness or tingling.

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Before starting this medication, the following baseline tests will be performed:

Complete Blood Count (CBC) with differential

Thyroid Function Tests

Liver Function Tests

While taking this medication, you should not receive any live vaccines, including for influenza.  Proper hand hygiene should be performed as this medication will put you at greater risk for infection.

You will continue to be monitored for infection, bleeding, joint pain, rash, and signs of hyperthyroidism, including insomnia, fatigue, and heat sensitivity.

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A patient is prescribed methimazole (Tapazole) for the treatment of hyperthyroidism (Grave's Disease).  When discussing administration of this medication with their provider, which of the following indicates a need for further teaching?

a. I will wear sunscreen when outdoors to prevent sunburn

b. Dark-colored urine is a normal finding and is no cause for concern

c. This drug is not suitable for pregnant women

d. I will report any new sensations of tingling or burning to my provider

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Dynamed. (2022) Methimazole. Retrieved September 29, 2022,  from https://www.dynamed.com/drug-monograph/methimazole#GUID-7439015E-CB5C-45C5-ACC4-88B77EFB8521

Lexicomp. (2022). Methimazole: Monograph. Lexi-Drugs. Retrieved September 28, 2022, from https://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7267?cesid=4JR8e1BpX6d&searchUrl=/lco/action/search?q=methIMAzole&t=name&acs=true&acq=methi#