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Rejoyn is a pioneering FDA-authorized prescription digital therapeutic (PDT) developed to support the treatment of Major Depressive Disorder (MDD) in adults aged 22 and older. Created through a collaboration between Otsuka America Pharmaceutical, Inc. and Click Therapeutics, Rejoyn offers a six-week, app-based intervention that combines cognitive-emotional training (CET) exercises with cognitive behavioral therapy (CBT)-based video lessons (Otsuka America Pharmaceutical, Inc., n.d.).

The app's therapeutic foundation is based on the Emotional Faces Memory Task (EFMT), which has shown efficacy in reducing depressive symptoms in clinical trials (Iacoviello et al., 2018). Designed to be used alongside antidepressant medication, the app delivers daily, interactive exercises aimed at enhancing cognitive control over emotional processing. Clinical trials have demonstrated its effectiveness in improving depressive symptoms, offering a non-pharmacologic, structured, and user-friendly treatment option without reported side effects from the app itself.

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Meet Rejoyn: the prescription app that helps treat depression symptoms

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With Rejoyn, patients can access treatment on their smartphones, on their own time. New exercises are unlocked at midnight the day they become available and expire at the end of each week.

Completing the CET brain exercises in Rejoyn takes about 20 to 30 minutes each, and the CBT-based video lessons take about 5 minutes each, so patients can fit treatment into their own schedules.

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Rejoyn: First and only prescription app for MDD symptoms

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Rejoyn is the first and only prescription app for the treatment of MDD symptoms. It is a 6-week adjunctive treatment authorized by the FDA.

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FDA-Authorized and Clinically Reviewed: Rejoyn is the first prescription digital therapeutic approved by the FDA for adjunctive treatment of Major Depressive Disorder (MDD), lending it legitimacy and clinical oversight (Otsuka America Pharmaceutical, Inc., n.d.).

Non-Pharmacologic and Side-Effect-Free: As an app-based treatment, Rejoyn offers therapeutic support without adding pharmacologic side effects, which is particularly beneficial for patients sensitive to medications or experiencing adverse drug reactions (Iacoviello et al., 2018).

Enhances Cognitive Control: Rejoyn uses cognitive-emotional training to improve the brain's regulation of emotional responses, a process shown to reduce depressive symptoms in clinical trials (Iacoviello et al., 2018).

Flexible and Private: Patients can engage in the six-week therapy from the comfort of their home, at their own pace and schedule, removing barriers such as transportation or stigma.

Supports Engagement Between Visits: Rejoyn empowers patients with daily therapeutic activities, filling gaps between psychiatric or therapy appointments and reinforcing healthy mental health habits.

Structured and Interactive Format: The combination of interactive exercises and CBT-based video content keeps users actively engaged in their own care, which may improve treatment adherence and outcomes.

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Limited Effectiveness: While Rejoyn showed some benefit in reducing depression symptoms, the improvement was small compared to a control group using a sham app. The difference did not meet the threshold typically considered clinically meaningful (American Academy of Family Physicians [AAFP], 2024).

Out-of-Pocket Cost: Users must pay around $200 for the six-week program, though a discount code can reduce the cost to $50 if insurance doesn’t apply (Otsuka America Pharmaceutical, Inc., n.d.).

Add-On Therapy: Rejoyn is meant to be used with antidepressants, not by itself. This limits its use for people who want a non-drug approach (Otsuka America Pharmaceutical, Inc., n.d.).

Daily Use Commitment: The app requires daily use for 20–30 minutes over six weeks, which may be difficult for patients with low motivation or fatigue—common in depression (Iacoviello et al., 2018).

Technology Barriers: Patients need a smartphone and some comfort using apps. This can be a barrier for older adults or people with limited access to technology.

Not Much Long-Term Data: Most studies on Rejoyn have been short-term. We still don’t know how well it works over longer periods or with different types of patients (AAFP, 2024).

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As a PMHNP student, I believe Rejoyn represents a promising and innovative step toward expanding mental health care beyond traditional clinical settings. Its integration of CBT-based content and cognitive-emotional training into a digital format allows patients to actively engage in their treatment, even between provider visits. This aligns with holistic, patient-centered care, which I strongly value.

The app’s accessibility and non-pharmacologic nature make it a useful adjunct for patients who might be hesitant to increase or change medications. While its modest effect size and limited coverage are important considerations, I see Rejoyn as a valuable option for those needing flexible, supplemental support. As I grow into the PMHNP role, I see myself recommending digital tools like this as part of a multimodal treatment plan, especially for patients struggling with motivation or limited access to traditional care.

I value how Rejoyn blends evidence-based strategies like CBT and cognitive-emotional training into a user-friendly format. It provides support without adding medication side effects and encourages consistency and structure, which are important components in depression recovery. I believe tools like Rejoyn can complement the care I provide by extending therapeutic support beyond the clinic and into patients' everyday lives.

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Achiever – I’m someone who thrives on productivity and getting things done. I take pride in setting goals and following through, which helps keep projects like this moving forward. When implementing tools like Rejoyn, I’ll be the one making sure deadlines are met and details aren’t missed.

Empathy – I genuinely care about how others feel. In this project, I’ll naturally think about how patients might respond emotionally to using something new, especially those struggling with depression. This helps ensure we stay compassionate and patient-centered in our approach.

Connectedness – I see how everything is part of a bigger picture. I believe that mental health tools like Rejoyn aren’t just clinical add-ons—they’re a way to connect people with hope, healing, and support beyond traditional settings.

Developer – I love seeing people grow. Whether it’s helping team members learn how to use the app or encouraging patients through small wins, I get excited about progress and am patient with the learning process.

Includer – I make sure no one is left out. I’m especially sensitive to populations that often don’t have access to new technologies, and I’ll advocate for making Rejoyn as inclusive and accessible as possible.

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Carter – Communication: Carter knows how to explain things clearly and in a way that makes people listen. With him on our team, we can present Rejoyn to staff and patients in a way that makes them feel curious and confident about using it.

Angelica – Analytical: Angelica brings sharp critical thinking to the table. She’ll help us dig into the data and outcomes, making sure our decisions are grounded in solid evidence.

Louis – Learner: Louis is excited to keep learning and improving. He’ll make sure we stay up to date on updates and training for Rejoyn, and he’ll help others feel comfortable using it too.

Randall – Responsibility: Randall can always be counted on. He’ll help make sure our project stays ethical and compliant, and that we follow through on what we say we’ll do.

Sheila – Strategic: Sheila is great at seeing the path ahead. She’ll help us create a plan to roll out Rejoyn in a way that’s practical, efficient, and thoughtful.