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Comment fonctionne le cerveau (Système nerveux humain) (Animation)

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Comment fonctionnent les interfaces cerveau-ordinateur ? (Animation)

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Le neurone et la libération des neurotransmetteurs

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La transformation du cerveau au fil de la vie

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Système nerveux humain - Moelle épinière et périphérie (Animation)

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🔍 The Human Nervous System: Your Body’s Control Center 🔍  #3danatomy #anatomy

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You don't "find your calling," you fight for it - and other lessons from people who found their passion (sometimes late in life).

Whether it was during a career aptitude test or in a heart-to-heart chat after getting laid off, chances are someone has talked to you about how to "find your calling." It's one of those phrases people toss about. But StoryCorps founder Dave Isay takes issue with it ... specifically, the verb.

"Finding your calling - it's not passive," he says. "When people have found their calling, they've made tough decisions and sacrifices in order to do the work they were meant to do."

In other words, you don't just "find" your calling - you have to fight for it. And it's worth the fight. "People who've found their calling have a fire about them," says Isay, the winner of the 2015 TED Prize. "They're the people who are dying to get up in the morning and go do their work."

Over a decade of listening to StoryCorps interviews, Isay noticed that people often share the story of how they discovered their calling - and now, he's collected dozens of great stories on the subject into a new book, Callings: The Purpose and Passion of Work. Below, he shares 7 takeaways from the hard-won fight to find the work you love.

1. Your calling is at the intersection of a Venn diagram of three things: doing something you're good at, feeling appreciated, and believing your work is making people's lives better. "When those three things line up, it's like lightning," Isay says. He doesn't suggest that a person has to be a surgeon saving lives to feel like they have a calling; think of the diner waitress who talks to customers and makes them feel loved. How do you find this overlap? "You have to shut out all the chatter of what your friends are telling you to do, what your parents are telling you to do, what society is telling you to do," Isay says, "and just go to that quiet place inside you that knows the truth."

2. Your calling often comes out of difficult experiences. What lurks in that quiet place will be a defining experience - quite possibly a painful one. Isay points to an interview in Callings with 24-year-old teacher Ayodeji Ogunniyi. "He was studying to be a doctor when his father was murdered. He realized that what he was really meant to do was be a teacher," says Isay. "He says that every time he walks into a classroom, his father is walking in with him." This theme of people turning their hardest experiences into a new path runs throughout the book. "Having an experience that really shakes you and reminds you of your mortality can be a very clarifying event in people's lives. Oftentimes, it leads to changes," he says. "We spend a lot of time working, so it can really change your priorities in terms of work life."

3. Calling often takes courage and ruffles feathers. Elsewhere in Callings, we hear about Wendell Scott, who became the first African-American NASCAR driver in 1952, and kept on driving despite threats against his life. From scientist Dorothy Warburton who dealt with extreme sexism as she conducted research to break the stigma around miscarriage. From Burnell Cotlon, who opened the first grocery store in the Lower 9th Ward after Hurricane Katrina because he wasn't about to let his old neighborhood's spirit fade. Calling, says Isay, very often starts with taking a stand against a status quo that simply isn't acceptable, and then dedicating your work to changing it: "It's work ignited by hope, love, or defiance - and stoked by purpose and persistence."

4. Other people often nudge you toward calling. Sharon Long had worked odd jobs most of her life. As Isay tells it, "Her daughter was going to college, and as the bursar was helping them with financial aid forms, she said quietly to herself, 'I wish I could've gone to college.' The bursar responded, 'It's not too late.'" Sharon enrolled in an art program, and on her advisor's suggestion, took forensic anthropology as her science. "The advisor suggested it for no other reason than he thought it was the easiest science course for the science requirement," says Isay. "But the minute she sat in that class, it was boom - this is what she was meant to do." Isay tells this story to illustrate how calling, while very personal, is also relational. "People bump you this way and that way," he says, often without realizing it. "When people find their callings, they want to honor those people who helped them get there."

5. What comes after identifying your calling is what really matters. The old 'finding your calling' phraseology makes it sound like a calling is a pot of gold at the end of the rainbow - you find it, and the story's over. But Isay stresses that your calling is an ongoing process. "Understanding what your calling is - that's very different than the blood, sweat and tears of actually doing it," he says. Pursuing a calling may require going back to school or apprenticing; it may require starting a business. Often, notes Isay, it leads a person into a line of work that's in service of others. "This book is basically a love letter to nurses, teachers, social workers - the people who don't often get celebrated for the work they do," he says.

6. Age is irrelevant. Isay found his calling when he was 21 and interviewed a man who'd been part of the Stonewall riots. "The minute I hit record, I knew that being a journalist and interviewing people was what I was going to do for the rest of my life," he says. "I feel very lucky that lightning struck when I was very young." But collecting stories for the book reminded him that a calling can be discovered at any age. The book includes an interview with someone who knew they wanted to be an NBA referee at age 15, and another who worked as an accountant for 30 years before discovering his passion for slicing lox. "Doing the work you're meant to do is one of the most satisfying, remarkable experiences that a person can have," says Isay, "so never give up."

7. Calling often doesn't come with a big paycheck. Another trend Isay sees in stories of people who find their calling: they often involve leaving a high-paying job for one that's lower-paying but more satisfying. "The message we send to young people is that you want to do as little work as you can to make as much money as you can - that's the dream," says Isay. "But the wisdom in the StoryCorps archive is that there's another, much more rewarding dream of taking risks and working very hard to live with integrity." In the end, that's the lesson he took away from writing this book. "There are no millionaires, no billionaires, no celebrities, nobody with a big Twitter following," he says. "Just stories can teach us a lot about lives fully lived."

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7 lessons about finding the work you were meant to do

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Whether it was during a career aptitude test or in a heart-to-heart chat after getting laid off, chances are someone has talked to you about how to "find your calling." It's one of those phrases people toss about. But StoryCorps founder Dave Isay takes issue with it ... specifically, the verb.

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Effet sur les neurones et les neurotransmetteurs

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Un des mécanismes synaptiques de l'addiction: Dopamine et glutamate

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Tu corazón cuando estás en una relación tóxica | Casi Creativo

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Soigner des tumeurs en utilisant le virus de la Poli

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A bold experiment to kill a vicious form of brain cancer has been granted breakthrough status by the Food and Drug Administration. Results in the earliest stage of testing have been so remarkable, the FDA wants to fast track the treatment to speed it to market.

The therapy uses the polio virus to attack glioblastoma. " 60 Minutes" has been following patients in the clinical trial for the last two years.

One of those patients was Stephanie Lipscomb. In 2011, Lipscomb was a 20-year-old nursing student with headaches. A doctor told her she had a glioblastoma tumor the size of a tennis ball and that she had months to live.

She had 98 percent of the tumor removed. Then in 2012, the doctors told her the cancer had come back.

With recurrent glioblastoma, there were no options except the one that had never been tried. Lipscomb became the first volunteer for Duke University's experiment with the polio virus.

The virus is the creation of -- or, the obsession of -- molecular biologist Matthias Gromeier.

Gromeier re-engineered the virus, removing a key genetic sequence. The virus can't survive this way, so he repaired the damage with a harmless bit of cold virus. This new modified polio virus can't cause paralysis or death because it can't reproduce in normal cells.

But it can reproduce in cancer cells, and in the process of replicating, it releases toxins that poison the cell. This process also awakens the immune system to the cancer it never noticed before.

"Why didn't the immune system react to the cancer to begin with," CBS News' Scott Pelley asked Gromeier.

"All human cancers, they develop a shield or shroud of protective measures that make them invisible to the immune system," Gromeier explained. "This is precisely what we try to reverse with our virus. So by infecting the tumor, we are actually removing this protective shield. And enabling the immune system to come in and attack."

It appears the polio starts the killing, but the immune system does most of the damage. Stephanie Lipscomb's tumor shrank for 21 months until it was gone. Three years after the infusion, something unimaginable had happened.

An MRI in August of 2014 showed no active cancer cells at all.
Scott Pelley will have more on Duke University's breakthrough trial, Sunday on "."

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Promising brain cancer trial given breakthrough status by FDA

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A bold experiment to kill a vicious form of brain cancer has been granted breakthrough status by the Food and Drug Administration. Results in the earliest stage of testing have been so remarkable, the FDA wants to fast track the treatment to speed it to market.

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Système nerveux central et système nerveux périphérique

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Regarder la vidéo "L'encéphale" envoyée par Anatomie 3D université Lyon 1 sur dailymotion.

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Le réflexe myotatique (neuroanatomie  fonctionnelle de la motricité)

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Le beau gosse d'Hollywood a été interrogé par Carly Fleischmann, une jeune femme atteinte d'autisme depuis l'enfance. Le résultat est brillant, drôle et extrêmement émouvant!

Carly Fleischmann, cette jeune américaine de 21 ans, est atteinte d'autisme depuis l'enfance et d'apraxie verbo-motrice, soit une incapacité d'effectuer des mouvements normalement. Son rêve? Devenir présentatrice d'un talkshow. Mais le hic, c'est qu'elle ne peut pas communiquer clairement et doit utiliser un ordinateur pour discuter avec le reste du monde. Et avec Channing Tatum.

Une interview brillante!

La jeune femme a dépassé son handicap pour s'adresser à la star lors d'un entretien qu'elle a diffusé sur sa chaîne Youtube. Et c'est plutôt réussi. Carly a réussi à mener une interview passionnante tout du long, en l'interrogeant sur ses conquêtes, son sex appeal et sa vie d'acteur. Une complicité s'installe petit à petit entre eux et l'interview se conclut par des hugs maladroits, drôles et touchants. De quoi lancer sa carrière!
Pour aller plus loin:

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VIDÉO: Channing Tatum, interviewé par une femme autiste

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Le beau gosse d'Hollywood a été interrogé par Carly Fleischmann, une jeune femme atteinte d'autisme depuis l'enfance. Le résultat est brillant, drôle et extrêmement émouvant! Carly Fleischmann, cette jeune américaine de 21 ans, est atteinte d'autisme depuis l'enfance et d'apraxie verbo-motrice, soit une incapacité d'effectuer des mouvements normalement. Son rêve?

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IRIS | Les opioïdes tuent de plus en plus

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Les opioïdes comprennent des narcotiques d'ordonnance comme l'OxyContin, l'hydromorphone et le fentanyl (dont certains affirment qu'il est cent fois plus puissant que la morphine). Le Dr Kendall affirme qu'en Colombie-Britannique, le nombre de surdoses attribuables aux opioïdes dépasse déjà 200 cette année. Si la tendance se maintient, on pourrait compter jusqu'à 800 cas d'ici la fin de l'année.

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Two million Americans were dependent on prescription opioids in 2014, when the most recent data was available, federal statistics show.

Overdoses linked to opioids killed more than 28,000 people nationwide two years ago, according to the Centers for Disease Control and Prevention. The deaths include those involving heroin and prescription drugs such as oxycodone and hydrocodone.

Here are four things to know about these narcotics:

What are opioids?

Opioids are drugs that reduce pain by switching off pain receptors in the brain.

They are among the most widely prescribed drugs in the United States, the CDC says, fueling an epidemic that starts at the doctor's office and spills onto the streets.

Doctors prescribe them so much, federal officials published national guidelines last month urging medical practitioners to be more judicious when recommending them to patients.

What drugs are considered opioids?

Prescription opioids include painkillers such as morphine, oxycodone and hydrocodone.

Others, such as the synthetic pain reliever fentanyl, are used for patients suffering from advanced terminal illness such as cancer.

Heroin is an illegal opioid derived from the same poppy plant as Food and Drug Administration-approved opioid pills. Use of heroin has skyrocketed nationwide due to a lower price and wider availability on the street.

Why are opioids dangerous?

While heroin is an illegal opioid and other opioid pills are prescribed, they both bind to the same group of receptors in the brain.

They produce an increased pain tolerance and in some cases, trigger a craving when the drug is absent. Individuals who use or take opioids sometimes build a tolerance, so they need higher doses for the same effect over time.

Many heroin users first became addicted to prescription pills. The heroin is a cheaper alternative, about one-tenth the price, when they can no longer get pills.

There's a ripple effect around heroin use: In addition to the risk of death and overdoses, heroin addiction comes with a whole new set of problems, such as infections of the heart lining and valves, and rheumatological diseases.

Heroin users are also more likely to suffer from HIV, hepatitis and other blood diseases because users might inject the drug with a shared needle.

The availability of the drugs on the street has not helped much, fueling an epidemic of overdoses.

How bad are opioid overdoses in the U.S.?

Every 19 minutes, someone dies from an accidental overdose, the CDC reports.

Americans represent just 5% of the world's population, but they consume 80% of the world's opioids, according to the American Society of Interventional Pain Physicians.

Most drug overdose deaths -- at least six out of 10 -- involve an opioid, federal statistics show.

"Overdose deaths involving prescription opioids have quadrupled since 1999, and so have sales of these prescription drugs," the CDC says.

While the amount of prescription opioids has grown fourfold, the amount of pain reported by Americans has not changed much, it says.

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opioids and overdoses: 4 things to know  - cnn

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Two million Americans were dependent on prescription opioids in 2014, when the most recent data was available, federal statistics show. Overdoses linked to opioids killed more than 28,000 people nationwide two years ago, according to the Centers for Disease Control and Prevention. The deaths include those involving heroin and prescription drugs such as oxycodone and hydrocodone.