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Any chemical reaction must create a new substance. Examples: Ca (calcium) and Cl₂ (2 chlorine atoms) form a new substance called calcium chloride, N (nitrogen) and H₃ (3 hydrogen atoms) form to create the compound ammonia.

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When vinegar and baking soda are mixed at room temperature, the temperature of the solution goes down. This shows a chemical reaction occurred, because temperature change is one of the FACTSS that indicate a chemical reaction happened.

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Endothermic Reaction - Baking Soda and Vinegar

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When the colorless liquid potassium chloride (KCl) is placed over a flame, the flame color changes to purple. This demonstrates a chemical reaction because it changed into a completely different color, a sign of a chemical change. In this reaction, potassium and chlorine are the reactants and potassium chloride is the product.

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Qualitative Flame Test - KCl Potassium Chloride

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9% KCl Solution Dissolved in Distilled Water

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H (hydrogen) + C (carbon) + N (Nitrogen)= HCN (hydrogen cyanide, or prussic acid)
Hydrogen, carbon, and nitrogen bond together to create this toxic liquid that smells like bitter almonds. This is an indicator that a reaction has taken place because separately, all of these elements are odorless, and together they have a distinctly different smell than before. In this reaction, hydrogen, carbon, and nitrogen are the reactants and hydrogen cyanide is the product.

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Alka seltzer tablets are sodium bicarbonate and citric acid in powdered form, when they haven't mixed yet. When placed in water, they fizz, or create carbon dioxide gas, because they're reacting to each other. Since gas was created, this tells us that a chemical reaction is occurring.

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Na (sodium) + Cl (chlorine) = NaCl (sodium chloride, or table salt)
In this chemical reaction, chlorine in gas form and sodium in solid form bond together to form a solid which is known as sodium chloride. The reason this shows a chemical change is because the gas and solid came together to form a solid, one of the FACTSS that show a chemical reaction. In this experiment,  chlorine and sodium are the reactants, or what we have before the experiment, and sodium chloride is the product of the reaction.