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Caffeine is a drug that stimulates the central nervous system. Caffeine is found naturally in coffee, tea, and chocolate.

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High temperature water is liquid water under pressure at temperatures between the usual boiling point, 100 °C (212 F) and the critical temperature, 374 °C (705 °F).

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liquid that is produced in making wine, beer, and liquor and that can cause changes in behavior in people who drink it:

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Isotretinoin or accutane is a medication that is used to treat severe or moderateacne. It is considered to be very strong in dosage.

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When exposed to caffeine, some side effects are; a increase in blood pressure which is not good, keeps the baby awake because it crosses the placenta, a preterm delivery will occur, frequency in urination which causes dehydration.

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A study by  "the American Journal of Obstetrics and Gynecology, it was found that women who consume 200 mg or more of caffeine daily are twice as likely to have a miscarriage as those who do not consume any caffeine.
In another study released by Epidemiology, there was no increased risk in women who drank a minimal amount of coffee daily ( between 200-350 mg per day.)"

American Pregnancy Association http://americanpregnancy.org/pregnancy-health/caffeine-intake-during-pregnancy/

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When exposed to high water temperature; It can lead to a miscarriage because of the disruption in proteins, neural tube defect which affects the brain and the spinal column, and premature delivery.

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American Pregnancy Association http://americanpregnancy.org/pregnancy-health/hot-tubs-during-pregnancy/

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When exposed to alcohol it can lead to; damage the growth of the baby's cells,  Fetal alcohol syndrome, premature growth, heart defects, miscarriage, and low birth weight.

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If Accutane is taking during pregnancy the effects are; Abnormalities of the ear, Abnormalities of the eye, Facial dysmorphia, Cleft palate, Brain problems, and Heart problems

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https://www.marchofdimes.org/pregnancy/alcohol-during-pregnancy.aspx

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https://www.drugwatch.com/accutane/
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm4902a2.htm