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Proteus Syndrome  is a genetic disorder in which there is overgrowth in bones, skin, and other tissues. The organs an tissues affected by the disease grow out of proportions to the rest of the body.

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Proteus Syndrome is cause by a mutation in the AKT1 gene. Unlike other genetic disorders Proteus Syndrome is not inherited but it occur in early development, and is unknown in how is occurs.

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-Disproportionate overgrowth of the hands, feet, bones, and organs.
-Skeletal malformations, tumors, scoliosis, irregular blood vessels, lung disease, skin lesions or discoloration, tumors etc.

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Proteus Syndrome can be hard to diagnose do to the large variety of symptoms. There are no precise genetic test to detect Proteus Syndrome due to the rarity of the disease. You can only be diagnosed by a physician. After careful observations and imaging studies.

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- Abnormal blood clotting which includes deep vein thrombosis and pulmonary embolism.
- Tumors, obstructed vision, tumors, lung disease, and central nervous system failure.

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National Human Genome Research Institute

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Proteus Syndrome Treatment - Leslie Biesecker with patient Jerry DeVries

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Rebecca Lynn Browder - Living With Proteus Syndrome

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Proteus Syndrome has no cure but there are treatments that may ruduce the risk of complications. The treatments will vary from patient to patient, depending on their symptoms. Treatments like physical therapy to improve mobility, ruduce pain, prevent further injuries, etc. As we as psychotherapy to help mange many different aspects of the disease.

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https://ghr.nlm.nih.gov/condition/proteus-syndrome
https://ghr.nlm.nih.gov/condition/proteus-syndrome#inheritance
http://www.livingnaturally.com/ns/DisplayMonograph.asp?
StoreID=9es5fkaq17s92nd700akhlbd345caab3&DocID=condition-proteussyndrome
http://www.scielo.br/scielo.php?pid=S0104-42302013000400007&script=sci_arttext&tlng=en

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The life expectancy of Proteus Syndrome ranges from 9 months to 29 years depending on the severity of the abnormalities.