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- Gayathri

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  RNA Polymerases are enzymes that transcribe DNA into RNA. Using a DNA template, RNA polymerase builds a new RNA molecule through base pairing. RNA polymerase always builds a new RNA strand in the 5' to 3' direction i.e. it can add only RNA nucleotides (A, U, C or G) to the 3' end of the strand.

# data[].attributes.subject
  RNA Polymerases are enzymes that transcribe DNA into RNA. Using a DNA template, RNA polymerase builds a new RNA molecule through base pairing. RNA polymerase always builds a new RNA strand in the 5' to 3' direction i.e. it can add only RNA nucleotides (A, U, C or G) to the 3' end of the strand.

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Transcription uses one of the two strands of DNA as a template. It is called as a Template strand.

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Transcription uses one of the two strands of DNA as a template. It is called as a Template strand.

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In humans the main RNA polymerase does not attach instantly to promoters instead require transcription factors bind to promoter first which help the RNA polymerase to get hold on the DNA.

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In humans the main RNA polymerase does not attach instantly to promoters instead require transcription factors bind to promoter first which help the RNA polymerase to get hold on the DNA.

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Many eukaryotic promoters possess a sequence - TATA Box. It is recognized as one of the transcription factors. Transcription is also regulated by upstream control elements that lie 5' to the TATA box.

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Many eukaryotic promoters possess a sequence - TATA Box. It is recognized as one of the transcription factors. Transcription is also regulated by upstream control elements that lie 5' to the TATA box.

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• As the elongation complex containing the core RNA polymerase progresses along the DNA molecule, DNA unwinding must occur in order to provide access for the appropriate base pairing to the nucleotides of the template strand.
• The extent of this transcription bubble (i.e., DNA unwinding) is constant throughout and is about 20 base pairs per polymerase molecule.

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RNA polymerase has associated with it an "unwindase" activity that opens the DNA helix. Topo isomerase both precedes and follows the progressing RNAP to prevent the formation of super helical complexes. Base pairing rule is followed during the incorporation of ribonucleotides.