# data[].attributes.attachment_link.title
What is Charcot Marie Tooth Disease? - Poll Results - StrawPoll.com

# data[].attributes.attachment_link.description
What's your opinion? Vote now: An infection of wisdom teeth resulting in a neuropathy of the sensory and motor nerves, A hereditary neuropathy of sensory and motor nerves, Exposure ...

# data[].attributes.body
Most common inherited neuromuscular disease

Affects 1 in 2500 or 2.6 million people across the world

# data[].attributes.body
Hereditary Disease

Motor and Sensory polyneuropathy of peripheral nerves (mostly distal limbs)

Late adolescence and Early adulthood

# data[].attributes.body
Mutations in the genes of the peripheral nerve axon or myelin sheath

Weak or slow impulses

# data[].attributes.body
Autosomal dominant - one copy of mutated gene received from either parent

Autosomal recessive - two copies of the mutated gene received - one from each parent

X-linked - mutation on the X chromosome

# data[].attributes.body
CMT1 - demyelinating - most common

Mutations on X chromosome

CMT2 - axonal CMT

Axonal degeneration

CMT3 - dominant autosomal - very rare

Hypomyelination and axonal hypertrophy

CMT4 - autosomal recessive inheritance - rare

Both axonal and demyelinating

CMT X1 - second most common

Affects the Schwann cells

Mutation on the X chromosome

Affects people with XY chromosomes more than people with XX chromosomes

# data[].attributes.body
Detailed family and medical history

Look for evidence of

Muscle weakness in arms, legs, hands and feet

Decreased muscle mass

Reduced tendon reflexes

Sensory loss

Foot and orthopaedic problems

Blood test to look at genetic defects

Nerve conduction studies

Electromyography

Nerve biopsy

# data[].attributes.attachment_link.authors[].name
Pass MRCPCH - London Paediatrics Trainees Committee

# data[].attributes.attachment_link.title
Charcot-Marie-Tooth (CMT) - Neurological Examination, Presentation and Parental Interview

# data[].attributes.body
Fatigue

Foot deformities

Pain

Tremors

# data[].attributes.body
Atrophy of the muscles

Difficulty walking/gait abnormalities

Loss of deep tendon reflexes

Sensory loss

# data[].attributes.body
Hereditary -> anyone in your immediate family due to gene mutation

Age: late adolescence and early adulthood

# data[].attributes.body
Prognosis:

Does not affect life expectancy

No cure

Treatment:

Physiotherapy

Occupational Therapy

Surgery:

Soft tissue surgeries

Osteotomies (removal of bone)

Joint fusion

Pain medication (NSAIDs)

# data[].attributes.body
OT/OTA

Assistive Devices

Thumb Splints

Braces (step smart)

Hightop Shoes

Wheelchairs

PT/PTA

Posture and Balance

Hydrotherapy (swimming)

Aerobic Exercises (low impact)

Strengthening

Stretching

PNF

Gait aids

# data[].attributes.attachment_link.title
Bilateral Drop Foot solution for Charcot-Marie-Tooth (CMT)

# data[].attributes.body
Affects the axon and myelin sheath of sensory and motor neurons

Hereditary

No cure but early treatment (physio) helps manage the disease

Has a average life expectancy

# data[].attributes.body
Charcot-Marie-Tooth disease. Charcot-Marie-Tooth Disease | Johns Hopkins Medicine. (2021, August 8). https://www.hopkinsmedicine.org/health/conditions-and-diseases/charcotmarietooth-disease

Charcot-Marie-Tooth disease. Physiopedia. (n.d.). https://www.physio-pedia.com/Charcot-Marie-Tooth_disease

Corrado, B., Ciardi, G., & Bargigli, C. (2016). Rehabilitation Management of the Charcot-Marie-Tooth Syndrome: A Systematic Review of the Literature. Medicine, 95(17), e3278. https://doi.org/10.1097/MD.0000000000003278 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998680/

U.S. Department of Health and Human Services. (n.d.). Charcot-Marie-Tooth disease. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/charcot-marie-tooth-disease#:~:text=CMT%20affects%20both%20sensory%20and,legs%2C%20hands%2C%20or%20feet

U.S. National Library of Medicine. (n.d.). Charcot-Marie-Tooth disease: Medlineplus Genetics. MedlinePlus. https://medlineplus.gov/genetics/condition/charcot-marie-tooth-disease/#inheritance