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Group 8 sec 3
Puja Biswas -19146091
Tahmeed Ahmed -19146046
Billal Hossain Tusher -19146030
Submitted to -
Dr. Raushanara Akter ,
Associate Professor
Department of pharmacy,
Brac University

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Examples -

•Remdesivir
•Morphine
•Propranolol
•Buprenorphine
•Diazepam

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The first-pass effect happens when a drug is taken orally, enters the liver, and undergoes substantial biotransformation to the point where its bioavailability is substantially reduced, resulting in subtherapeutic activity

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How first pass effect reduce bioavailability of oral drugs?

When drug enters the liver-
• it metabolises drugs to such an extent that only a small amount of active drug emerges from the liver to the systemic circulation
• thus greatly reduces the bioavailability of drugs .

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A simple math to understand the impact of first pass effect on bioavailability of oral drugs