# data[].attributes.body
1. Cell Membrane

Proteins embedded inside

2. Enzymes

GAPase, adenylyl cyclase

4. Amino Acids

Sequence of animo acids determine protein function

5. Cellular Respiration

ATP production fuels many of the reactions

6. DNA

Has the recipe for proteins

Gene mutation is what causes disease

# data[].attributes.body
Using viruses to kill tumor cells

Additional testing of radiation and chemotherapy regiments for NF1 tumors on nerve cells

Further research into kinase protein inhibitors

# data[].attributes.body
Surgery can be considered for some tumors

Radiation and Chemotherapy are also used to treat some NF1 tumors

MEK Inhibitor

Most promising treatment right now

# data[].attributes.body
MAPK Pathway (RAS/mitogen-activated protein kinase) - Because of NF1, Neurofibromin is not active in transduction

RAS becomes hyperactive which leads to increased growth and proliferation resulting in tumors

Adenylyl Cyclase no longer as effective, microtubules are not bound to - memory/learning impaired

# data[].attributes.body
MAPK Pathway (RAS/mitogen-activated protein kinase) -

Neurofibromin (when functioning properly) helps to inhibit p21 RAS activity

Converts the active GTP-bound form to the inactive GDP-bound form

Modulates Adenylyl cyclase and binds to microtubules

# data[].attributes.body
KIT Ligand binds causing dimerization

Activates the kinase activity and leads to autophosphorylation

Proteins attach to the sites causing a change in shape and a signal to be produced

# data[].attributes.body
BASICS

# data[].attributes.body
Tumor Suppressor -

Related to Guanosine Triphosphate Activating Protein (GAP)

Acts as an on and off switch for RAS which is responsible for growth and proliferation

Boosts learning/memory -

Modulates Adenylyl cyclase which catalyzes the reaction from ATP to cAMP (a secondary messenger which which activates PKA leading to learning and memory)

Binds with microtubules

# data[].attributes.body
Genetic disorder which disrupts the production of Neurofibromin proteins

Results in tumors growing along your nerve cells

Symptoms include hearing loss, learning impairment, cardiovascular problems, loss of vision, severe pain