# data[].attributes.body
Osteogenesis imperfecta is a genetic disorder that affects the bones. The bones do not produce good collagen to make them strong so the bones are very fragile and will break easily. Symptoms of this disorder depends on the type of osteogenesis imperfecta a person inherits. The focus of this article is Type III and the symptoms include fractures of bone in the womb, loose joints, poor muscle development, respiratory problems, and very brittle bones.

# data[].attributes.body
The disorder is a rare disorder that is caused by a chromosomal mutation in several genes that code for normal collagen.  Ninety percent of the cases include mutations in COL1A, COL1A2, CRTAP, and P3H1 genes.  Normal genes produce normal collagen which provides strength and support in bone cells. These gene mutations produce abnormal collagen.

# data[].attributes.headline
How is Osteogenesis Imperfecta diagnosed?

# data[].attributes.subject
How is Osteogenesis Imperfecta diagnosed?

# data[].attributes.body
This disorder can be diagnosed to a fetus while it is in the womb. A test called Chorionic Villus Sampling can test fetal cells for normal collagen. There can also be genetic testing for adults with mild forms of OI.

# data[].attributes.body
Treatment of OI depends on how severe the disorder is.  There are different types of OI, ranging from Type 1 to Type 8.  Type 1 is the mildest and Type 8 is the most severe.  Medicines can be used to increase bone mass. There is usually a lot of occupational therapy to stabilize bones and joints.  Surgery may also be necessary to insert rods to stabilize bones.
There are some medications available, such as Aredia, and Reclast. In the future, scientists will be looking into cell based therapy, bone marrow and stem cell transplants, and allele-specific silencing gene therapy.

# data[].attributes.body
Here are 3 links to more research or current articles:
More information:
https://rarediseases.info.nih.gov/diseases/1017/osteogenesis-imperfecta
OI Foundation:
http://www.oif.org/site/PageServer?pagename=RS_Update
Recent developments:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566283/