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Victor Frankenstein becomes consumed by his experiments at the University of Ingolstadt, leading to isolation from friends and family. Driven by ambition, he successfully creates a living being, but the moral consequences of his actions begin to trouble him deeply. This chapter marks a pivotal moment as Victor grapples with the ethical implications of playing with the forces of life.

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Victor Frankenstein is tormented by guilt and fear after creating the creature. He falls into a feverish state and becomes seriously ill. During his illness, he's visited by his friend Clerval, who takes care of him. Victor slowly recovers but remains haunted by the consequences of his actions. The chapter also reveals that the creature that Victor brought to life, is responsible for the murder of Victor's younger brother, William. This adds a layer of horror and tragedy to Victor's emotional and physical struggles, deepening his sense of remorse and the profound impact of his scientific experimentation. The murder of William becomes a crucial element in the unfolding narrative, foreshadowing the devastating consequences of Victor's creation.

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Victor learns that Justine has been accused of the murder. After the discovery of the body, a servant had found in Justine’s pocket a picture of Caroline that Frankenstein last seen in William’s possession. Victor proclaims Justine’s innocence, but the evidence against her seems irrefutable, and Victor refuses to explain himself for fear that he will be labeled insane. Justine's story highlights the themes of injustice and the harsh consequences resulting from Victor's creation, emphasizing the moral complexities and ethical dilemmas woven into the narrative.

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After Justine’s execution, Victor becomes depressed. He thinks of suicide but stops himself by thinking of Elizabeth and his father. Alphonse, hoping to cheer up his son, takes his kids on an excursion to the family home at Belrive. From there, Victor wanders alone to the valley of Chamounix. The beautiful scenery cheers him a little bit, but his respite from grief is short-lived.